2006 Annual Meeting
THOMAS L. PETTY
ASPEN LUNG CONFERENCE
49th Annual Meeting
June 7-10, 2006
Content
- Tuesday evening
- Wednesday morning
- Wednesday afternoon
- Thursday morning
- Thursday afternoon
- Friday morning
- Friday afternoon
- Saturday morning
- Poster Session
Given Institute - www.giveninstitute.org
Aspen, Colorado
Tuesday, June 6, 2006 -- Evening
5:00-7:00 PM
Evening Registration -- Wine and Cheese Reception Given Institute
Wednesday, June 7, 2006 -- Morning
8:00-8:15 AM
Introduction/Overview
Andrew P. Fontenot, M.D., Chair
Peter M. Henson, DVM,Ph.D.,M.D., Co-Chair
8:15-8:30 AM
Introduction
Thomas L. Petty, M.D.
Moderator - Andrew Fontenot, M.D.
8:30-9:15 AM
GILES F. FILLEY LECTURE "T CELL RECOGNITION" John W. Kappler, Ph.D. Department of Immunology National Jewish Medical and Research Center Denver, Colorado
9:15-9:30 AM
Discussion
9:30-9:45 AM
IDENTIFYING T CELL LIGANDS IN SARCOIDOSIS.
M.T. Falta*, F. Crawford, A. Geluk, T.H.M. Ottenhoff, J. Grunewald, P. Marrack, J.W. Kappler, A.P. Fontenot, Division of Clinical Immunology, University of Colorado Denver, Denver, CO.
9:45-10:00 AM
A MURINE MODEL OF T CELL-MEDIATED VASCULITIS.
D.C. Baiu*, B. Barger, B.J. Swanson, M.N. Hart, Department of Pathology, Medical School, University of Wisconsin, Madison, WI.
10:00-10:30 AM
Coffee Break
Moderator - Kevin Brown, M.D.
10:30-11:15 AM
STATE OF THE ART "Mechanisms of Scleroderma-Induced Lung Disease" Roland M. duBois, M.D. Royal Brompton Hospital, London, United Kingdom
11:15-11:30 AM
Discussion
11:30-11:45 AM
CORRELATION OF BAL CHEMOKINES WITH CLINICAL PARAMETERS IN SCLERODERMA LUNG DISEASE.
M.P. Keane*, J. Chung, W. Liu, R. Elashoff, J.A. Belperio, M.D. Roth, R.M. Silver, C. Strange, M. Sterz, P.J. Clements, D.E. Furst, D.A. Zisman, J. Goldin, M.D. Burdick, R.M. Strieter, D.P. Tashkin for the Scleroderma Lung Study Group, Divisions of Pulmonary and Critical Care Medicine, UCLA, Los Angeles and MUSC, SC.
11:45-12:00
SILICOSIS IS A CHRONIC INNATE IMMUNE RESPONSE DRIVEN BY MACROPHAGES AND NATURAL KILLER CELLS.
G. Davis1*, M. Poynter1, E. Hsu2, L. Pfeiffer1, D. Hemenway1, N. Kaminski2, M. Rincon1, University of Vermont, Burlington, VT1 and Pittsburgh University, Pittsburgh, PA2.
12:00-1:30 PM
.Lunch
Wednesday, June 7, 2006 -- Afternoon
Moderator – Raul M. Torres, Ph.D.
1:30-2:15 PM
PARKER B. FRANCIS LECTURESHIP "GENERATION OF AN IMMUNE RESPONSE" Marc K. Jenkins, Ph.D. Professor, Center for Immunology University of Minnesota Minneapolis, Minnesota
2:15-2:30 PM
Discussion
2:30-2:45 PM
RAPID LYMPHOCYTE RECRUITMENT AND INDUCTION OF THE LYMPHOCYTE CHEMOKINE CCL17 AFTER EPITHELIAL HYPERPASIA IN MOUSE LUNG.
J.W. Tichelaar*, H. Yin, S. Chowdhury, N.L. Harris, M.T. Borchers, University of Cincinnati, Department of Environmental Health, Cincinnati, OH.
2:45-3:00 PM
MICE DEFICIENT FOR LSC, A GENE INVOLVED IN LEUKOCYTE MIGRATION AND ADHESION, EXHIBIT LUNG PATHOLOGY SIMILAR TO HUMAN EMPHYSEMA.
J.M. Hartney1*, J. Brown1, J. Hu1, L-.Y. Chang2, R.P. Bowler2, R.M. Torres1, 1Integrated Department of Immunology and 2Department of Medicine, University of Colorado Denver and National Jewish Medical and Research Center, Denver, CO.
3:00-3:15 PM
LUNG INTERSTITIAL DENDRITIC CELLS INITIATE GRANULOMA FORMATION INDUCED BY PARTICULATE ANTIGEN BY PRIMING NAÏVE CD4 T CELLS IN THE MEDIASTINAL LYMPH NODES.
H.J. de Heer1, H. Hammad1, T. Soullié1, S. Jung2, M.A.M. Willart1, L. van Rijt1, B.N. Lambrecht1, H.C. Hoogsteden1*, 1Department of Pulmonary Medicine, Erasmus MC, Rotterdam, the Netherlands, and 2The Weizmann Institute of Science, Department of Immunology, Rehovot, Israel.
3:15-3:45 PM
Break
Moderator - Mark Nicolls, M.D.
3:45-4:30 PM
STATE OF THE ART "Immune Reconstitution After Autologous Keith M. Sullivan, M.D. Stem Cell Transplantation" Duke University Medical Center
4:30-4:45 PM
Discussion
4:45-5:00 PM
A NEW MODEL OF AIRWAY TRANSPLANTATION TO EVALUATE EARLY INFLAMMATORY EVENTS, FIBROPROLIFERATION AND EPITHELIAL MESENCHYMAL TRANSFORMATION (EMT).
A. Babu*, T. Murakawa, M. Zamora, F. Grover, M. Kerklo, M. Nicolls, University of Colorado Denver, Denver, CO.
5:00-5:15 PM
SINGLE NUCLEOTIDE POLYMORPHISM HAPLOTYPES IN THE BACTERICIDAL/ PERMEABILITY INCREASING PROTEIN GENE INFLUENCES THE RISK OF DEVELOPING RAPID AIRFLOW DECLINE AFTER HEMATOPOIETIC CELL TRANSPLANTATION.
J.W. Chien1*, L.P. Zhao2, J.A. Hansen1, W.H. Fan2, T. Parimon1, J.G. Clark1, 1Clinical Research Division, Pulmonary and Critical Care Section Fred Hutchinson Cancer Research Center, Seattle, WA and 2Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
5:15 PM
POSTER VIEWING --- SOCIAL HOUR
Thursday, June 8, 2006 -- Morning
Moderator - Karen Fagan, M.D.
8:00-8:45 PM
ROGER S. MITCHELL LECTURE "Rheumatoid Lung Disease" Kevin K. Brown, M.D. Department of Medicine National Jewish Medical and Research Center Denver, Colorado
8:45-9:00 AM
Discussion
9:00-9:15 AM
THE ANTISYNTHETASE SYNDROME: AN UNDER-RECOGNIZED ETIOLOGY OF INTERSTITIAL LUNG DISEASE.
S.K. Danoff*, L Christopher-Stine, M.R. Horton, Johns Hopkins University, School of Medicine, Baltimore, MD.
9:15-9:30 AM
TIRAP IS A CRITICAL MEDIATOR OF ANTIBACTERIAL DEFENSE IN THE LUNG AGAINST KLEBSIELLA PNEUMONIA BUT NOT PSEUDOMONAS AERUGINOSA.
S. Jeyaseelan1,2,* S.K. Young1, M. Yamamoto3, S. Akira3, J.K. Kolls4, G.S. Worthen1,2, 1Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, Denver, CO; 2Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Denver, CO; 3Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; 4Children’s Hospital of Pittsburgh, Laboratory of Lung Immunology and Host Defense, Pittsburgh, PA.
9:30-9:45 AM
IL-23 AND IL-17 MEDIATE AIRSPACE INFLAMMATION IN A CHRONIC MODEL OF MUCOID PSEUDOMONAS AERUGINOSA PULMONARY INFECTION. P.J. Dubin1*, L. Ulrich1, T. Dubowski1, N. Ghilardi2, J.K. Kolls1, 1Department of Pediatrics, The University of Pittsburgh, Pittsburgh, PA and 2Genentech, South San Francisco, CA.
9:45-10:15 AM
Coffee Break
Moderator - David W.H. Riches, Ph.D.
10:15-11:00 AM
STATE OF THE ART "Mechanisms of Fibrosis" Gary W. Hunninghake, M.D. University of Iowa Roy J. and Lucille A. Carver College of Medicine
11:00-11:15 AM
Discussion
11:15-11:30 AM
CHEMOKINE REGULATION OF MACROPHAGE APOPTOSIS AND DENDRITIC CELL TRAFFIC.
M.H. Grayson*, E.Y. Kim, M.J. Holtzman, Divisions of Allergy and Pulmonary Medicine, Department of Medicine and Department of Cell Biology, Washington University School of Medicine, St. Louis, MO.
11:30-11:45 AM
MUTANT P53 EXPRESSION IN THE LUNG EPITHELIUM CAUSES DOSE-DEPENDENT MODULATION OF INTERSTITIAL LUNG DISEASE PROGRESSION INITIATED BY TRANSFORMING GROWTH FACTOR-ß-EXPRESSING ADENOVIRUS.
G.F. Morris*, A. Notwick, D.A. Pociask, A.R. Brody, Program in Lung Biology, Department of Pathology, Tulane University Health Sciences Center, New Orleans, LA.
11:45-12:00
AMPLIFIED IMMUNE AND FIBROTIC RESPONSES IN HERMANSKY PUDLAK MICE.
L.R. Young*, M.T. Borchers, R. Pasula, F.X. McCormack, Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.
12:00 Noon
Instructions for Picnic
12:30 PM
Picnic at East Maroon Bells Portal
Friday, June 9, 2006 -- Morning
Moderator - Lisa A. Maier, M.D.
8:00-8:45 AM
STATE OF THE ART "Lessons Learned from ACCESS" Milton D. Rossman, M.D. University of Pennsylvania Medical Center
8:45-9:00 AM
Discussion
9:00-9:15 AM
TOLL-LIKE RECEPTOR EXPRESSION AND CYTOKINE SECRETION AFTER IN VITRO STIMULATION OF LUNG AND BLOOD CELLS IN SARCOIDOSIS.
M. Wikén, J. Grunewald, A. Eklund, J. Wahlström*, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
9:15-9:30 AM
IL-4 mRNA STABILITY IS MEDIATED BY RNA-BINDING PROTEIN
HuR. T.O. Yarovinsky, N.S. Butler, M.P. Mohning, M.M. Monick, G.W. Hunninghake*, University of Iowa Roy J. and Lucille A. Carver College of Medicine and VAMC, Iowa City, IA.
9:30-10:00 AM
Coffee Break
Moderator - Lee S. Newman, M.D.
10:00-10:45 AM
THOMAS A. NEFF LECTURE "GENETICS OF SARCODOSIS" Michael C. Iannuzzi, M.D. Professor, Medicine/Pulmonary and Critical Care Mount Sinai Medical Center New York, New York
10:45-11:00 AM
Discussion
11:00-11:15 AM
GENETIC PREDISPOSITION TO SARCOIDOSIS UVEITIS: ROLE OF HEAT-SHOCK PROTEINS 70 (HSP70) GENETIC POLYMORPHISMS.
P. Spagnolo1*, H. Sato1, S.E. Marshall1, A.U. Wells1, K.M. Antoniou1, R.M. duBois1, K.I Welsh1, 1Interstitial Lung Disease Unit, Royal Brompton Hospital, Imperial College, London, UK.
11:15-11:30 AM
HLA-DQB1*0602 ALLELE IS ASSOCIATED WITH SPLENOMEGALY IN JAPANESE SARCOIDOSIS.
H. Sato1*, S. Nagai2,3, T. Handa2, Y. Suginoshita4, K. Ohta3, K.I. Welsh1, R.M. du Bois1, T. Izumi3, 1Interstitial Lung Disease Unit, Royal Brompton Hospital and Imperial College, London, UK; 2Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, JAPAN; 3Central Clinic in Kyoto, Kyoto, JAPAN; 4Department of Gastroenterology, Graduate School of Medicine Kyoto University, Kyoto, JAPAN.
11:30-11:45 AM
RSV ACTIVATES MDM2 CAUSING DECREASED p53 PROTEIN FOLLOWED BY TYPE 1 INTERFERON-MEDIATED RECOVERY OF p53 IN AIRWAY EPITHELIAL CELLS.
D. Groskreutz*, M.M. Monick, L. Powers, T.O. Yarovinsky, G.W. Hunninghake, The University of Iowa Carver College of Medicine and Veterans Administration, Iowa City, IA.
11:45-1:30 PM
Lunch
Friday, June 9, 2006 -- Afternoon
Moderator - Peter M. Henson, DVM, Ph.D., M.D.
1:30-2:15 PM
STATE OF THE ART "Role of CD4+ T Cells in Sarcoidosis" Johan Grunewald, M.D.,Ph.D. Karolinska Institute, Stockholm, Sweden
2:15-2:30 PM
Discussion
2:30-2:45 PM
A ROLE FOR REACTIVE OXYGEN SPECIES IN BERYLLIUM-INDUCED LYMPHOCYTE PROLIFERATION.
A.P. Fontenot2,3, R.T. Sawyer1,2, D.R. Dobis1, G.B. Pott2, L.A. Maier1,2,4, L.S. Newman1,2,4,, B.J. Day1,2,3*, Department of Medicine1, National Jewish Medical and Research Center, Departments of Medicine2, Immunology3, and Preventive Medicine and Biometrics4, University of Colorado Denver, Denver, CO.
2:45-3:00 PM
CIGARETTE SMOKE EXTRACT SUPPRESSES MATURATION-ASSOCIATED DENDRITIC CELL INTERLEUKIN-12 PRODUCTION THROUGH OXIDATIVE STRESS.
P.R. Kroening, R. Vassallo*, Mayo Clinic and Foundation, Rochester, MN.
3:00-3:15 PM
A MURINE MODEL OF PULMONARY FIBROSIS USING CHRONIC EXPOSURE TO BACILLUS SUBTILIS.
P.L. Simonian*, C.L. Roark, R.L. O’Brien, A.P. Fontenot, University of Colorado Denver, Denver, CO, and National Jewish Medical and Research Center, Denver, CO.
3:15-3:45 PM
Break
Moderator - Brian L. Kotzin, M.D.
3:45-4:30 PM
STATE OF THE ART "Potential Etiologic Agents in Sarcoidosis" David R. Moller, M.D. Johns Hopkins Asthma and Allergy Center
4:30-4:45 PM
Discussion
4:45-5:00 PM
IMMUNE RECOGNITION OF MYCOBACTERIUM ESAT-6 ANTIGENS IS ASSOCIATED WITH HLA-DRB1*1101 IN SYSTEMIC SARCOIDOSIS.
W.P. Drake1*, M.S. Dhason2, H. Sato3, B.E. Shepherd4, S. Vivedulu1, R. Hajizadeh1, L.S. Newman5, S.A. Kalams1,6, 1Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, 2Department of Biological Sciences, University of Arkansas, 3Clinical Genomics Group, Imperial College, London, 4Department of Biostatistics, Vanderbilt University School of Medicine, 5Department of Preventive Medicine and Biometrics, University of Colorado Denver, Denver, CO, 6Department of Microbiology and Immunology, Vanderbilt University School of Medicine.
5:00-5:15 PM
PULMONARY GRANULOMATOUS INFLAMMATION IN RESPONSE TO MYCOBACTERIAL CATALASE-PEROXIDASE PROTEIN: AN EXPERIMENTAL MODEL OF SARCOIDOSIS.
E.S. Chen1*, Y. Zhang2, D.R. Moller1, 1,Department of Medicine and 2Bloomberg School of Public Health; Johns Hopkins University, Baltimore, MD.
5:15 PM
Adjourn
Saturday, June 10, 2006 -- Morning
Moderator - Andrew P. Fontenot, M.D.
8:00-8:45 AM
STATE OF THE ART "Biologics in the Treatment of Immunologic Lung Disease" Brian Kotzin, M.D. Amgen, Thousand Oaks, California
8:45-9:00 AM
Discussion
9:00-9:15 AM
LONG-TERM DEPLETION OF B CELLS IS AN EFFECTIVE AND SAFE TREATMENT OPTION FOR PATIENTS WITH CHRONICALLY RELAPSING WEGENER’S GRANULOMATOSIS.
J.M. Golbin*, K.A. Keogh, F.C. Fervenza, S.R. Ytterberg, U. Specks, Mayo Clinic, Rochester, MN.
9:15-9:30 AM
NOVEL INTERACTIONS BETWEEN TGFß AND SERUM RESPONSE FACTOR NETWORKS: IMPLICATIONS FOR ASTHMA.
B. Camoretti-Mercado*, J. Churchill, S. Dewndara, C.G. Lee, J.A. Elias, J. Solway, University of Chicago, Chicago, IL and Yale University, New Haven, CT.
9:30-9:45 AM
NKG2D LIGANDS IN THE DEVELOPMENT OF COPD.
M.T. Borchers*, N.L. Harris, J.W. Tichelaar, K. Fogel, D. McGraw, University of Cincinnati College of Medicine, Cincinnati, OH.
9:45-10:15 AM
Coffee Break
10:15-11:30 AM
CONFERENCE SUMMARY Philippa Marrack, Ph.D. Investigator, Howard Hughes Medical Institute Professor, Integrated Department of Immunology National Jewish Medical and Research Center Denver, Colorado, USA
POSTER VIEWING -- SOCIAL HOUR
Wednesday, June 7, 2006 5:15 PM
POSTERS
CIGARETTE SMOKING MODULATES T CELL RESPONSES IN LUNG AND MESENTERIC LYMPH NODES.
A.A. Frazer-Abel*, S. Lazis, J. Harvey, B.M. Freed, Department of Medicine, Division of Allergy and Clinical Immunology, University of Colorado Denver, Denver, CO.
INFLAMMATION IN PULMONARY VASCULAR REMODELING.
G. Grunig1*, E. Grunig2, E. Daley1, K. Robinson1, V.P. Kurup3, C. Hogaboam4, P. Lincoln4, L. Taraseviciene-Stewart5, N.F. Voelkel5, 1Columbia University, St. Luke’s Roosevelt Hospital, New York, NY, 2University of Heidelberg, GERMANY, 3Medical College of Wisconsin, VA Medical Center, Milwaukee, WI, 4University of Michigan, Ann Arbor, MI, and 5University of Colorado, Denver, CO.
LYMPHOCYTE MEDIATED INFLAMMATION IN A MURINE LUNG INJURY REPAIR MODEL.
P.I. Simonian*; F. Diaz del Valle, A. Fontenot, N.F. Voelkel, I.S. Douglas, University of Colorado Denver, Denver, CO.
IMMUNE RECOGNITION OF MYOCBACTERIAL ANTIGEN 85A BY SARCOIDOSIS PERIPHERAL BLOOD MONONUCLEAR CELLS.
W.P. Drake1, R. Hajizadesh1*, J. Carlisle1, M.T. Nadaf1, B.E. Shepherd2, S.A. Kalams1,3, 1Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, 2Department of Biostatistics, Vanderbilt University School of Medicine, 3Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN.
EFFECTS OF PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR-a, ? AGONISTS ON ACUTE LUNG INJURY RATS INDUCED BY LIPOPOLYSACCHARIDE.
J. Wang*, P. Jiang, G. Qain, Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, CHINA.
BERYLLIUM-INDUCED TNF-a PRODUCTION IS TRANSCRIPTION-DEPENDENT IN BERYLLIUM DISEASE.
B.C. Tooker1*, R.T. Sawyer2, A.P. Fontenot3,4,5,6, T.A. Barnes7, C.E. Parsons7, L.A. Maier1,3,7, M.M. Gillespie7, E.B. Gottschall1,3,7, L Silveira1,7, J. Hagman5, L.S. Newman1,3,4, 1Department of Preventive Medicine and Biometrics, University of Colorado Denver, Denver, CO, 2Division of Allergy, Immunology and Transplantation, NIAID, National Institutes of Health, Bethesda, MD, 3Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, 4Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Denver, Denver, CO, 5Integrated Department of Immunology, National Jewish Medical and Research Center, 6Department of Immunology, University of Colorado Denver, Denver, CO and 7Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, CO.
THE IL-13Ra2 RECEPTOR ATTENUATES LUNG INJURY AND REMODELING.
J.A. Belperio, H. Nakamura, Y.Y. Xue, J. Pan, M.D. Burdick, R.M. Strieter, M.P. Keane*, Division of Pulmonary and Critical Care Medicine, UCLA, Los Angeles, CA.
PSEUDOMONAS MODULATES TNF-a INDUCED KUPFFER CELL INFLAMMATION AND APOPTOSIS.
A. Ashare*, T. Yarovinsky, L.S. Powers, M.M. Monick, G.W. Hunninghake, University of Iowa Roy J. and Lucille A. Carver College of Medicine and VAMC, Iowa City, IA.
FUNCTIONAL AND PHENOTYPIC CHARACTERIZATION OF CD57+ CD4+ T CELLS AND THEIR ASSOCIATION WITH CHRONIC BERYLLIUM DISEASE.
B.E. Palmer*, D. Mack, A. Martin, A.P. Fontenot, Departments of Medicine and Immunology, University of Colorado Denver, Denver, CO.
Aspen Lung Conference
- To provide an international forum for leading clinicians and researcher to exchange of ideas relating to clinical problems and research of the lung.
- To fill a recognized need in a field where knowledge is doubling every five years.
- To focus on a single topic, exhaustively reviewing it with significant time allowed for discussion.
- To provide the stimulus and impetus to further research in pulmonary medicine.
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4200 East 9th Avenue
Box C272
Denver, Colorado 80262 USA