Faculty


Laimute Taraseviciene-Stewart, Ph.D.
Instructor of Medicine

EDUCATION/TRAINING

Vilnius University, Lithuania
1971 B.S. Biochemistry

Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, Kiev, Ukraine
1977 Ph.D. Molecular Biology

Institute of Biochemistry, Lithuanian Scientific Council, Vilnius, Lithuania
1993 Ph.D. Molecular Biology


UCD
4200 E. Ninth Ave.
Denver, CO 80262
Tel: 303.315.1352
laimute.taraseviciene@uchsc.edu

PROFESSIONAL EXPERIENCE

2001-present
Instructor, Pulmonary Division Department of Medicine, University of Colorado School of Medicine, Denver, CO

1995-2001
Research Associate, Department of Pathology, University of Colorado School of Medicine, Denver, CO

1994-1995
Research Associate, Department of Pathology, University of Colorado School of Medicine, Denver, CO

1991-1994
Visiting Scientist, Department of Microbiology, University of Umea, S 901 87 Umea, Sweden

1989-1991
Research Associate, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO

1975-1999
Research Scientist, Institute of Biochemistry, Vilnius, Lithuania

SELECTED PUBLICATIONS

  1. Taraseviciene L., Bjork G.R., Uhlin B.E. Evidence for an RNA binding domain in the Escherichia coli processing endoribonuclease RNase E. J. Biol. Chem., 44:26391-26398, 1995..
  2. Vezeliene D., Taraseviciene L., Ivanov L.L., Jasaitis A., Lukosevicius L. The effects of myocardial ischemia on the aggregate state of rabbit liver aminoacyl-tRNA synthetases and tRNA methyltransferases. Biopolimery I Kletka (Kiev) 11:66-72. 1995
  3. L. Taraseviciene A half-decade of Ribonuclease E Research Proceedings of the Institute of Biochemistry,Vilnius (1996), p. 25-28
  4. S. K. Nordeen, C.A. Ogden, L. Taraseviciene, B.A. Lieberman Extreme position dependence of a canonical hormone response element Abstracts, 79th Annual Meeting of The Endocrine Society, , June 11-14, 1997,Minneapolis, MN, Abstract P3-459
  5. V. Boonvaratanakorkit, V. Melvin, P.Prendergast, E. Allegretto, E.M. Wilson, L. Taraseviciene, S.K. Nordeen, and D.P. Edwards HMG-1 protein facilitates DNA binding and transcriptional activation of the steroid hormone group of intracellular recptors Abstracts, 79th Annual Meeting of The Endocrine Society, , June 11-14, 1997, Minneapolis, MN, Abstract P3-453
  6. S. K. Nordeen, C.A. Ogden, L. Taraseviciene, B.A. Lieberman Extreme position dependence of a canonical hormone response element Mol. Endocrinology, 12:891-898, (1998)
  7. V. Boonvaratanakorkit, V. Melvin, P.Prendergast, E. Allegretto, E.M. Wilson, L. Taraseviciene, S.K. Nordeen, and D.P. Edwards High Mobility Group Chromatin Proteins-1 and -2 Functionally Interact with Steroid Hormone Receptors to Enhance Their DNA Binding in Vitro and Transcriptional Activity in Mammalian Cells Molecular and Cellular Biology, 18:4471-4487, (1998)
  8. Tuder, R. M., Tarasevicience, L., Hirth, P., Voelkel, N. F. Inhibition of the VEGF receptor causes severe pulmonary hypertension (PAH) in rats. Circulation 100, I-241, 1999
  9. Y. Kasahara, L. Taraseviciene, P. Hirth, N. Voelkel, R. M. Tuder Severe pulmonary hypertension (PH) caused by VEGF receptor KDR blockade with SU5416 in rats: a model for severe PH in humans. Abstracts from ATS Meeting, Toronto, Canada, 2000
  10. L. Taraseviciene, Y. Kasahara, L. Alger P. Hirth*, N. Voelkel, R. M. Tuder Inhibition of VEGF receptor KDR at hypoxic conditions causes a severe pulmonary hypertesion (PH) in rats: a model for severe PH in humans. Abstracts, Keystone Symposia “Experimental and clinical regulation of Angiogenesis (D2), Abstract 236, March 2-7, 2000
  11. R. M. Tuder, L. Taraseviciene-Stewart, J. Stewart, L. Gera, P. Hirth, N. Voelkel Caspase inhibitor Z-Asp and Bradykinin antagonist B9430 block intravascular pulmonary endothelial proliferation and severe pulmonary hypertension in chronically hypoxic rats treated with the VEGF receptor 2 inhibitor SU5416 Abstracts from the 73nd American Heart Association Meeting, Abstracts 1252, New Orleans, 2000
  12. R.M. Tuder, K. Wood, L. Taraseviciene, S.C. Flores, N.F. Voelkel Cigarette smoke extract decreases the expression of vascular endothelial growth factor by cultured cells and triggers apoptosis of pulmonary endothelial cells. Chest 2000 May; 117(5 Suppl 1): 241S-2S
  13. Y. Kasahara, R.M. Tuder, L. Taraseviciene-Stewart, T.D. Le Cras, S. Abman, P.K. Hirth, J. Waltenberger, N. Voelkel Inhibition of VEGF receptor causes lung cell apoptosis and emphysema. JCI 106:1-10, 2000
  14. L. Taraseviciene and S.K. Nordeen Ligand-Independent Activation of Human Progesterone Receptor but not Human Glucocorticoid Receptor: A Constitutive Nuclear Localization Signal Promotes Hormone-Independent Nuclear Translocation of Glucocorticoid Receptor Without Conferring Competence for Ligand-Independent Activation Submitted to publication
  15. L. Taraseviciene-Stewart, Y. Kasahara, L. Alger, P. Hirth, G. McMahon, J. Waltenberger, N.F. Voelkel, R.M. Tuder Inhibition of the VEGF Receptor-2 combined with Chronic Hypoxia Causes Cell Death-Dependent Pulmonary Endothelial cell Proliferation and Severe Pulmonary Hypertension. FASEB J, 15:427-438, 2001
  16. R.M. Tuder, M. Chacon, L. Alger, J. Wang, L. Taraseviciene-Stewart, Y. Kasahara, C. Cool, A.E. Bishop, M. Geraci, G.L. Semenza, M.Yacoub, J.M. Polak, N.F.Voelkel. Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. J Pathol 195: 367-374, 2001
  17. R.M. Tuder, C. Cool, M.Yeager, L. Taraseviciene-Stewart, T. Bull, N.F.Voelkel. The pathobiology of pulmonary hypertension. Clinics in Chest Medicine, 22: 405-418, 2001 L. Taraseviciene-Stewart, L. Gera, P. Hirth, N.F. Voelkel, R.M. Tuder, J.M. Stewart. A bradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in rat model. Can. J. Physiol. Pharmacol. In press
  18. Taraseviciene-Stewart L, Scerbavicius R, Choe KH, *Tuder RM, and Voelkel NF. Immunization with xenogeneic endothelial cellS cause emphysema in rats. Abstracts from ATS Meeting, Atlanta, Georgia, 2002
  19. Taraseviciene-Stewart L, Choe KH, Scerbavicius R, Cool C, Hirth P*, Tuder RM**, and Voelkel NF. Approaches to treatment of severe pulmonary hypertension induced by VEGF receptor blockade and chronic hypoxia. Abstracts from ATS Meeting, Atlanta, Georgia, 2002
  20. Choe KH, Taraseviciene-Stewart L, Scerbavicius R, Tuder RM*, Voelkel NF. Methylprednisolone Induces Alveolar Septal Cell Apoptosis and Emphysema In Adult Rats. Abstracts from ATS Meeting, Atlanta, Georgia, 2002
  21. R.M. Tuder, L. Taraseviciene-Stewart, S. Flores, D. Salvamini, N.F.Voelkel. Anti-Oxidants Prevent THE Development of Emphysema Induced by VEGF Receptor Blockade. Abstracts from ATS Meeting, Atlanta, Georgia, 2002
  22. J.M. Stewart, L. Taraseviciene-Stewart, P. *Hirth, N.F. Voelkel, R.M. **Tuder, L. Gera. Bradykinin antagonist B9430 Prevents severe pulmonary hypertension in a rat model. Abstracts from Kinin-2002 Meeting, Charleston, SC, 2002
  23. Taraseviciene-Stewart L, Choe KH, Scerbavicius R, Stewart J, Gera L, Hirth P, Tuder RM, and Voelkel NF. Approaches to therapy of severe pulmonary hypertension induced by VEGF receptor blockade and chronic hypoxia. Abstracts from Keystone Meeting “Angiogenesis in cancer and other diseases: from genes to function to therapy”, Banff, Canada, March 8-13, 2002
  24. John M. Stewart, Laimute Taraseviciene-Stewart, Lajos Gera, *Rubin M. Tuder and Norbert F. Voelkel. Vascular Endothelial Growth Factor Receptor 2 binding peptide: Targeting Vascular Endothelial Cells. European Peptide Symposium 2002, Sorento, Italy, August 30-September 6, 2002
  25. N.F.Voelkel, C. Cool, L. Taraseviciene-Stewart, M. Geraci, M. Yeager, T. Bull, M. Kasper, R.M. Tuder. Janus face of vascular endothelial growth factor: The obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension. Crit Care Med 5:S1-S6, 2002