THOMAS L. PETTY

ASPEN LUNG CONFERENCE

48th Annual Meeting

"Pathobiology of COPD"

June 13-17, 2005

Content

• Monday evening
• Tuesday morning
• Tuesday afternoon
• Wednesday morning
• Thursday morning
• Thursday afternoon
• Friday morning
• Tuesday Posters
• Thursday Posters

Monday, June 13, 2005 -- Evening

5:00-7:00 PM

Evening Registration -- Wine and Cheese Reception Given Institute

Tuesday, June 14, 2005 -- Morning

8:00-8:20AM

Introduction/Overview
Norbert F. Voelkel, M.D., Chair
Thomas L. Petty, M.D., Co-Chair
R. William Vandivier, M.D., Co-Chair

Chair - Stephen Rennard, M.D.

8:30-9:15 AM

ROGER S. MITCHELL LECTURE
"COPD PHENOTYPES"
Bartolome R. Celli, M.D.
Chief, Pulmonary and Critical Care Division
Caritas St. Elizabeth's Medical Center
Boston, Massachusetts

9:15-9:30 AM   Discussion

9:30-9:45 AM

USE OF PROTEOMIC PATTERNS OF SERUM BIOMARKERS IN PATIENTS WITH COPD. CORRELATION WITH CLINICAL PARAMETERS. V. Pinto-Plata*¹, J. Toso², K. Lee², J. Bilello², H. Mullerova², M. De Souza², R. Vessey², B. Celli¹, ¹Caritas St. Elizabeth's Medical Center, Tufts University, Boston, MA; ²Discovery Medicine and Worldwide Epidemiology, GlaxoSmithKline R&D.

9:45-10:00 AM

COMPREHENSIVE ANALYSIS OF GENE EXPRESSION ON GOLD-2 VERSUS GOLD-0 SMOKERS REVEALS NOVEL GENES IMPORTANT IN THE PATHOGENESIS OF COPD. W. Ning*, C-J. Li*, N. Kaminski*, C.A. Feghali-Bostwick*, S.M. Alber, Y.P. Di, S. Otterbein*, R. Song*, S. Hayashi•, Z. Zhou*, S.C. Watkins, J.M. Pilewski*, D.G. Peters*, J.C. Hogg*, A.M.K. Choi*, *University of Pittsburgh, Nanjing Normal University, Nanjing, CHINA, University of British Columbia, Vancouver, British Columbia, CANADA.

10:00-10:30 AM   Coffee Break

Chair - Mark Geraci, M.D.

10:30-11:15 AM

GILES F. FILLEY LECTURE
"COMPLEX SYSTEMS"
Ary L. Goldberger, M.D.
Harvard Medical School
Beth Israel Deaconess Medical Center
Boston, Massachusetts

11:15-11:30 AM   Discussion

11:30-11:45 AM

DIVERSE EXPRESSION OF ANTIOXIDANTS AND INFLAMMATORY CHEMOKINES IN TERMINAL BRONCHIOLAR EPITHELIUM IN COPD.   T. Betsuyaku*, S. Fuke, Y. Nasuhara, T. Morikawa, S. Kondo, M. Nishimura, First Department of Medicine and Second Department of Surgery, Hokkaido University School of Medicine, Sapporo, JAPAN.

11:45-12:00

MICROARRAY DATA-BASED PRIORITIZATION OF COPD SUSCEPTIBILITY GENES.  S. Bhattacharya, D.L. DeMeo, C.P. Hersh, E.K. Silverman, T.J. Mariani*, Pulmonary Medicine Brigham and Women's Hospital, and The Lung Biology Center, Harvard Medical School, Boston, MA.

12:00-1:30 PM   Lunch

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Tuesday, June 14, 2005 -- Afternoon

Chair - York Miller, M.D.

1:30-2:15 PM

STATE OF THE ART
"Genetics of COPD"
Professor William O.C. Cookson, M.D., Ph.D.
University of Oxford, UK

2:15-2:30 PM   Discussion

2:30-2:45 PM

RELATIONSHIP OF MATRIX METALLOPROTEINASE (MMP) mRNA EXPRESSION AND GENETIC POLYMORPHISMS TO EMPHYSEMA.  R.T. Abboud*, A.M. Wallace, J.C. English, N.L. Müller, H. Coxson, P.D. Paré, A.J. Sandford, University of British Columbia, Division of Respiratory Medicine, the James Hogg iCapture Centre, and Departments of Pathology and Radiology, Vancouver, BC, CANADA.

2:45-3:00 PM

INTERLEUKIN-6 GENE POLYMORPHISM CONFERS SUSCEPTIBILITY TO PULMONARY HYPERTENSION IN COPD. S. Eddahibi*, A. Chaouat, L. Tu*, C. Chouaid*, E. Weitzenblum, B. Housset*, B. Maitre*, S. Adnot*, *INSERM U92 and Department de Physiologie, Hopital H. Mondor, Creteil; Service de Pneumologie, Hopital de Hautepierre, Strasbourg; *Service de Pneumologie, Hopital Intercommunal de Creteil, Creteil, FRANCE.

3:00-3:30 PM  Break

3:30-3:45 PM

GENETIC DETERMINANTS OF FUNCTIONAL IMPAIRMENT IN THE NATIONAL EMPHYSEMA TREATMENT TRIAL.  C.P. Hersh*, D.L. DeMeo, R. Lazarus, J.C. Celedon, B.A. Raby, J. Benditt, F. Martinez, P. Scanlon, F. Sciurba, J. Utz, J.J.Reilly, E.K. Silverman, Brigham and Women's Hospital, Boston, MA; University of Washington, Seattle; University of Michigan, Ann Arbor; Mayo Clinic, Rochester, MN; University of Pittsburgh, PA.

3:45-4:00 PM

GENETIC CONTROL OF TGF-β1-INDUCED EMPHYSEMA AND FIBROSIS IN THE MURINE LUNG.  C.G. Lee*, S. Cho, R.J. Homer, J.A. Elias, Section of Pulmonary and Critical Care Medicine and Department of Pathology, Yale University School of Medicine, New Haven, CT.

4:00-4:15 PM  Break

4:15-4:30 PM

ACTIVATION OF THE MMP-1 PROMOTER BY CIGARETTE SMOKE IN HUMAN SMALL AIRWAY EPITHELIAL CELLS REQUIRES ERK MAP KINASE SIGNALING: DIFFERENTIAL RESPONSE OF THE 1G AND 2G PROMOTER SEQUENCES.  B. Mercer*, C. Brinckerhoff, J. D'Armiento, Institute of Human Nutrition, Department of Medicine, Columbia University, New York, NY, Department of Biochemistry, Dartmouth Medical School, Lebanon, NH.

4:30-4:45 PM

MT1-MMP IN COPD AND MICE EXPOSED TO CIGARETTE SMOKE.
J.J. Atkinson*, G.L. Griffin, K. Holmbeck, H. Birkedal-Hansen, G.A. Patterson, R.M. Senior, Washington University, St. Louis, MO; Skeletal Diseases Branch NIH/NIDCR, Bethesda, MD

5:00 PM   POSTER VIEWING --- SOCIAL HOUR

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Wednesday, June 15, 2005 -- Morning

Chair - Barry Make, M.D.

8:00-8:45 PM

THOMAS A. NEFF LECTURE
"COPD A SYSTEMIC DISEASE"
Alvar G.N. Agusti, M.D.
Servei de Pneumologia and Anatomic Patologic
Hospital Universitari Son dureta
Palma Mallorca, SPAIN

8:45-9:00 AM   Discussion

9:00-9:15 AM

EXACERBATION OF COPD: PAN-AIRWAY AND SYSTEMIC INFLAMMATORY INDICES.  J.R. Hurst*, W.R. Perera, T.M.A. Wilkinson, G.C. Donaldson, J.A. Wedzicha, Academic Unit of Respiratory Medicine, St. Bartholomew's and The Royal London School of Medicine, London, UNITED KINGDOM.

9:15-9:30 AM

HAEMOPHILUS INFLUENZAE ISOLATES ASSOCIATED WITH COPD EXACERBATION INDUCE MORE INFLAMMATION THAN COLONIZERS.  D.C. Look*, C.L. Chin, L.J. Manzel, E.E. Lehman, A.L. Humlicek, L. Shi, T.D. Starner, G.M. Denning, T.F. Murphy, S. Sethi, Departments of Internal Medicine and Pediatrics, University of Iowa Carver College of Medicine, and Veterans' Administration Medical Center, Iowa City, Iowa, and Department of Medicine, University at Buffalo, State University of New York, and Department of Veterans Affairs Western New York Healthcare System, Buffalo, NY.

9:30-10:00 AM   Coffee Break

Co-Chairs - Mark Nicolls, M.D. and

  R. William Vandivier, M.D.

10:00-10:45 AM

STATE OF THE ART
"Autoimmune Mechanisms" Lawrence Steinman, M.D.
Stanford University Medical Center

10:45-11:00 AM  Discussion

11:00-11:15 AM

ACTIVATION OF OLIGOCLONAL CD4+ T CELLS IN THE LUNGS OF PATIENTS WITH SEVERE EMPHYSEMA.  A.K. Sullivan*, P.L. Simonian, M.T. Falta, G.P. Cosgrove, K.K. Brown, B.L. Kotzin, N.F. Voelkel, A.P. Fontenot, University of Colorado Denver, Denver, CO and National Jewish Medical and Research Center, Denver, CO.

11:15-11:30 AM

MECHANISMS OF AUTOIMMUNE EMPHYSEMA.
L. Taraseviciene-Stewart*, M.R. Nicolls, N. Burns, D. Kraskauskas, R. Scerbavicius, K.H. Choe, A. Sullivan, #R.M. Tuder, N.F. Voelkel, Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver, CO and #Johns Hopkins School of Medicine, Division of Cardiopulmonary Pathology, Baltimore, MD.

11:30-11:45 AM

PERIPHERAL CD4 T-CELLS IN COPD PATIENTS ARE ACTIVATED AND HAVE ALTERED EFFECTOR PHENOTYPES, AND THESE ABNORMALITIES CORRELATE WITH DISEASE EXTENT.  A. Gadgil*, X. Zhu, F. Sciurba, S. Duncan, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.

11:45 AM  Instructions for Picnic

12:00 Noon  Picnic at East Maroon Bells Portal

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Thursday, June 16, 2005 -- Morning

Co-Chairs - James Fisher, M.D. and

  Karen Fagan, M.D.

8:00-8:45 AM

STATE OF THE ART
"Bronchiolitis"
James C. Hogg, M.D., Ph.D.
St. Paul's Hospital/University of British Columbia

8:45-9:00 AM  Discussion

9:00-9:15 AM

CIGARETTE SMOKE CAUSES SMALL AIRWAY REMODELING BY DIRECT GROWTH FACTOR INDUCTION AND RELEASE.  A. Churg*, R.D. Wang, J.L. Wright, Department of Pathology, University of British Columbia, Vancouver, BC, Canada.

9:15-9:30 AM

REGULATION OF AIRWAY MUCIN SECRETION BY MARCKS PROTEIN INVOLVES THE CHAPERONES HEAT SHOCK PROTEIN 70 AND CYSTEINE STRING PROTEIN.  J. Park, S. Fang, K.B. Adler*, Department of Molecular and Biomedical Science, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.

9:30-10:00 AM   Coffee Break

10:00-10:45 AM

STATE OF THE ART
"The COPD Asthma Spectrum"
Jack A. Elias, M.D.
Yale University School of Medicine

10:45-11:00 AM   Discussion

Chair - Robert Senior, M.D.

11:00-11:45 AM

PARKER B. FRANCIS LECTURESHIP
"ANTITRYPSIN DEFICIENCY, SERPINOPATHIES AND COPD"
Professor David A. Lomas, M.D., Ph.D.
Respiratory Medicine Unit
University of Cambridge
Cambridge Institute for Medical Research
Cambridge, United Kingdom

11:45-12:00   Discussion

12:00-12:15 PM

THE SERPINE2 GENE IS ASSOCIATED WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. D. DeMeo*, T. Mariani, C. Lange, S. Lake, A. Litonjua, J. Celedon, J. Reill, H.A. Chapman, D. Sparrow, A. Spira, J. Beane, V. Pinto-Plata, F.E. Speizer, S. Shapiro, S.T. Weiss, E.K. Silverman, 1)Brigham & Women's Hospital, Channing Lab, Boston, MA; 2) Brigham & Women's Hospital, Division of Pulmonary and Critical Care, Boston, MA; 3) Beth Israel Deaconess Medical Center, Division of Pulmonary and Critical Care, Boston, MA; 4) Harvard School of Public Health, Boston, MA; 5) University of California at San Francisco, Division of Pulmonary and Critical Care, San Francisco, CA; 6) Veterans Affairs Medical Center, Boston, MA; 7) Pulmonary Center, Boston University Medical Center, Boston, MA; 8) Bioinformatics Program, College of Engineering, Boston University Medical Center, Boston, MA; 9) St. Elizabeth's Hospital, Boston, MA.

12:15-12:30 PM

INCREASED COLLAGEN IN M ANTITRYPSIN EMPHYSEMATOUS LUNGS: THE ROLE OF CONFORMATIONAL TRANSITIONS OF ANTITRYPSIN.  C. Atkinson, H. Parfrey, M. Southwood, R. Pitman, M. Ueda, S. Stewart, M. Goddard, R. Mahadeva*, Department of Medicine, University of Cambridge, and Department of Histopathology, Papworth NHS Trust, Cambridge, UNITED KINGDOM.

12:30-1:30 PM   Lunch

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Thursday, June 16, 2005 -- Afternoon

Chair - R. William Vandivier, M.D.

1:30-2:15 PM

STATE OF THE ART
"Molecular and Cellular Mechanisms of Alveolar Destruction in Emphysema"
Rubin M. Tuder, M.D.
Johns Hopkins University

2:15-2:30 PM   Discussion

2:30-2:45 PM

CERAMIDE CAUSES PULMONARY CELL APOPTOSIS AND EMPHYSEMA. A ROLE FOR SPHINGOLIPID HOMEOSTASIS IN THE MAINTENANCE OF ALVEOLAR CELLS.  I. Petrache*, V. Natarajan, L. Zhen, T.R. Medler, A. Richter, W.C. Hubbard, E.V. Berdyshev, R.M. Tuder, Division of Pulmonary and Critical Care Medicine, Division of Allergy and Immunology, Department of Medicine, and Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

2:45-3:00 PM

EPITHELIAL CELL PPARγ IS AN ENDOGENOUS REGULATOR OF NORMAL LUNG MATURATION AND MAINTENANCE.  D.M. Simon, M.C. Arikan, S. Srisuma, T. Andalcio, F.J. Gonzalez, S.D. Shapiro, T.J. Mariani*, Brigham and Women's Hospital, Children's Hospital, Boston, MA and †National Cancer Institute, Bethesda, MD.

3:00-3:30 PM  Break

Chair - Rubin Tuder, M.D.

3:30-3:45 PM

STATE OF THE ART
"Phagocytosis, Clearance in COPD"
Peter M. Henson, Ph.D.
National Jewish Medical and Research Center

3:45-4:00 PM  Discussion

4:00-4:15 PM

STATINS ENHANCE CLEARANCE OF APOPTOTIC CELLS THROUGH MODULATION OF RHO-GTPases.
K. Morimoto*, W.J. Janssen, M.B. Fessler, Y.Q. Xiao, K.A. McPhillips, V.M. Borges, J.A. Kench, P.M. Henson, R.W. Vandivier, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver and Department of Immunology, National Jewish Medical and Research Center, Denver, CO.

4:15-4:30 PM

A ROLE FOR PROSTACYCLIN SYNTHASE IN SMOKING RELATED LUNG DISEASE. S. Patrick Nana-Sinkam*, J.D. Lee, L. Taraseviciene-Stewart, S. Sakao, S. Sotto-Santiago, R.L. Keith, M.W. Geraci, N.F. Voelkel, Division of Pulmonary Sciences and Critical Care Medicine and COPD Center, University of Colorado Denver, Denver, CO and College of Medicine, Gyeongsang National University, Chinju, SOUTH KOREA.

4:30-4:45 PM

IFN-γ-DEPENDENT DNA INJURY AND OR APOPTOSIS ARE CRITICAL IN CIGARETTE SMOKE-INDUCED MURINE EMPHYSEMA.
M.J. Kang*, C.G. Lee, S.J. Cho, R.H. Homer, J.A. Elias, Section of Pulmonary and Critical Care Medicine and Department of Pathology, Yale University School of Medicine, New Haven, CT.

5:00-7:00 PM  POSTER VIEWING

    WINE AND CHEESE RECEPTION

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Friday, June 17, 2005 -- Morning

Co-Chairs - Reuben Cherniack, M.D. and

   E. Rand Sutherland, M.D., MPH

7:30-8:15 AM

STATE OF THE ART
"Lung Imaging"
Eric A. Hoffman, Ph.D.
University of Iowa College of Medicine

8:15-8:30 AM   Discussion

8:30-8:45 AM

AIRWAY AND PARENCHYMAL DISEASE IN COPD ARE DISTINCT PHENOTYPES.  B. Patel, B. Make*, H.O. Coxson, N.L. Muller, S. Pillai, W. Anderson, E. Silverman, D. Lomas for the GSK COPD International Genetics Network.

8:45-9:00 AM

RELATIONSHIP BETWEEN PATHOLOGIC CHARACTERISTICS OF PERIPHERAL AIRWAYS AND OUTCOME FOLLOWING LUNG VOLUME REDUCTION SURGERY IN SEVERE COPD.  F.C. Sciurba*¹, F.J. Martinez², R.M. Rogers¹, B.J. Make³, G.J. Criner⁴, R.M. Cherniack⁴, S.A. Patel, F. Chu⁵, H.O. Coxson⁵, A. Sharafkhaneh⁶, M. Elliot⁵, J.D. Luketich¹, J.C. Hogg⁵, University's of Pittsburgh¹, Michigan², Colorado³, British Columbia⁵, Temple University⁴, and Baylor College of Medicine⁶.

9:00-9:30 AM   Coffee Break

Chair - Thomas Petty, M.D.

9:30-10:15 AM

STATE OF THE ART
"COPD - Inflammation and Lung Cancer"
Jerome S. Brody, M.D.
Boston University School of Medicine

10:15-10:30 AM  Discussion

10:30-10:45 AM

CIRCULATING CD34+ CELLS ARE DECREASED IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD).  P. Palange¹, U. Testa², A. Huertas¹, L. Calabro², R. Antonucci¹, E. Petrucci², G. Morici^{3, 4}, M.A. Vignola^{4, 5}, P. Serra¹, G. Bonsignore⁴, V. Bellia⁵, M.R. Bonsignore*^{4, 5}, ¹Dipartimento di Medicina Clinica, University "La Sapienza", Rome, ITALY; ²Istituto Superiore di Sanita', Rome, ITALY; ³Department of Experimental Medicine, University of Palermo, ITALY; ⁴IBIM-CNR, Palermo, ITALY; and ⁵Institute of Medicine and Pneumology, University of Palermo, ITALY.

10:45-11:30 AM

CONFERENCE SUMMARY
Professor William MacNee, M.D.
Respiratory Medicine
University of Edinburgh Medical School
Edinburgh, Scotland
UNITED KINGDOM

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POSTER VIEWING -- SOCIAL HOUR

Tuesday, June 14, 2005, 5:00 PM

POSTERS

DECREASED C/EBP TRANSCRIPTION FACTOR ACTIVITY IN CHRONIC BRONCHITIS AND COPD.  L. Didon*¹, I. Qvarfordt¹, O. Andersson¹, M. Nord¹, G.C. Riise², ¹Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, SWEDEN; ²Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, SWEDEN.

MODIFIER ROLE OF NRF2 IN CIGARETTE SMOKE INDUCED EMPHYSEMA.  S. Biswal*¹, T. Rangasamy², R.M. Tuder², ¹Department of Environmental Health Sciences, Bloomberg School of Public Health; ²Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD.

MODIFIER ROLE OF NRF2 IN CIGARETTE SMOKE INDUCED EMPHYSEMA.  S. Biswal*¹, T. Rangasamy², R.M. Tuder², ¹Department of Environmental Health Sciences, Bloomberg School of Public Health; ²Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD.

NEUTROPHIL ELASTASE INCREASES MUC5AC MUCIN mRNA EXPRESSION VIA POST-TRANSCRIPTIONAL REGULATION.  S. Zheng¹, D.J. Kenan², B.M. Fischer¹, J.A. Voynow^{1, 2}, Departments of Pediatrics¹ and Pathology², Duke University Medical Center, Durham, NC.

PHENOTYPE CHARACTERIZATION BASED UPON HIGH-RESOLUTION COMPUTED TOMOGRAPHY (HRCT) FINDINGS AND REVERSIBILITY OF AIRFLOW LIMITATION IN COPD.  M. Nishimura*, H. Makita, Y. Nasuhara, N. Hizawa, T. Betsuyaku, Hokkaido COPD Study Group, First Department of Medicine, Hokkaido University School of Medicine, Sapporo, JAPAN.

DECREASED NUMBER OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN PATIENTS WITH EMPHYSEMA.  J-H. Lee*, D. Oh, Y. Chung, S-D. Lee, Division of Pulmonary and Critical Care Medicine, College of Medicine, Pochon CHA University, Seongnam, KOREA, National Medical Center, Seoul, KOREA, Asan Medical Center, College of Medicine University of Ulsan, Seoul, KOREA.

THE NATIONAL LUNG HEALTH EDUCATION PROGRAM (NLHEP).  D.E. Doherty*, G. Lawrence, L.M. Nett, T.L. Petty, National Lung Health Education Program, Dallas, TX, Lexington VA Medical Center and University of Kentucky Chandler Medical Center, Lexington, KY.

LYSYL OXIDASES ARE REQUIRED FOR NORMAL LUNG DEVELOPMENT AND GROWTH, BUT ALSO CONTRIBUTE TO PULMONARY FIBROSIS.  J. Xu*, J. Tian, E. Doherty, S. Berkelhammer, R. Tian, S.D. Shapiro, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital at Harvard Medical School, Boston, MA.

TRANSGENIC EXPRESSION OF HUMAN CUZN SUPEROXIDE DISMUTASE PREVENTS CIGARETTE SMOKE-INDUCED INFLAMMATION AND EMPHYSEMA FORMATION.  R.F. Foronjy*¹, O. Mirochnitchenko², V.L. Lemaitre¹, Y. Jia¹, M. Inouye², Y. Okada³, J.M. D'Armiento¹, ¹Columbia University, New York, NY, ²UMDNJ, Piscataway, NJ, and ³Keio University, Tokyo, JAPAN.

POLYMORPHISMS IN THE EXTRACELLULAR SUPEROXIDE DISMUTASE GENE AND PLASMA EC-SOD CONCENTRATIONS ARE ASSOCIATED WITH A DECREASED RISK OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE.  R.P. Bowler*¹, C. Wheeler¹, B. Duda¹, J.D. Crapo¹, E.D.Chan¹, S. Levy², ¹National Jewish Medical and Research Center, Denver, CO, ²J. Craig Venter Institute, Bethesda, MD.

PULMONARY HEMODYNAMICS IN COPD PATIENTS DURING EXERCISE AND EXACERBATION.  M. Ito*, M. Hanaoka, G. Ideura, S. Kanda, K. Urushihata, T. Koizumi, K. Fujimoto, K. Kubo, First Department of Medicine, Shinshu University School of Medicine, Matsumoto, JAPAN.

THE ROLE OF PHOSPHODIESTERASE 4 INHIBITORS IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD).  J.F. Donohue*, University of North Carolina, Chapel Hill, NC.

INTERSTITIAL AND PERIBRONCHIAL MACROPHAGES IN COPD DISPLAY AN ALTERNATIVELY ACTIVATED PHENOTYPE.  M.A. Voelkel*, J. Parr, C.M. Cool, M.W. Wynes, D.W.H. Riches, National Jewish Medical and Research Center, Denver, CO.

MATRIX METALLOPROTEINASE-9 AFFECT THE 3D COLLAGEN GEL CONTRACTION.  T. Kobayashi*, X.D. Liu, T. Kohyama, Q. Fang, F.Q Wen, S. Abe, J.A. Atkinson, J.M. Shipley, R.M. Senior, S.I. Rennard, Pulmonary, Critical Care and Sleep Medicine, University of Nebraska Medical Center, Omaha, NE; Washington University School of Medicine, St. Louis, MO.

ELEVATED ADENOSINE IN THE EXHALED AIR OF INDIVIDUALS WITH COPD.  A.K. Sullivan*, C. Ulson, R. Murphy, N. Voelkel, University of Colorado Denver, Denver, CO; National Jewish Medical and Research Center, Denver, CO.

PHOSPHODIESTERASE 4 INHIBITION IN ANIMAL MODELS OF COPD.  F. Cerasoli*¹, P.A. Martorana², G. Lungarella² L. Wollin³, R. Beume³. ¹ALTANA Pharma AG, Florham Park, NJ, ²Department of Physiopathology & Experimental Medicine, University of Siena, Siena, ITALY, ³ALTANA Pharma AG, Konstanz, GERMANY.

THE PDE4-INHIBITORS ROFLUMILAST AND ROLIPRAM MODULATE FIBROBLAST COLLAGEN-GEL CONTRACTION AND CHEMOTAXIS MEDIATED BY AUTOCRINE PGE2 SYNTHESIS INDUCED BY TGF-beta1.  S. Togo*, X. Liu, T. Kobayashi, R.F. Ertl, H. Sugiura, L.J. Shen, S.I. Rennard, Pulmonary, Critical Care and Sleep Medicine, University of Nebraska Medical Center, Omaha, NE.

ACUTE EFFECTS OF CIGARETTE SMOKE EXTRACT ON CXC CHEMOKINES AND MATRIX METALLOPROTEINASES RELEASED BY AIRWAY EPITHELIAL CELLS.  T. Gaddapara, M.O. Aksoy, S. Shahabuddin, R. Ji, Y. Yang, S.G. Kelsen*, Temple University School of Medicine, Philadelphia, PA.

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POSTER VIEWING
WINE AND CHEESE RECEPTION

Thursday, June 16, 2005 5:00-7:00 PM

POSTERS

EFFECTS OF HUMIC ACID PRE-LOADING IN A CIGARETTE-SMOKE MODEL OF EMPHYSEMA IN MICE.  T.J.A. van Eijl*¹, A.F. Ferreira¹, P.S. Lager¹, F. Kuper³, F.P. Nijkamp¹, N. Bloksma^{1, 2}, ¹Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, THE NETHERLANDS, ²Faculty of Biology, Utrecht University, Utrecht, THE NETHERLANDS, ³TNO Nutrition and Food Research Institute, Zeist, THE NETHERLANDS.

AEROSOLIZED HYALURONAN LIMITS THE PROGRESSION OF CIGARETTE SMOKE-INDUCED PULMONARY EMPHYSEMA IN MICE.  J. Cantor*, J. Cerreta, M. Ochoa, S. Ma, T. Chow, G. Grunig, G. Turino, St. John's University and St. Luke's-Roosevelt Hospital Center, New York, NY.

CONCENTRATION-DEPENDENT EFFECTS OF NITRIC OXIDE ON ANGIOGENESIS OF LUNG MICROVASCULAR ENDOTHELIAL CELLS: ROLE OF CALPAIN NITROSYLATION.  Y. Su*, J. Zhang, J.M. Patel, E.R. Block, Department of Medicine, Pulmonary Division, University of Florida College of Medicine, Gainesville, FL.

AN ANTIAPOPTOTIC ROLE FOR α1 ANTITRYPSIN IN THE PREVENTION OF EMPHYSEMA.  I. Petrache*¹, I. Fijalkowska², L. Zhen², T.R. Medler¹, J. Skirball¹, T. Flotte³, R.M. Tuder^{1, 2}, Division of Pulmonary and Critical Care Medicine, Department of Medicine¹, and Division of Cardiopulmonary Pathology, Department of Pathology², Johns Hopkins University School of Medicine, Department of Pediatrics, University of Florida³.

FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING REGULATES EXTRACELLULAR MATRIX GENE EXPRESSION DURING ALVEOGENESIS.  S. Srisuma, S. Bhattacharya, T. Andalcio, D.M. Simon, T.J. Mariani*, Pulmonary Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

ROLE OF CC CHEMOKINE RECEPTOR 5 IN GAMMA-INTERFERON-INDUCED AND CIGARETTE SMOKE-INDUCED EMPHYSEMA.  B. Ma*¹, R.J. Homer¹, C.G. Lee¹, Q.S. Chen¹, S. Chapoval¹, A. Coyle², J. Lora², D. Picarella², J.A. Elias¹, ¹Section of Pulmonary and Critical Care Medicine and Department of Pathology, Yale University, New Haven, CT; ²Millennium Pharmaceutical Inc., Boston, MA.

SURFACE ENHANCED LASER DESORPTION IONIZATION (SELDI)-TIME OF FLIGHT MASS SPECTROMETRY TO IDENTIFY A SUBSET OF PLASMA PROTEINS THAT ARE ASSOCIATED WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE.  R.P. Bowler*¹, B. Duda¹, ¹National Jewish Medical and Research Center, Denver, CO.

EGR-1 REGULATES CIGARETTE SMOKING INDUCED CHEMOKINE RELEASE VIA INDUCED HSP70 PATHWAY IN HUMAN LUNG FIBROBLASTS.  C.J. Li^{1, 2}, W. Ning¹, J.C. Yalowich³, D.J. Slebos¹, H.P. Kim¹, V.E. Kagan³, A.M.K. Choi¹, ¹Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine; ³Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA; ²Jiangsu Key Laboratory for Molecular Medical Biotechnology, Life Sciences College, Nanjing Normal University, Nanjing, CHINA.

REGULATION AND FUNCTION OF MITOCHONDRIAL HEME OXYGENASE-1 IN THE RESPIRATORY EPITHELIAL CELLS AFTER CIGARETTE SMOKE.  D.J. Slebos¹, H.F. Kauffman², H.P. Kim³, M. van der Toorn¹, S.W. Ryter³, D.S. Postma¹, A.M. Choi³, Departments of ¹Pulmonary Diseases and ²Allergology, University Hospital Groningen, THE NETHERLANDS and ³Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical School, PA.

IDENTIFICATION OF NEW MOLECULAR PATHWAYS INVOLVED IN THE PATHOGENESIS OF COPD BY PROTEOMICS APPROACHES.
R. Song, P.R. Reynolds, J. An, C. Feghali-Bostwick, J.C. Hogg*, A.M.K. Choi, University of Pittsburgh, Pittsburgh, PA, and St. Paul's Hospital-Providence Health Care, Vancouver, B.C., CANADA.

ADULT PULMONARY VASCULAR ENDOTHELIAL PRECURSORS RESIDE WITHIN THE MESENCHYMAL LUNG SP POPULATION.  S. Majka*, T. Lund, I. McNiece, C. Verfaillie, I. McMurtry, N. Voelkel, University of Colorado Denver, Denver, CO.

RNAi AGAINST STAT3 RESULTS IN CELL DEATH IN HUMAN BRONCHIAL EPITHELIAL CELLS EXPOSED TO CIGARETTE SMOKE EXTRACT.  X.D. Liu*, Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.

PERIPHERAL BLOOD MONONUCLEAR CELL PROFILING IN TOBACCO EXPOSURE: SUSCEPTIBILITY MARKERS FOR COPD.  M.P. Gruber*, C.D. Coldren, M.D. Woolum, M.W. Geraci, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Denver, CO.

SYSTEMIC BIOMARKER PATTERN IN DIFFERENT COPD PHENOTYPES INDEPENDENT OF SMOKING STATUS.  S.A. Patel*, A.M.K. Choi, Y. Zhang, N. Kaminski, A.E. Lokshin, J.L. Weissfeld, F.C. Sciurba, University of Pittsburgh Department of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Cancer Institute and University of Pittsburgh Graduate School of Public Health.

ROLE OF RTP801, A SUPPRESSOR OF THE mTOR PATHWAY IN CIGARETTE SMOKE-INDUCED PULMONARY INJURY IN MICE.  T. Yoshida*, L. Zhen¹, E. Brown, U. Chukwueke, A. Richter, I. Fijalkowska, J. Watkins, T. Rangasamy, P. Taneja, S. Biswal, I. Petrache, N. Notkin⁴, I. Mett⁴, E. Feinstein⁴, R.M. Tuder, ¹Division of Cardiopulmonary Pathology, Department of Pathology, School of Medicine, ²Department of Environmental Health Sciences, Bloomberg School of Public Health, ³Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, ⁴Quark Biotech, Inc., Fremont, CA.

VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) REGULATES CLEARANCE OF APOPTOTIC CELLS: IMPLICATIONS FOR EMPHYSEMA.  R.W. Vandivier*¹, R.M. Tuder², K. Morimoto¹, N.F. Voelkel¹, P.M. Henson¹, ¹Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Denver, CO, ²Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

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