Faculty


Mark R. Nicolls, M.D.
Assistant Professor of Medicine

EDUCATION/TRAINING

University of Portland
1982-1987B.S.Biology

Stanford University School of Medicine
1988-1993M.D.

Stanford University Hospital
1993-1996Intern/Resident

University of Colorado Denver
1996-1999FellowPulmonary/Critical Care
UCD
4200 E. Ninth Ave.
Denver, CO 80262
Tel: 303.315.5056/5309
Mark.Nicolls@uchsc.edu

PROFESSIONAL EXPERIENCE

7/99-6/00
Instructor, University of Colorado Denver

7/00-
Assistant Professor, University of Colorado Denver

7/00-
Associate Director, Human Islet Transplantation Program

11/01-
Associate Director, Section of Transplantation Immunology

SELECTED PEER-REVIEWED PUBLICATIONS

  1. Nicolls MR, Coulombe M, Diamond A, Bolwerk A, Beilke J, Gill RG. The conditional requirement of IFNg for islet allograft survival. (manuscript submitted to J Immunol).
  2. Nicolls MR, Coulombe M, Beilke J, Gill RG. Dominant transplantation tolerance induced by simultaneous perturbation of LFA-1 (CD11a) and CD154 pathways (manuscript submitted to PNAS).
  3. Nicolls MR, Coulombe M, Gill RG. The basis of immunogenicity of endocrine allografts. Crit Rev Immunol 2001; 21:87-101.
  4. Tran GT, Carter N, He XY, Spicer TS, Plain KM, Nicolls M, Hall BM. Hodgkinson SJ. Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on T(h)1 cells that is augmented by IL-4. Int Immunol 2001; 13:1109-1120.
  5. Nicolls MR, Coulombe M, Bolwerk A, Gill RG. Anti-LFA-1-induced allograft prolongation does not require IL-4 or IFNg. J Immunol. 2000 164:3627-3634.
  7. Nicolls MR, Weiss S, Schwarz MI. Diffuse Panbronchiolitis. Infect. Med. 1998; 15(9):657-662.
  8. Nicolls MR, Terada LS, Tuder RM, Prindiville SA, Schwarz MI. Diffuse alveolar hemorrhage with underlying pulmonary capillaritis in the retinoic acid syndrome. Am J Respir Crit Care Med 1998; 158(4):1302-1305.
  9. Nicolls MR, Newman LS. Berylliosis: diagnosis and management. UPTODATE in Pulmonary and Critical Care Medicine. American Thoracic Society. CD ROM computer program, 1997.
  10. Nicolls MR, Wanger J, Irvin CG. Bronchodilator response in the ‘Borderlands’. Respir Care 1997; 42(2):230-232.
  11. Woodley SL, Gurley KE, Hoffman SL, Nicolls MR, Hagberg R, Clayberger C, Holm B, Wang X, Hall BM, Strober S. Induction of tolerance to heart allografts in rats using posttransplant total lymphoid irradiation and anti-T cell antibodies. Transplantation 1993; 56:1443-1447.
  12. Nicolls M, Aversa G, Pearce N, Spinelli A, Berger M, Gurley K, Hall B. Induction of long term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody. Transplantation 1993; 55:459-468.
  13. Campbell R, Nicolls M, McGrath K, Norton-Reel D. Acute renal failure: the spermine determinant. In: Geographical Nephrology: Proceedings of the International Symposium on Geographical Nephrology, M Mochizuki, N Sujino, V Sitprija (Eds) 1990; 22-46.

ABSTRACTS

  1. Wiseman AC, Nicolls MR, Diamond AS, Beilke J, Gill RG. . The contribution of IFN-g to islet allograft survival following anti-CD4 therapy. Cell Transplantation 2001;10: 523.
  2. Nicolls MR, Coulombe M, Beilke J, Gill RG A strategic combination of anti-LFA-1 and anti-CD40L monoclonal antibody therapy induces dominant tolerance in experimental islet transplantation. Cell Transplantation 2001;10: 527.
  3. Nicolls MR, Coulombe M, Beilke J, Gill RG. A non-depleting combination of anti-LFA-1 and anti-CD154 therapy is effective in high-responder recipients. Am J Transplant 2001; 1: 933A.
  4. Wiseman AC, Nicolls MR, Diamond AS, Beilke J, Gill RG. The contribution of IFN-g to islet allograft survival following anti-CD4 therapy. Am J Transplant 2001; 1: 11A.
  5. Coulombe M, Nicolls MR, Gill RG. Anti-LFA-1 induced islet allograft survival does not require STAT6. Am J Transplant 2001; 1: 1203A
  6. Wiseman A, Nicolls M, Diamond A, Gill R. Anti-CD4 therapy requires an intact IFN-g axis to prolong islet allograft survival. International Society of Nephrology Forefronts in Nephrology Symposium. Beaver Creek, CO. 2000.
  7. Nicolls MR Coulombe M, Bolwerk A, Beilke J, Gill RG. IFN-g is not a universal requirement for allograft survival. Transplantation 2000; 69:715A.
  8. Coulombe M, Nicolls MR, Beilke J, Gill RG. Efficacy of allograft tolerance induced by anti-LFA-1 maps to non-MHC genes. Transplantation 2000; 69:997A.
  9. Zamora MR, Torres F, Nicolls MR, Hodges T. Preemptive therapy of cytomegalovirus dnaemia decreases cytomegalovirus-associated acute rejection and possibly chronic rejection following lung transplantation. Transplantation 2000; 69:108A
  10. Coulombe M, Nicolls MR, Diamond AS, Gill RG. Disparate requirements for IFNg in experimental islet allograft prolongation induced by anti-LFA-1 and anti-CD4 therapy. Transplantation Society Basic Sciences Symposium, 1999.
  11. Nicolls MR, Coulombe M, Bolwerk A, Gill RG. IFNg and IL-4 are not required for anti-LFA-1 induced islet allograft prolongation. Transplantation 1999; 67:115.
  12. Coulombe M, Yang H, Nicolls M, Bolwerk A, Araujo R, Gill R. Transferable allograft tolerance induced by anti-LFA-1 (CD11a) therapy. Transplantation 1999; 65:486A.
  13. Campbell R, Jamdar S, Keniston R, McGrath K, Nguyen P, Matthews J, Nicolls M, Norton Reel DJ. Clinical Res 1992; 40: A112.
  14. Quiza C, Gurley KE, Spinelli A, Leenhaerts P, Nicolls M, Hall BM. Role of T cells in Heymann Nephritis. Clinical Res 1991; 39: A340.
  15. Nicolls MR, Aversa GA, Pearce NW, Spinelli A, Berger MF, Gurley KE, Hall BM. Anti-CD3 monoclonal antibody induces tolerance to alloantigens in rats. Clinical Res 1991; 39:A380.
  16. Nicolls MR, Aversa GA, Hall BM. Panel of monoclonal antibodies directed against rat T-lymphocytes. Clinical Res 1990; 38:A215.
  17. Austin S, Movahed L, Nicolls M, Pearce N, Gurley K, Spinelli A, Martens C, Hall BM. Profiles of cytokine gene expression in a model of specific tolerance induced by anti-CD3 mAb. Transplantation Society Second Basic Sciences Symposium, 1991.
  18. Campbell R, Jamdar S, Keniston A, McGrath K, Nguyen P, Matthews J, Nicolls M, Norton-Reel DJ. Rethinking multiple organ failure: the polyamine paradigm. Ninth Congress of the International Pediatric Nephrology Association, 1992.
  19. Campbell R, Norton-Reel D, Brown R, Nicolls M, Naylor B, Rudine M. Dynamic changes in pars 3 cells approaching loop on Henle junction. Ped Res 1990; 27:324A.
  20. Campbell R, Norton-Reel D, Nicolls M, Nhoung S, Naylor B. Pars 3 secretory processes in the mouse. Kidney Int 1990; 37:224.
  21. Campbell R, Nicolls M, Nhoung S, Williamson S, Russi J, McGrath K. Subcellular events inspermine induced acute tubulonecrosis. Kidney Int 1989; 35:403.
  22. Campbell R, Norton D, Nhoung S, Nicolls M. Unique morphology of pars 3: effects of endogenous polycations. Ped Res 1989; 25:336A.
  23. Campbell R, Norton D, Nhoung S, Nicolls M. Unique morphological features of normal pars 3 cells and the effects of endogenous cations. Clin Res 1989; 37:111A.
  24. Campbell R, Nhoung S, Nicolls M, Russi J, Rudine M, Naylor B. Acute tubular necrosis induced by natural polycations. Clin Res 1988; 36:245A.