Faculty


Richard T. Sawyer, Ph.D.
Assistant Professor of Medicine

EDUCATION/TRAINING

Colorado State University, Fort Collins, CO
1972B.S.Biological Science

Eastern Michigan University, Ypsilanti, MI
1974M.S.Biological Science

Michigan State University, E. Lansing, MI
1978Ph.D.Botany & Plant Pathology
UCD
4200 E. Ninth Ave.
Denver, CO 80262
Tel: 303.315.7047
sawyerr@njc.org

PROFESSIONAL EXPERIENCE

1978-
Research Associate and Instructor, East Carolina University School of Medicine, Department of Pathology and Laboratory Medicine, Greenville, North Carolina

1980-
Research Scientist IV, Norwich Eaton Pharmaceuticals, Norwich, New York

1982-
Assistant Professor of Microbiology and Immunology, Mercer University School of Medicine, Macon, Georgia

1986-
Associate Professor of Microbiology and Immunology, Mercer University School of Medicine, Macon, Georgia

1987-
Associate Member, Trudeau Institute, Inc., Saranac Lake, New York

1989-
Associate Professor of Microbiology and Immunology, Mercer University School of Medicine, Macon, Georgia

1992-
Research Associate, Division of Basic Immunology, National Jewish Medical and Research Center, Denver, Colorado

1996-
Research Associate, Department of Medicine, Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, Colorado

1998-
Assistant Faculty Member, Department of Medicine, Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, Colorado.

PUBLICATIONS

  1. Sawyer RT, Deskins DC, Volz PA. Phosphoglycerides of Trichophyton terrestre and one phenotype selected from the Apollo 16 microbial ecology evaluation device. Appl Microbiol 1975; 29:658-662.
  2. Scott RM, Sawyer RT. Detection of steroids with molybdovanadophosphoric acids on thin-layer chromatograms. Microchem J 1975; 20:309-312.
  3. Sawyer RT, Moon RJ, Beneke ES. Hepatic clearance of Candida albicans in rats. Infect Immun 1976; 14:1349-1355.
  4. Sawyer RT, Moon RJ, Beneke ES. Trapping and killing of Candida albicans by Corynebacterium parvum activated livers. Infect Immun 1981; 32:945-950.
  5. Sawyer RT, Strausbauch PA, Volkman A. Resident macrophage proliferation in mice depleted of blood monocytes by strontium-89. Lab Invest 1982; 46:165-170.
  6. Strausbauch PA, Sawyer RT, Volkman A. Ultrastructure of beige mouse peritoneal macrophage lysosomes. J RES 1982; 31:361-365.
  7. Sawyer RT. The significance of resident pulmonary alveolar macrophage proliferation to population renewal. J Leukoc Biol 1986; 39:77-87.
  8. Sawyer RT. The cytokinetic behavior of pulmonary alveolar macrophages in monocytopenic mice. J Leukoc Biol 1986; 39:89-99.
  9. Sawyer RT. The ontogeny of pulmonary alveolar macrophages in parabiotic mice. J Leukoc Biol 1986; 40:347-354.
  10. Sawyer RT. The effect of monosaccharides on in situ trapping of Candida albicans. Mycopath 1988; 104:81-85.
  11. Sawyer RT, Harmsen AG. The relative contribution of resident pulmonary alveolar macrophage and inflammatory polymorphonuclear neutrophils in host resistance to pulmonary infection by Candida albicans. Mycopath 1989; 108:95-105.
  12. Sawyer RT. Experimental pulmonary candidiasis. Mycopath 1990; 109:99-109.
  13. Sawyer RT, Horst MN, Garner RE, Hudson JA, Jenkins PR, Richardson AL. Altered hepatic clearance and killing of Candida albicans in the perfused mouse liver. Infect Immun 1990; 58:2869-2874.
  14. Sawyer RT, Garner RE, Hudson JA. Arg-Gly-Asp (RGD) peptides alter killing of Candida albicans in the isolated perfused mouse liver. Infect Immun 1992; 60:213-218.
  15. Sawyer RT, Garner RE, Hudson JA. Effect of lectins on the hepatic clearance and killing of Candida albicans in the isolated perfused mouse liver. Infect Immun 1992; 60:1041-1046.
  16. Sawyer RT. Intravenous zymosan-A induces an alveolar inflammatory response. Inflammation 1993; 17:273-281.
  17. Garner RE, Rubanowice K, Sawyer RT, Hudson JA. Secretion of TNF-a by alveolar macrophages in response to Candida albicans mannan. J Leukoc Biol 1994; 55:161-168.
  18. Drevets DA, Sawyer RT, Potter TA, Campbell PA. Listeria monocytogenes infects human endothelial cells by two distinct mechanisms. Infect Immun 1996; 63:4268-4276.
  19. Sawyer RT, Drevets DA, Campbell PA, Potter TA. Internalin A can mediate phagocytosis of Listeria monocytogenes by mouse macrophage cell lines. J Leukoc Biol 1996; 60:603-610.
  20. Sawyer RT, DA Doherty, BA Schumacher, LS Newman. Beryllium-stimulated in vitro migration of peripheral blood lymphocytes. Toxicology 1999;138:1555-163.
  21. Sawyer RT, LA Kittle, H Hamada, LS Newman. Beryllium-stimulated production of tumor necrosis factor-a by a mouse hybrid macrophage cell line. Toxicology 2000; 143:235-247.
  22. Hamada H, RT Sawyer, LA Kittle, LS Newman. Beryllium-stimulation does not activate transcription factors in a mouse hybrid macrophage cell line. Toxicology 2000;143:249-261.
  23. Bauer, RA, RT Sawyer, E Daniloff, R Balkissoon, CS Rose, LS Newman. Bronchoalveolar lavage macrophage-lymphocyte clusters in granulomatous disease are linked to lymphocytosis. Sarcoidosis, Vasculitis and Diffuse Lung Diseases. 2000;17:174-180.
  24. Sawyer RT, VA Fadok, LA Kittle, LS Newman. Beryllium-induced apoptosis in macrophage cell lines. Toxicology 2000;149:129-142.
  25. Maier, L.A., L.A. Kittle, R.T. Sawyer, and L.S. Newman. IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. Eur Resp J 2001; 17:403-415.
  26. Maier LA, Sawyer RT, Bauer RA, Kittle LA, Lympany P, McGrath D, duBois R, Daniloff E, Rose CS, Newman LS. Beryllium-stimulated TNF-a is associated with the –308 TNF-a promoter polymorphism and with clinical severity in chronic beryllium disease. Am J Respir Crit Care Med 2001; (in press).

BOOKS

  1. Sawyer RT, A Volkman. Evaluation of monocyte distribution and traffic. In: H.B. Herskowitz et al. (eds), Manual of Macrophage Methodology, New York: Marcel Dekker Inc. 1981; 459-469.
  2. Volkman A, RT Sawyer. Systemic labeling of mononuclear phagocytes. In: DO Adams et al. (eds), Methods for Studying Mononuclear Phagocytes, New York: Academic Press 1981; 969-981.
  3. Sawyer RT. Cytokinetics of resident pulmonary alveolar macrophages in splenectomized-monocytopenic mice. In: JJ Oppenheim and DM Jacobs (eds), Leukocytes and Host Defense, New York: AR Liss Pub Co 1986; 307-312.
  4. Vourlekis JA, RT Sawyer, LS Newman. Sarcoidosis: Developments in etiology, immunology, and therapeutics. Adv Intern Med 2000; 45:209-257.
  5. Sawyer RT, Maier LA, Kittle LA, Newman LS. Chronic beryllium disease: A model interaction between innate and acquired immunity. Internatl Immunopharmacol 2001; (in press).