Faculty


Ivan McMurtry, Ph.D.
Professor of Medicine

EDUCATION/TRAINING

Univ of Wyoming, Laramie WY
1965B.S.Zoology

Univ of Nebraska, Lincoln, NE
1968M.S.Physiology

Colorado State University, Ft. Collins, CO
1972Ph.D.Physiology
UCD
4200 E. Ninth Ave.
Denver, CO 80262
Tel: 303.315.4476
Ivan.McMurty@uchsc.edu

PROFESSIONAL EXPERIENCE

1968 - 1971
Graduate Research Assistant, Physiology & Biophysics, CSU

1971 - 1973
Research Associate, Pathology, CSU

1973 - 1976
Postdoctoral Research Fellow, CVP Research Lab, UCD

1976 - 1979
Instructor, Department of Medicine, UCD

1979 - 1983
Assistant Professor of Medicine, UCD

1983 - 1993
Associate Professor, Department of Medicine, UCD

1993 - Present
Professor, Department of Medicine, UCD

1982 - Present
Faculty Affiliate, Dept. Physiology, CSU

1998 –Present
Director, Cardiovascular Pulmonary Research – UCD

SELECTED PUBLICATIONS

  1. McMurtry IF. Angiotensin is not required for hypoxic constriction in salt solution-perfused rat lungs. J Appl Physiol 56:375-380, 1984.
  2. Stanbrook HS, Morris KG, McMurtry IF. Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists. Am Rev Resp Dis 130:81-85, 1984.
  3. Herget J, McMurtry IF. Effects of ouabain, low K+, and aldosterone on hypoxic pressor reactivity of rat lungs. Am J Physiol 248:H55-H60, 1985.
  4. McMurtry, IF. BAY K 8644 potentiates and A23187 inhibits hypoxic vasoconstriction in rat lungs. Am J Physiol 249:H741-H746, 1985.
  5. Gillespie MN, Owasoyo JO, McMurtry IF., O’Brien RF. Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture. J Pharmocol Exp Ther 236:339-343, 1986.
  6. McMurtry IF, Morris KG. Platelet-activating factor causes pulmonary vasodilation in the rat. Am Rev Resp Dis 134:757-762, 1986.
  7. O’Brien RF, Robbins RJ, McMurtry IF. Endothelial cells in culture produce a vasoconstrictor substance. J Cell Physiol 132:263-270, 1987.
  8. Herget J, McMurtry IF. Dexamethasone potentiates hypoxic vasoconstriction in salt solution-perfused rat lungs. Am J Physiol 253:H574-H581, 1987.
  9. Raffestin B, McMurtry IF. Intracellular alkalosis potentiates hypoxic vasoconstriction in salt solution-perfused rat lungs. J Appl Physiol 63:2524-2531, 1987.
  10. Yamaguchi T, Rodman D, O’Brien RF, McMurtry IF. Modulation of pulmonary artery contraction by endothelium-derived relaxing factor. Eur J Pharmacol 161:259-262, 1989.
  11. Rodman DM, Yamaguchi T, O’Brien RF, McMurtry IF. Hypoxic contraction of isolated rat pulmonary artery. J Pharmacol Exp Ther 248:952-959, 1989.
  12. Yamaguchi T, O’Brien RF, Hanson W, Wagner WW Jr, McMurtry IF. Prostacyclin contributes to inhibition of hypoxic pulmonary vasoconstriction by alkalosis. Prostaglandins 38:53-63, 1989.
  13. Orton, EC, Raffestin B, McMurtry IF. Protein kinase C influences rat pulmonary vascular reactivity. Am Rev Resp Dis 141:654-658, 1990.
  14. Rodman DM, Yamaguchi T, Hasunuma K, O’Brien RF, McMurtry IF. Effects of hypoxia on endothelium-dependent relaxation of rat pulmonary artery. Am J Physiol: Lung Cell Molec Physiol 258:L207-L214, 1990.
  15. Ashmore RC, O’Brien RD, Stelzner TJ, Dauber IM, Horwitz LD, McMurtry IF and VanBenthuysen KM. Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides. Biochem Biophys Res Commun 166:909-915, 1990.
  16. Westcott JY, Henson J, McMurtry IF, O’Brien RF. Uptake and metabolism of endothelin in the isolated perfused rat lung. Exp Lung Res 16:521-532, 1990.
  17. Hasunuma K, Rodman DM, O’Brien RF, McMurtry IF. Endothelin-1 causes pulmonary vasodilation in the rat. Am J Physiol: Heart Circ Physiol 259:H48-H54, 1990.
  18. Rodman DM, Hasunuma K, Peach JL, McMurtry IF. Inhibitor of ATP-sensitive K+ channel alters neither hypoxic contraction nor relaxation of rat aorta. Blood Vessels 27:365-368, 1990.
  19. Hasunuma K, Yamaguchi T, Rodman DM, O’Brien RF, McMurtry IF. Effects of inhibitors of EDRF and EDHF on the vasoreactivity of perfused rat lungs. Am J Physiol: Lung Cellular Molec Physiol 260:L97-L104, 1990.
  20. Rodman DM, Mallet J, McMurtry IF. Effects of inhibitors of energy metabolism on endothelium-dependent relaxation of rat pulmonary artery and aorta. Am J Resp Cell Molec Biol 4:237-242, 1990.
  21. Dempsey EC, McMurtry IF, O’Brien RF. Protein kinase C activation allows bovine pulmonary artery smooth muscle cells to proliferate in response to hypoxia. Am J Physiol: Lung Cell Molec Physiol 260:L136-L145, 1990.
  22. Abman SH, Chatfield BA, Hall SL, McMurtry IF. Role of endothelium-derived relaxing factor during the transition of the pulmonary circulation at birth. Am J Physiol: Heart Circ Physiol 259:H1921-H1927, 1990.
  23. Abman SH, Chatfield BA, Rodman DM, Hall SL, McMurtry IF. Maturational changes in endothelium-derived relaxing factor activity of bovine pulmonary arteries in vitro. Am J Lung Cell Molec Physiol 260:L280-L285, 1990.
  24. Ashmore RC, Rodman DM, Sato K, Webb SA, O’Brien RF, McMurtry IF., Stelzner TJ. Paradoxical constriction to platelets by arteries from rats with pulmonary hypertension. Am J Physiol: Heart Circ Physiol 260:H1929-H1934, 1991.
  25. Hasunuma K, Rodman DM, McMurtry IF. Effects of K+channel blockers on vascular tone in the perfused rat lung. Am Rev Resp Dis 144:884-887, 1991.
  26. Sheridan FM, Horwitz LD, McMurtry IF. Effects of phorbol esters on canine coronary artery constriction and dilation in vitro. Am J Physiol: Heart Circ Physiol 261:H236-H242, 1991.
  27. Sheridan FM, Dauber IM, McMurtry IF, Lesnefsky EJ, Horwitz LD. Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion. Circ Res 69:1566-1574, 1991.
  28. Sato K, Webb SA, Tucker A, Rabinovitch M, O’Brien RF, McMurtry IF, Stelzner TJ. Factors influencing the idiopathic development of pulmonary hypertension in the fawn hood rat. Am Rev Resp Dis 145:793-797, 1992.
  29. Rodman DM, Stelzner TJ, Zamora MR, Bonvallet ST, Oka M, Sato K, O’Brien RF, McMurtry IF. Endothelin-1 increases pulmonary microvascular pressure and causes pulmonary edema in salt solution - but not blood-perfused rat lungs. J Cardiovasc Pharmacol 20:658-663, 1992.
  30. Oka M, Hasunuma K, Webb SA, Stelzner TJ, Rodman DM, McMurtry IF. Endothelium-derived relaxing factor suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs. Am J Physiol: Lung Cell Molec Physiol 264:L587-L597, 1993.
  31. Oka M, Morris KG, McMurtry IF. NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension. J Appl Physiol 75:1075-1080, 1993.
  32. Bonvallet ST, Oka M, Yano M, Zamora MR, McMurtry IF, Stelzner TJ. BQ123, an ETA receptor antagonist, attenuates endothelin-1-induced vasoconstriction in rat pulmonary circulation. J Cardiovasc Pharmacol 22:39-43, 1993.
  33. Stevens T, Cornfield DN, McMurtry IF, Rodman DM. Acute reductions in PO2 depolarize pulmonary artery endothelial cells and decrease [CA2+]i. Am J Physiol: Heart Circ Physiol 266:H1416-H1421, 1994.
  34. McQueston JA, Kinsella JP, Ivy DD, McMurtry IF, Abman SH. Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation. Am J Physiol: Heart Circ Physiol 268:H288-H294, 1995.
  35. Stevens T, Nakahashi Y, Cornfield D, McMurtry IF, Cooper DMF, Rodman DM. Calcium-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function. Proc Natl Acad Sci 92: 2696-2700, 1995.
  36. Cohen AH, Hanson K, Morris K, Fouty B, McMurtry IF, Clarke W, Rodman DM. Inhibition of cGMP specific phos-phodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats. J Clin Invest 97:172-179, 1996.
  37. Muramatsu M, Tyler RC, Rodman DM, McMurtry IF. Thapsigargin stimulates increased NO activity in hypoxic hypertensive rat lungs and pulmonary arteries. J Appl Physiol 80: 1336-1344, 1996.
  38. Chetham PM, Sefton WD, Bridges JP, Stevens T, McMurtry IF. Inhaled NO pretreatment but not post-treatment attenuates I/R-induced pulmonary microvascular leak. Anethesiology 86: 895-902, 1997.
  39. Muramatsu M, Rodman DM, Oka M, McMurtry IF. Endothelin-1 mediates nitro-L-arginine vasoconstriction of hypertensive rat lungs. AJP: Lung Cell Molec Physiol 272: L807-L812, 1997.
  40. Muramatsu M, Tyler RC, Rodman DM, McMurtry IF. Possible role of T-type Ca++ channels in L-NNA vasoconstriction of hypertensive rat lungs. AJP: Heart Circ Physiol 272: H2616-H2621, 1997.
  41. Muramatsu M, Tyler RC, Gutkowska J, Klinger JR, Hill NS, Rodman DM, McMurtry IF. Atrial natriuretic peptide accounts for increased cGMP in hypoxia-induced hypertensive rat lungs. AJP: Lung Cell Molec Physiol 272: L1126-L1132, 1997.
  42. Fouty B, Komalavilas P, Muramatsu M, Cohen A, McMurtry IF, Lincoln TM, Rodman DM. Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation. AJP: Heart Circ Physiol 274: H672-H678, 1998.
  43. Le Cras TD, Tyler RC, Horan MP, Morris KG, Tuder RM, McMurtry IF, Johns RA, Abman SH. Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung.J Clin Invest 101: 795-801, 1998.
  44. Tyler RC, Muramatsu M, Abman SH, Stelzner TJ, Rodman DM, Bloch KD, McMurtry IF. Variable expression of NO synthase in three forms of rat pulmonary hypertension. AJP: Lung Cell Molec Physiol 276:L297-L303, 1999.
  45. Fagan KA, Fouty BW, Tyler RC, Morris KG, Hepler LK, Sato K, LeCras TD, Abman SH, Weinberger HD, Huang PL, McMurtry, IF, Rodman, DM. The pulmonary circulation of homozygous or heterozygous eNOS null mice is hyperresponsive to mild hypoxia. J Clin Invest 103: 291-299, 1999.
  46. Sato,K. Rodman DM, McMurtry IF. Hypoxia inhibits increased ETB receptor-mediated NO synthesis in hypertensive rat lungs. AJP: Lung Cell Molec Physiol 276: L571-L581, 1999.
  47. Fagan KA, Tyler RG, Sato K, Fouty BW, Morris KG, Huang PL McMurtry IF, Rodman DM. Relative contribution of endothelial, inducible and neuronal NOS to tone in the murine pulmonary circulation. AJP: Lung Cell Molec Physiolo 277: L472-L478, 1999.
  48. Li KX, Fouty BW, McMurtry IF, Rodman DM. Enhanced ETA-receptor-mediated inhibition of Kv channels in hypoxic hypertensive rat pulmonary artery myocytes. AJP: Heart Circ Physiol 277: H363-H370, 1999.
  49. Sato, K. Morio Y, Morris KG, Rodman DM, McMurtry IF. Mechanism of hypoxic pulmonary vasoconstriction involves ETA receptor-mediated inhibition of KATP channel. AJP: Lung Cell Molec Physiol: 278:L434-L442, 2000.
  50. LeCras TD, Markham NE, Morris KG, Ahrens CR, McMurtry IF, Abman SH. Neonatal dexamethasone treatment increases the risk for pulmonary hypertension in adult rats. AJP: Lung Cell Molec Physiol, 278: L822-L829, 2000.
  51. Carter E. Sato K, Morio Y, McMurtry IF. Inhibition of Kca channels restores blunted hypoxic pulmonary vasoconstriction in rats with cirrhosis. AJP: Lung Cell Molec Physiol 279: L903-L910, 2000.
  52. Ivy DD, McMurtry IF, Yangagisawa M, Gariepy CE, Morris KG, LeCras TD, Abman SH. Enhanced acute hypoxic pulmonary vasoconstriction in endothelin B receptor deficient rats. AJP: Lung Cell Molec Physiol, in press, 2001.