Faculty

Sally E. Wenzel, M.D.
Professor of Medicine

EDUCATION/TRAINING

University of Florida, Gainesville, FL
1978B.S.Biological Sciences
1981M.D.

North Carolina Baptist Hospital, Winston-Salem, NC
1981–1982InternInternal Medicine
1982–1984ResidentInternal Medicine

Medical College of Virginia, Richmond, VA
1984–1986FellowPulmonary Medicine

 UCD
4200 E. Ninth Ave.
Denver, CO 80262
Tel: 303.398.1521 (1783)
wenzels@njc.org

PROFESSIONAL EXPERIENCE

1986–1987
Clinical Instructor and Research Fellow, Medical College of Virginia, Richmond, VA

1987–1988
Instructor/Fellow, National Jewish Center for Immunology & Respiratory Medicine & University of Colorado Denver (UCD), Denver, CO

1988–1995
Assistant Professor, National Jewish Center for Immunology & Respiratory Medicine & UCD, Denver, CO

1995–2001
Associate Professor, National Jewish Medical & Research Center and UCD, Denver, CO

1998–present
Co-Director, Clinical Research Unit, Medicine, National Jewish Medical & Research Center, Denver, CO

2001–present
Professor, National Jewish Medical & Research Center and University of Colorado Denver, Denver, CO

SELECTED PUBLICATIONS

  1. Wenzel SE, Fowler AA, Schwartz LB. Activation of pulmonary mast cells by bronchoalveolar allergen challenge: In Vivo release of histamine and tryptase in atopic subjects with and without asthma. Am Rev Respir Dis 137:1002-1008, 1988.
  2. Wenzel SE, Westcott JY, Smith HR, Larsen GL. Spectrum of prostanoid release following bronchoalveolar allergen challenge in atopic asthmatics and control groups: An alteration in the ratio of bronchoconstrictive to bronchoprotective mediators. Am Rev Respir Dis 139:450-457, 1989.
  3. Wenzel SE, Larsen GL, Johnston K, Voelkel NF, Westcott JY. Elevated levels of leukotriene C4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am Rev Respir Dis 142:112-119, 1990.
  4. Westcott JY, Johnston K, Batt RA, Wenzel SE, Voelkel NF. Measurement of peptidoleukotrienes in biologic fluid. J Appl Physiol 68:2640-2648, 1990.
  5. Wenzel SE, Westcott JY, Larsen GL. Early bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic asthmatics: Relationship to the development of late asthmatic responses. J Allergy Clin Immunol 87:540-548, 1991.
  6. Hamilos DL, Oppenheimer TJ, Nelson HS, Wenzel SE. Suggested approaches for research protocols involving the potential for life-threatening reactions. J Allergy Clin Immunol 91:1101-1109, 1993.
  7. Wenzel SE, Trudeau JB, Riches DWH, Westcott JY, Henson PM. Peritoneal lavage fluid alters eicosanoid production in developing murine bone marrow macrophages towards that of a resident cell. Inflammation 17:743-756, 1993.
  8. Westcott JY, Voelkel NF, Jones K, Wenzel SE. Inactivation of Leukotriene C4 in airways and subsequent urinary leukotriene E4 excretion in normal and asthmatic subjects. Am Rev Respir Dis 148:1244-1251, 1993.
  9. Israel E, Rubin P, Kemp JP, Grossman J (et al), Wenzel S, Cohn J, Pearlman H, Drazen J. The effect of inhibition of 5-lipoxygenase by Zileuton in mild to moderate asthma. Annals Int Med 119:1059-1066, 1993.
  10. Wenzel SE. Asthma as an inflammatory disease. Annals of Allergy 72:261-271, 1994.
  11. Wenzel SE, Trudeau JB, Westcott JY, Beam WK, Martin RJ. Single oral dose prednisone decreases leukotriene B4 production by alveolar macrophages from nocturnal asthmatics, but not control groups: Relationship to changes in cellular influx and FEV1. J Allergy Clin Immunol 94:870-881, 1994.
  12. Wenzel SE. The role of inflammation in asthma. National Heart, Lung and Blood Institute and the National Asthma Education and Prevention Program (Monograph), 1994.
  13. Wenzel SE, Trudeau JB, Kaminsky DA, Cohn J, Martin RJ, Westcott JY. Effect of 5 lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma. Am J Resp Crit Care Med 152:897-905, 1995.
  14. Kaminsky, Irvin CG, Feldsein DC, Gurka DA, Wenzel SE. The effects of cold, dry air challenge on peripheral resistance in normals and asthmatics. Am J Resp Crit Care Med 152:1784-1790, 1995.
  15. Borish L, Aarons A, Rumbyrt J, Cvietusa P, Negri J, Wenzel SE. Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol 97:1288-1296, 1996.
  16. Kaminsky D, Wenzel SE, Carcano C, Gurka D, Feldsien D, Irvin CG. Hyperpnea-induced changes in paren-chymal lung mechanics in normal subjects and in asthmatics. Am J Respir Crit Care Med 155:1260-1266, 1997.
  17. Westcott JY, Sloan S, Wenzel SE. Immunofiltration purification for urinary leukotriene E4 quantitation. Analytical Biochem 248:202-210, 1997.
  18. Wenzel SE, Szefler SJ, Leung DYM, Sloan SI, Rex MD, Martin RJ. Bronchoscopic evaluation of severe asthma: persistent inflammation despite high dose glucocorticoids. Am J Respir Crit Care Med 156:737-743, 1997.
  19. Wenzel SE. New approaches to anti-inflammatory therapy for asthma. Am J Med 104:287-300, 1998.
  20. Wenzel SE. Factors determining the severity of asthma. Clin and Exp Allergy 28, Supp. 5:119-125, 1998.
  21. Wenzel SE. Should antileukotriene therapies be used instead of inhaled corticosteroids in asthma? Am J Respir Crit Care Med 158:1699-1701, 1998.
  22. Chu HW, Halliday JL, Martin RJ, Leung DYM, Szefler SJ, Wenzel SE. Collagen deposition in large airways does not differentiate severe asthma from milder forms of the disease. Am J Respir Crit Care Med 158:1936-1944, 1998.
  23. Wenzel SE. Antileukotriene drugs in the management of asthma. JAMA 280:2068-2069, 1998.
  24. Hamid QA, Wenzel SE, Hauk PJ, Tsicopoulos A, Wallaert B, Lafitte J-J, Chrousos GP, Szefler SJ, Leung DYM. Increased glucocorticoid receptor b in airway cells of glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 159:1600-1604, 1999.
  25. Wenzel SE. Inflammation, leukotrienes and the pathogenesis of the late asthmatic response. Clin Exp Allergy 29:1-3, 1999.
  26. Simon RA, Wenzel SE. Introduction. The immunobiology of leukotriene inhibitors. Clin Rev Allergy Immunol 17:1-2, 1999.
  27. Wenzel S, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, Chu HW. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 160:1001-1008, 1999.
  28. Wenzel SE. Leukotriene Receptor Antagonists and Related Compounds. Canadian Respir J 6:189-193, 1999.
  29. Krawiec ME and Wenzel SE. Use of leukotriene antagonists in childhood asthma. Current Opinion in Pediatrics 11:540-547, 1999
  30. Longphre M, Li D, Gallup M, Drori E, Ordonez CL, Redman T, Wenzel S, Bice DE, Fahy JV and Basbaum C. Lymphocyte-derived factors directly stimulate mucin transcription in allergic airways disease. J Clin Invest 104:1375-82, 1999.
  31. Wenzel SE, Severe Asthma: Defining, diagnosing and treating. J Respir Dis 21:164-173, 2000.
  32. Wenzel SE, Monograph Editor, Asthma and the Small Airways. American Thoracic Society (Monograph), 2000.
  33. Busse WW, Wenzel SE. Large and small airway dysfunction in asthma: Rationale for treating the entire airway. American Thoracic Society (Monograph),17-23, 2000.
  34. Busse WW, Banks-Schlegel S, Wenzel SE. NHLBI Workshop summary: Pathophysiology of severe asthma. J Allergy Clin Immun 106(6):1033-1042, 2000.
  35. Chu HW, Trudeau JB, Balzar S, Wenzel SE. Peripheral blood and airway tissue expression of transforming growth factor beta by neutrophils in asthmatic subjects and normal control subjects. J Allergy Clin Immun 106(6):1115-1123, 2000.
  36. Wenzel SE, Fahy JV, Irvin C, Peters SP, Spector S, Szefler SJ. Proceedings of the ATS workshop on refractory asthma: Current understanding, recommendations and unanswered questions. Am J Resp Crit Care Med 162:2341-2351, 2000.
  37. Wenzel SE, Morgan K, Griffin R, Stanford R, Edwards L, Wamboldt FS, Rogenes P. Improvement in health care utilization and pulmonary function with fluticasone propionate in patients with steroid-dependent asthma at a national asthma referral center. J Asthma 38:347-354, 2001.
  38. Krawiec M, Chu HW, Westcott J, Balzar S, Trudeau J, Wenzel S. Persistent wheezing in very young children is associated with lower respiratory inflammation. Am J Respir Crit Care Med 163: 1338-1343, 2001.