Faculty


Dwight John Klemm, Ph.D.
Associate Professor of Medicine

EDUCATION/TRAINING

University of New Mexico, Albuquerque, NM
1981B.S.Biology
1986Ph.D.Biochemistry

Case Western Reserve Univeristy
1990Post-DocBiochemistry
UCD
4200 E. Ninth Ave.
Denver, CO 80262
Tel: 303.399.8020 x2778
Dwight.Klemm@uchsc.edu

PROFESSIONAL EXPERIENCE

March 2001 – Present
Associate Professor, University of Colorado Denver, Cardiovascular Pulmonary Research Laboratory

March 2001 – Present
Director of Basic Research, Veterans Affairs Medical Center, Pulmonary and Critical Care Section and Senior Research Biologist Research Service

July 1999 - Present
Associate Faculty Member, National Jewish Medical and Research Center, Department of Medicine, Division of Allergy and Clinical Immunology

July 1999 - Present
Adjunct Associate Professor, University of Colorado Denver, Department of Biochemistry and Molecular Genetics

July 1996 - June 1999
Assistant Faculty Member, National Jewish Center for Immunology and Respiratory Medicine, Department of Medicine, Division of Allergy and Clinical Immunology

October 1990 - June 1996
Assistant Faculty Member, National Jewish Center for Immunology and Respiratory Medicine, Department of Pediatrics, Division of Basic Sciences

October 1990 - June 1999
Adjunct Assistant Professor, University of Colorado Denver, Department of Biochemistry and Molecular Genetics

Relevant Publications

  1. Reusch J.E., D.J. Klemm. 2002. Inhibition of cAMP-Response Element-Binding Protein Activity Decreases Protein Kinase B/Akt Expression in 3T3-L1 Adipocytes and Induces Apoptosis. Journal of Biological Chemistry. 277:1426-1432.
  2. Watson P.A., A. Nesterova, C.F. Burant, D.J. Klemm, J.E. Reusch. 2001. Diabetes-Related Changes in cAMP Response Element-Binding Protein Content Enhance Smooth Muscle Cell Proliferation and Migration. Journal of Biological Chemistry. 276:46142-46150.
  3. Klemm D.J., P.A. Watson, M.G.Frid, E.C. Dempsey, J. Schaack, L.A. Colton, A. Nesterova, K.R. Stenmark, J.E. Reusch. 2001. cAMP Response Element-Binding Protein Content is a Molecular Determinant of Smooth Muscle Cell Proliferation and Migration. Journal of Biological Chemistry. 276:46132-46141.
  4. Klemm D.J., J.W. Leitner, P. Watson, A. Nesterova, J.E. Reusch, M.L. Goalstone, B. Draznin. 2001. Insulin-Induced Adipocyte Differentiation. Activation of CREB Rescues Adipogenesis from the Arrest Caused by Inhibition of Prenylation. Journal of Biological Chemistry. 276:28430-28435.
  5. Strickland, I., K. Kisich, P. J. Hauk, A. Vottero, G. P. Chrousos, D. J. Klemm, and D.Y.M. Leung. 2001. High Constitutive Glucocorticoid Receptor ß in Human Neutrophils Enables Them to Reduce Their Spontaneous Rate of Cell Death in Response to Corticosteroids. Journal of Experimental Medicine 193: 585-594.
  6. Routes, J.M., L.A. Colton, S. Ryan, and D.J. Klemm. 2000. CREB and C/EBP a are Required for the "Superstimulation" of PEPCK Gene Transcription by Adenoviral E1a and Cyclic-AMP. Biochemical Journal 352pt2:335-342.
  7. Reusch, J.E.-B., L.A. Colton, and D.J. Klemm. 1999. CREB Activation Induces Adipogenesis in NIH 3T3-L1 Cells. Molecular and Cellular Biology 20:1008-1020.
  8. Reusch, J.E.-B., and D.J. Klemm. 1999. Fat Cell Differentiation and Nutrition. Endocrine Journal. 140:2935-2937.
  9. Klemm, D.J., W.J. Roesler, L.A. Colton, K. Felder, and J. E.-B. Reusch. 1998. Insulin Stimulates CREB Phosphorylation and Transcriptional Transactivation Activity Through the MAP Kinase Pathway. Journal of Biological Chemistry 273:917-923.
  10. Leung, D.Y.M., Q. Hamid, A. Vottero, S.J. Szefler, W. Surs, E. Minshall, G.P. Chrousos, and D.J. Klemm. 1997. Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor b. Journal of Experimental Medicine 186:1567-1574.
  11. Klemm, D.J., L.A. Colton, S. Ryan, and J.M. Routes. 1996. Adenovirus E1A Proteins Regulate Phosphoenolpyruvate Carboxykinase Gene Transcription Through Multiple Mechanisms. Journal of Biological Chemistry 271:8082-8088.
  12. Routes, J.M., H. Li, S.T. Bayley, S. Ryan, and D.J. Klemm. 1996. E1A-p300 Binding Blocks Interferon’s Induction of Cytolytic Resistance to NK Cell Lysis and Interferon-Stimulated Gene Expression. Journal of Immunology 156:1055-1061.
  13. Rosenwasser, L.J., D.J. Klemm, J.K. Dresback, H. Inamura, J.J. Mascali, M. Klinnert, and L. Borish. 1995. Promoter Polymorphisms in the Chromosome 5 Gene Cluster in Asthma and Atopy. Clinical and Experimental Allergy 25:74-78.
  14. Roesler, W.J., J.G. Graham, R. Kolen, D.J. Klemm, and P.J. McFie. 1995. CREB Synergizes with Other Transcription Factors to Mediate cAMP Responsiveness. J. Biol. Chem. 270:8225-8232.
  15. Wheat, W.H., W.J. Roesler, and D.J. Klemm. 1994. Simian Virus 40 Small Tumor Antigen Inhibits the Dephosphorylation of Protein Kinase A-Phosphorylated CREB and Regulates CREB Transcriptional Stimulation. Molecular and Cellular Biology 14:5881-5890.
  16. Reusch, J.E., P. Hsieh, D.J. Klemm, J. Hoeffler, and B. Draznin. 1993. Insulin Inhibits Dephosphorylation of Adenosine 3',5'-Monophosphate Response Element-Binding Protein/Activating Transcription Factor-1: Effect on Nuclear Phosphoserine Phosphatase-2a. Endocrinology 135:2418-2422.
  17. Wadzinski, B.E., W.H. Wheat, L.F. Peruski, S. Jaspers, G.L. Johnson, and D.J. Klemm. 1993. Nuclear Protein Phosphatase 2A Inhibits Transcriptional Stimulation by PKA-Phosphorylated CREB. Molecular and Cellular Biology 13:2822-2834.
  18. Bhandari, B., W. J. Roesler, K.D. DeLisio, D. J. Klemm, N.S. Ross, and R.E. Miller. 1991. A Functional Promoter Flanks an Intronless Glutamine Synthetase Gene. Journal of Biological Chemistry. 266: 7784-7792.
  19. Park, E. A., W. J. Roesler, J. Liu, D. J. Klemm, A. L. Gurney, J. D. Thatcher and R. W. Hanson. 1990. The Role of CAAT/Enhancer Binding Protein in the Transcriptional Regulation of the Gene for Phosphoenolpyruvate Carboxykinase (GTP). Molecular and Cellular Biology. 10:6264-6272, 1990.
  20. Klemm, D. J., W. J. Roesler, J. Liu, E. A. Park and R. W. Hanson. 1990. In vitro Analysis of Promoter Elements Regulating Transcription of the Phosphoenolpyruvate Carboxykinase (GTP) Gene. Molecular and Cellular Biology. 10: 480-485.
  21. Klemm, D. J. and L. L. Barton. 1989. Protoporphyrinogen Oxidation Coupled to Nitrite Reduction with Membranes from Desulfovibrio gigas. FEMS Microbiology Letters. 61: 61-64.
  22. Klemm, D. J. and L. Elias. 1988. Purification and Assay of a Phosphatidylglycerol-stimulated Protein Kinase from Murine Leukemic Cells and Its Pertubation in Response to IL-3 and PMA Treatment. Experimental Hematology 16: 855-860.
  23. Klemm, D. J., A. L. Kazim and L. Elias. 1988. Phosphatidylgylcerol-Modulated Protein Kinase Activity from Human Spleen: 1. Enzyme Purification and Properties. Archives of Biochemistry and Biophysics. 265: 496-505.
  24. Klemm, D. J. and L. Elias. 1988. Phosphatidylglycerol-Modulated Protein Kinase Activity from Human Spleen: 2. Interaction with Phospholipid Vescicles. Archives of Biochemistry and Biophysics. 265: 506-513.
  25. Klemm, D. J. and L. Elias. 1987. A Distinctive Phospholipid-Stimulated Protein Kinase of Normal and Malignant Murine Hemopoeitic Cells. Journal of Biological Chemistry. 262: 7580-7595.
  26. Klemm, D. J. and L. L. Barton. 1987. Purification and Properties of Protoporphyrinogen Oxidase from an Anaerobic Bacterium, Desulfovibrio gigas. Journal of Bacteriology. 169: 5209-5215.
  27. Klemm, D. J. and L. Elias. 1986. Manganese-Phospholipid-Stimulated Protein Kinase as an Agent of Growth Factor Signal Transduction in Hematopoetic Cells. Blood. 68: 168a.
  28. Klemm, D. J. and L. L. Barton. 1985. Oxidation of Protoporphyriongen in the Obligate Anaerobe, Desulfovibrio gigas. Journal of Bacteriology. 164: 316-320.
  29. Rodrigues, R. K., D. J. Klemm and L. L. Barton. 1984. Iron Metabolism by an Ectomycorrhizal Fungus, Cenococcum graniforme. Journal of Plant Nutrition, 7: 459-468.
  30. Barton, L. L., H. C. Krivan and D. J. Klemm. 1982. A Specific Transport System for Fe2+ in Bacteria. Journal of Plant Nutrition. 5: 405-411.