Faculty

LingYi L. Chang, Ph.D.
Associate Professor of Medicine

EDUCATION/TRAINING

National Taiwan University
1970B.S.Entomolgy

North Carolina State University, Raleigh, NC
1970M.S.Physiology
1982Ph.D.Physiology

 UCD
4200 E. Ninth Ave.
Denver, CO 80262
Tel: 303.398.1423
changl@njc.org

PROFESSIONAL EXPERIENCE

1981 to 1984
Research Associate, Division of Allergy, Critical Care and Respiratory Medicine, Duke University Medical Center, Durham, North Carolina

1984 to 1987
Medical Research Associate, Department of Medicine, Duke University Medical Center, Durham, North Carolina

1987 to 1993
Assistant Research Professor of Medicine, Duke University, Durham, North Carolina

1989 to 1997
Associate Research Professor of Medicine, Duke University, Durham, North Carolina

1993 to 1997
Associate Research Professor of Medicine, Duke University, Durham, North Carolina

1997 to Present
Associate Faculty Member, National Jewish Medical and Research Center, Denver, Colorado

1997 to Present
Associate Professor, Department of Medicine, University of Colorado Denver, Denver, Colorado

SELECTED PUBLICATIONS

  1. Radi R, Turrens JF, Chang L-Y, Bush KM, Crapo JD and Freeman BA. Detection of catalase in rat heart mitochondria. J Biol Chem 266:22028-22034, 1991.
  2. Chang L-Y, Huang Y, Stockstill BL, Graham JA, Grose EC, Ménache MG, Miller FJ, Costa DL and Crapo JD. Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone. Toxicol Appl Pharmacol 115:241-252, 1992.
  3. Crapo JD, Oury T, Rabouille C, Slot JW and Chang L-Y. Copper, zinc superoxide dismutase is primarily a cytosolic protein in human cells. Proc Natl Acad Sci USA 89:10405-10409, 1992.
  4. Kinnula VL, Chang L-Y, Everitt JI and Crapo JD. Oxidants and antioxidants in alveolar epithelial type II cells: In situ, freshly isolated and cultured cells. Am J Physiol:Lung Cell Mol Physiol 262:L69-L77, 1992.
  5. Kinnula VL, Everitt JI, Mangum JB, Chang L-Y and Crapo JD. Antioxidant defense mechanisms in cultured pleural mesothelial cells. Am J Respir Cell Mol Biol 7:95-103, 1992.
  6. Kinnula VL, Whorton AR, Chang L-Y and Crapo JD. Regulation of hydrogen peroxide generation in cultured endothelial cells. Am J Respir Cell Mol Biol 6:175-182, 1992.
  7. Wispé JR, Warner BB, Clark JC, Dey CR, Neuman J, Glasser SW, Crapo JD, Chang L-Y and Whitsett JA. Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury. J Biol Chem 267:23937-23941, 1992.
  8. Clyde BL, Chang L-Y, Auten RL, Ho YS and Crapo JD. Distribution of manganese superoxide dismutase mRNA in normal and hyperoxic rat lung. Am J Respir Cell Mol Biol 8:530-537, 1993.
  9. Kang BH, Crapo JD, Wegner CD, Letts LG and Chang L-Y. Intercellular adhesion molecule-1 expression on the alveolar epithelium and its modification by hyperoxia. Am J Respir Cell Mol Biol 9:350-355, 1993.
  10. Liou W, Chang L-Y, Geuze HJ, Strous GJ, Crapo JD and Slot JW. Distribution of CuZn superoxide dismutase in rat liver. Free Radic Biol Med 14:201-207, 1993.
  11. Kinnula VL, Yankaskas JR, Chang L-Y, Virtanen I, Linnala A, Kang BH and Crapo JD. Primary and immortalized (BEAS 2B) human bronchial epithelial cells have significant antioxidative capacity in vitro. Am J Respir Cell Mol Biol 11:568-576, 1994.
  12. Oury TD, Chang L-Y, Marklund SL, Day BJ and Crapo JD. Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab Invest 70:889-898, 1994.
  13. Vincent R, Chang L-Y, Slot JW and Crapo JD. Quantitative immunocytochemical analysis of Mn SOD in alveolar type II cells of the hyperoxic rat. Am J Physiol 267:L475-L481, 1994.
  14. White CR, Brock TA, Chang L-Y, Crapo JD, Briscoe P, Ku D, Bradley WA, Gianturco SH, Gore J and Freeman BA. Superoxide and peroxynitrite in atherosclerosis. Proc Natl Acad Sci USA 91:1044-1048, 1994.
  15. Young SL, Chang L-Y and Erickson HP. Tenascin-C in rat lung: Distribution, ontogeny and role in branching morphogenesis. Dev Biol 161:615-625, 1994.
  16. Benov L, Chang L-Y, Day B and Fridovich I. Copper, zinc superoxide dismutase in Escherichia coli: Periplasmic localization. Arch Biochem Biophys 319:508-511, 1995.
  17. Chang L-Y, Kang BH, Slot JW, Vincent R and Crapo JD. Immunocytochemical localization of the sites of superoxide dismutase induction by hyperoxia in rat lungs. Lab Invest 73:29-39, 1995.
  18. Day BJ, Evans KS, Kang BH, Chang L-Y, Wegner CD and Crapo JD. Immunolocalization of inhaled recombinant human manganese superoxide dismutase reveals a prolonged retention in lung surface lining fluids. Inhal Toxicol 7:1109-1120, 1995.
  19. Pietarinen P, Raivio K, Devlin RB, Crapo JD, Chang L-Y and Kinnula VL. Catalase and glutathione reductase protection of human alveolar macrophages during oxidant exposure in vitro. Am J Respir Cell Mol Biol 13:434-441, 1995.
  20. Stockstill BL, Chang L-Y, Ménache MG, Mellick PW, Mercer RR and Crapo JD. Bronchiolarized metaplasia and interstitial fibrosis in rat lungs chronically exposed to high ambient levels of ozone. Toxicol Appl Pharmacol 134:251-263, 1995.
  21. Kang BH, Manderschied BD, Huang YC, Crapo JD and Chang L-Y. Contrasting response of lung parenchymal cells to instilled TNFa and IFNg: The inducibility of specific cell ICAM-1 in vivo. Am J Respir Cell Mol Biol 15:540-550, 1996.
  22. Oberdörster G, Finkelstein J, Ferin J, Godleski J, Chang L-Y, Gelein R, Johnston C and Crapo JD. Ultrafine particles as a potential environmental health hazard. Studies with model particles. Chest 109:68S-69S, 1996.
  23. Su WY, Day BJ, Kang BH, Crapo JD, Huang YC and Chang L-Y. Lung epithelial cell-released nitric oxide protects against PMN-mediated cell injury. Am J Physiol 271:L581-L586, 1996.
  24. Brady TC, Chang L-Y, Day BJ and Crapo JD. Extracellular superoxide dismutase is upregulated with inducible nitric oxide synthase after NF-k B activation. Am J Physiol 273:L1002-L1006, 1997.
  25. Su WY, Folz R, Chen JS, Crapo JD and Chang L-Y. Extracellular superoxide dismutase mRNA expressions in the human lung by in situ hybridization. Am J Respir Cell Mol Biol 16:162-170, 1997.
  26. Welty-Wolf KE, Simonson SG, Huang YCT, Kantrow SP, Carraway MS, Chang L-Y, Crapo JD and Piantadosi CA. Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis. J Appl Physiol 83:559-568, 1997.
  27. Que LG, Kang BH, Huang YC, Piantadosi CA and Chang L-Y. Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis. Shock 9:304-309, 1998.
  28. Day BJ, Patel M, Calavetta L, Chang L and Stamler JS. A mechanism of paraquat toxicity involving nitric oxide synthase. Proceedings of the National Academy of Science, USA. 96: 12760-12765, 1999.
  29. Ahmad S, Allen CB, Chang L, Schneider BK and White CW. Clutamine protects mitochondrial structure and function in oxygen toxicity. Am J Physiol, 280:L779 - L791, 2001.
  30. Oury TD, Thakker K, Chang L, Crapo JD, Day BJ, Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin. Am J Respir Cell Mol Biol. In Press, 2001.
  31. Chien MM, Chang L and Freed JH. Receptor-mediated oncosis in primary B cells. Immunology, Submitted, 2001.
  32. Ahmad A, Ahmad S, Schneider BK, Allen CB, Chang L and CW White. Elevated expression of hexokinase-II protects human lung epithelial-like A549 cells against oxidative injury. Am J Physiol Lung Cell Mol Physiol, Submitted 2001.
  33. Chang L, Subramaniam M, Yoder BA, Day BJ, Coalson JJ, Sunday ME and Crapo JD. A catalytic antioxidant Metalloporphyrin Prevents Alveoalr Structural Remodeling In A Baboon Model of Bronchopulmonary Dysplasia. J Clin Invest, Submitted, 2001.