Faculty

Edward David Chan, M.D.
Associate Professor of Medicine

EDUCATION/TRAINING

University of Colorado, Colorado Springs, CO
1982B.A.Biology/Chemistry

Columbia University College of Physicians & Surgeons, New York, NY
1986M.D.

St. Lukes-Roosevelt Hospital Center, Univ. Hosp, New York, NY
1986-1989ResidencyInternal Medicine

University of Colorado Denver, Denver, CO
1993-1997FellowshipPulmonary Science & Critical Care Medicine

 UCD
4200 E. Ninth Ave.
Denver, CO 80262
Tel: 303.398.1491
chane@njc.org

PROFESSIONAL EXPERIENCE

1989-1991
Chief of Internal Medicine Clinic, Clinical Laboratory Director, CME Coordinator; F.E. Warren Air Force Base Hospital, Cheyenne, WY

1991-1993
Staff Internist, Infection Control Committee Chairman, QA Monitor of Internal Medicine Clinic; United States Air Force Academy Hospital, Colorado Springs, CO

1993-1997
Pulmonary and Critical Care Fellow, University of Colorado Denver, Denver, CO

1994-1999
Pulmonary Research Fellow, National Jewish Medical and Research Center, Denver, CO

1997-Present
Compensation and Pension Examiner, Denver Veteran Administration Medical Ctr, Denver, CO

1998-Present
Triage Attending, National Jewish Medical and Research Center, Denver, CO

1999-Present
Clinical Staff Member, National Jewish Medical and Research Center, Denver, CO

SELECTED PUBLICATIONS

  1. Chan ED. Reye's syndrome in a young adult. Military Medicine 1993; 158: 65-68.
  2. Chan ED, Welsh CH. Fulminant Mycoplasma pneumoniae pneumonia: A review of the English literature. West J Med 1995; 162: 133-142.
  3. Chan ED, Irvin CG. The detection of collapsible airways contributing to airflow limitation. Chest 1995; 107: 856-859.
  4. Chan ED, Terada LS, Schwarz MI. Sarcoidosis presenting with prolonged fever in a patient with sickle cell anemia. J Natl Med Assoc 1995; 87: 826-828.
  5. Chan ED, Wilson ML, Neff TA. Pulmonary botryomycosis: Its relationship to actinomycosis and to chronic aspiration pneumonia. Clin Pulm Med 1996; 3: 67-71.
  6. Veatch M, Wanger J, Chan ED. Lessons from spirometry: Look at the picture. Respir Care 1996; 41: 745-747.
  7. Riches DWH, Chan ED, Winston BW. TNF-a-induced regulation and signalling in macrophages. Immunobiol. 1996; 195: 477-490.
  8. Rose DM, Winston BW, Chan ED, Riches DWH, Gerwins P, Johnson GL, Henson PM. Fcg-receptor cross-linking activates p42, p38, and JNK mitogen-activated protein kinases (MAPK) in murine macrophages: Role for p42MAPK in Fcg receptor-stimulated TNF-a synthesis. J Immunol 1997; 158: 3433-3438.
  9. Leu CY, Lynch DA, Chan ED. The case of the torpid thoracic tumor. Chest 1997; 112: 535-537.
  10. Rose DM, Winston BW, Chan ED, Riches DWH, Henson PM. Interferon-g and transforming growth factor-b modulate the activation of mitogen-activated protein kinases and tumor necrosis factor-a production induced by Fcg-receptor stimulation in murine macrophages. Biochem Biophys Res Comm 1997; 238: 256-260.
  11. Chan ED, Hodges TN, Parsons PE. Sudden respiratory insufficiency in a previously healthy 47 year-old man. Chest 1997; 112:1419-1422.
  12. Winston BW, Chan ED, Riches DWH. Activation of pp38mapk, MKK3, and MKK4 by tumor necrosis factor-alpha in mouse bone marrow-derived macrophages. J Immunol 1997; 159: 4491-4497.
  13. Chan ED, Winston BW, Jarpe MB, Wynes MW, Riches DWH. Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNFa Proc Natl Acad Sci USA 1997; 94: 13169-13174.
  14. Schwarz MI, Zamora MR, Hodges TN, Chan ED, Bowler RP, Tuder RM. Isolated pulmonary capillaritis and diffuse alveolar hemorrhage in rheumatoid arthritis and mixed connective tissue disease. Chest 1998; 113: 1609-1615.
  15. Nowbar S, Ridout E, Chan ED. A 60 year-old man with septic arthritis and hypotension after a fall. Chest 1999; 115: 883-885.
  16. Uh S-T, Inoue Y, King TE Jr, Chan ED, Newman LS, Riches DWH. Morphometric analysis of insulin-like growth factor-I in lung tissues of patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998; 158: 1626-1635.
  17. Riches DWH, Chan ED, Zahradka EA, Winston BW, Remigio LK, Lake FR. Cooperative signaling by tumor necrosis factor receptors CD120a (p55) and CD120b (p75) in the expression of nitric oxide and inducible nitric oxide synthase by mouse macrophages. J Biol Chem 1998; 273: 22800-22806.
  18. Chan ED, Welsh CH. Geriatric Respiratory Medicine. Chest 1998; 114: 1704-1733.
  19. Chan ED, Winston BW, Terada LS, Parsons PE. The Bedside Critical Care Manual, Philadelphia, Hanley & Belfus, 1998.
  20. Chan ED, Worthen GS, Augustin A, Lapadat R, Riches DWH. Inflammation in the pathogenesis of interstitial lung disease. In Schwarz MI, King TE, Jr, eds. Interstitial Lung Disease. Hamilton, Ontario: B.C. Decker Inc., Third Edition, 1998: 135-164.
  21. Chan ED, Winston BW, Uh S-T, Wynes MW, Rose DM, Riches DWH. Evaluation of the Role of Mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFNg and TNFa in mouse macrophages. J Immunol 1999; 162: 415-422.
  22. Chan ED, Kalayanamit T, Lynch DA, Tuder R, Arndt P, Winn R, Schwarz MI. Mycoplasma pneumoniae-associated bronchiolitis causing severe restrictive lung disease in adults: Report of three cases and literature review Chest 1999; 115: 1188-1194.
  23. Chan ED and Riches DWH. Potential role of the JNK/SAPK signal transduction pathway in the induction of iNOS by TNFa. Biochem Biophys Res Comm 1998; 253: 790-796.
  24. Chan ED, Iseman MD. Potential association between calcified thoracic lymphadenopathy due to prior Histoplasma capsulatum infection and pulmonary Mycobacterium avium complex (MAC) disease: A retrospective observation of 79 MAC cases. Southern Med J 1999; 92: 572-576.
  25. Chan ED, Hermanoff MA, Connick E. Lemierre's postanginal sepsis in an "older" patient: Case report and review of the English literature over the past twenty-five years. Clin Pulm Med 1999; 6: 333-338.
  26. Chan ED, Winston BW, Uh S-T, Remigio LK, Riches DWH. Systematic evaluation of the mitogen-activated protein kinases in the induction of iNOS by tumor necrosis factor-alpha and interferon-gamma. Chest 1999; 116: 91S-92S.
  27. Sharma SK, Chan ED. Lung disease in the elderly: Diagnosing asthma. J Respir Dis 2000; 21: 101-113.
  28. O'Driscoll CM, Chan ED, Fernandez E. Imaging of emphysema. In Lynch DA, Newell JD, Jr, and Lee JS, eds. Imaging of Diffuse Lung Disease. Toronto, B.C.Decker Inc., 1999 (pp 199-233).
  29. Newell JD Jr, Chan ED, Martin RJ. Imaging of airway disease. In Lynch DA, Newell JD, Jr, and Lee JS, eds. Imaging of Diffuse Lung Disease. Toronto, B.C.Decker Inc., 1999 (pp 171-197).
  30. Chan ED, Reves R, Belisle JT, Brennan PJ, Hahn WE. Diagnosis of tuberculosis by a visually detectable immunoassay for lipoarabinomannan. Am J Respir Crit Care Med 2000; 161: 1713-1719.
  31. Minamino T, Yujiri T, Papst PJ, Chan ED, Johnson GL, Terada N. Gene disruption of MEKK1 accelerates cardiac myocyte apoptosis by oxidative stress through increasing TNFa production. Proc Natl Acad Sci USA 1999; 96: 15127-15132.
  32. Yujiri T, Ware M, Widmann C, Oyer R, Russell D, Chan ED, Zaitsu Y, Clarke P, Tyler K, Oka Y, Fanger GR, Henson P, Johnson GL. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NFkB activation. Proc Natl Acad Sci USA 2000; 97: 7272-7277.