Faculty

G. Scott Worthen, M.D.
Senior Professor of Medicine

EDUCATION/TRAINING

Harvard College, Cambridge, Mass
1973A.B.History & Science

Harvard Medical School
1977M.D.

University of Colorado HSC, Denver, CO
1996-1999Post-DocDevelopmental Genetics

Beth Israel Hospital, Boston, MA
1977-1980Intern/ResidentInternal Medicine

University of Colorado School of Medicine, Denver, CO
1980-1983FellowPulmonary Medicine

 UCD
4200 E. Ninth Ave.
Denver, CO 80262
Tel: 303.398.1640 (1380)
worthens@njc.org

PROFESSIONAL EXPERIENCE

1982-1983
Max and Sara Cowan Endowment Fellowship, National Jewish Center for Immunology and Respiratory Medicine (NJCIRM), Denver, Colorado

1983-
Staff Clinician, Department of Medicine, NJCIRM, Denver, Colorado

1984-1989
Assistant Professor, Department of Medicine, Division of Pulmonary Medicine, University of Colorado School of Medicine, Denver, Colorado

1990-1994
Head, Pulmonary Division, Department of Medicine, NJCIRM, Denver, Colorado

1990-1995
Associate Professor, Department of Medicine, Division of Pulmonary Sciences, University of Colorado School of Medicine, Denver, Colorado

1996-
Professor, Department of Medicine, Division of Pulmonary Sciences, University of Colorado School of Medicine, Denver, Colorado

SELECTED PUBLICATIONS

  1. Erzurum SC, Downey GP, Doherty DE, Schwab B, III, Elson EL, Worthen GS. Mechanisms of lipopolysaccharide-induced neutrophil retention: Relative contributions of adhesive and cellular mechanical properties. J Immunol 1992; 149:154-162.
  2. Parsons PE, Moore FA, Moore EE, Iklé DN, Henson PM, Worthen GS. Studies on the role of tumor necrosis factor in adult respiratory distress syndrome. Am Rev Respir Dis 1992; 146:694-700.
  3. Lien DC, Worthen GS, Henson PM, Bethel RA. Platelet-activating factor causes neutrophil accumulation and neutrophil-mediated increased vascular permeability in canine trachea. Am Rev Respir Dis 1992; 145:693-700.
  4. Bethel RA, Worthen GS, Henson PM, Lien DC. Effects of neutrophil depletion and repletion on PAF-induced hyperresponsiveness of canine trachea. J Appl Physiol 1992; 73:2413-2419.
  5. Downey GP, Worthen GS, Henson PM, Hyde DM. Neutrophil sequestration and migration in localized pulmonary inflammation: Capillary localization and migration across the intra-alveolar septum. Am Rev Respir Dis 1993; 147:168-176.
  6. Worthen GS, Avdi N, Vukajlovich S, Tobias PS. Neutrophil adherence induced by lipopolysaccharide in vitro: Role of plasma-mediated lipopolysaccharide disaggregation. J Clin Invest 1993; 90:2526-2535.
  7. Buhl AM, Eisfelder BJ, Worthen GS, Johnson GL, Russell M. Selective coupling of the human anaphylatoxin C5a receptor and a16 in human kidney 293 cells. FEBS Lett 1993; 323:132-134.
  8. Worthen GS, Henson PM, Rosengren S, Downey GP, Hyde DM. Neutrophils increase volume during migration in vivo and in vitro. Am J Respir Cell Mol Biol 1994; 10:1-7.
  9. Hellewell PG, Young SK, Henson PM, Worthen GS. Disparate role of the b2 integrin CD18 in the local accumulation of neutrophils in pulmonary and cutaneous inflammation in the rabbit. Am J Resp Cell Mol Biol 1994; 10:391-398.
  10. Acute Lung Injury. Thomas L. Petty 36th Annual Aspen Lung Conference. Worthen GS, Parsons PE (Eds.). Chest 1994; 105:43S-132S.
  11. Rosengren S, Henson PM, Worthen GS. Migration-associated volume changes in neutrophils facilitate the migratory process. Am. J. Physiol Cell Physiol 1994; 267:C1623-C1632.
  12. Worthen GS, Avdi N, Buhl AM, Johnson GL. FMLP activates Ras and Raf in human neutrophils: Potential role in regulation of MAP kinase. J Clin Invest 1994; 94:815-823.
  13. Doherty DE, Downey GP, Erzurum SC, Schwab B, Elson E, Worthen GS. Lipopolysaccharide-induced monocyte retention in the rabbit lung: The role of monocyte stiffness, actin assembly, and adherence. J Immunol 1994; 153:241-255.
  14. Buhl AM, Avdi N, Worthen GS, Johnson GL. Mapping of the C5a receptor signal transduction in human neutrophils. Proc Natl Acad Sci USA 1994; 91:9190-9194.
  15. Henson PM, Riches DWH, Worthen GS, Doherty DE, Parsons PE. LPS and cytokines in lung injury. In: Brigham KL (Ed.). Endotoxin and the Lungs. New York:Marcel Dekker, Inc. 1994:267-304.
  16. Hellewell PG, Henson PM, Young SK, Worthen GS. Paradoxic effect of ibuprofen on neutrophil accumulation in pulmonary and cutaneous inflammation. Am J Respir Crit Care Med 1995; 151:1218-1227.
  17. Parsons PE, Gillespie MMK, Moore EE, Moore FA, Worthen GS. Neutrophil response to endotoxin in the adult respiratory distress syndrome: role of CD14. Am J Respir Cell Mol Biol 1995; 13:152-160.
  18. Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL. Interleukin-8 regulation of the ras/raf/mitogen-activated protein kinase pathway in human neutrophils. J Biol Chem 1996; 271:2832-2838.
  19. Nick JA, Avdi NJ, Gerwins P, Johnson GL, Worthen GS. Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. J Immunol 1996; 156:4867-4875.
  20. Avdi NJ, Winston BW, Russell M, Young SK, Johnson GL, Worthen GS. Activation of MEKK by FMLP in human neutrophils: mapping pathways for MAP kinase activation. J Biol Chem 1996; 271:33598-33606.
  21. Nick JA, Avdi NJ, Young SK, Knall C, Gerwins P, Johnson GL, Worthen GS. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J Clin Invest 1997; 99:975-986.
  22. Hyde DM, Downey GP, Tablin F, Rosengren S, Giclas PC, Henson PM, Worthen GS. Age-dependent neutrophil and blood flow responsiveness in acute pulmonary inflammation in rabbits. Am J Physiol (Lung Cell and Mol Biol) 1997; 272:L471-L478.
  23. Knall C, Worthen G, Johnson GL. Interleukin-8 stimulated phosphatidylinositol 3-kinase activity regulates the migration of human neutrophils independent of ERK and p38 mitogen activated protein kinases. Proc. Natl. Acad. Sci USA, 1997, 94:3052-3057.
  24. Brown KK, Henson PM, Maclouf J, Moyle M, Ely JA, Worthen GS. Neutrophil-platelet adhesion: relative roles of platelet P-selectin and neutrophil b2 (CD18) integrins. Am. J. Respir. Cell Mol. Biol. 18:100-110, 1998.
  25. Billstrom SM, Avdi N, Johnson GL, Worthen GS. Intracellular signaling by the chemokine receptor US28 during human cytomegalovirus infection. J. Virology, 72:5535-5544, 1998.
  26. Frasch SC, Nick JA, Fadok V, Bratton DL, Worthen GS, Henson PM. p38-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J. Biol. Chem. 273:8389-8397, 1998.
  27. Nick JA, Avdi NJ, Young SK, Lehman LA, McDonald PP, Frasch SC, Billstrom MA, Henson PM, Johnson GL, Worthen GS. Selective-activation and functional significance of p38a mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils. J Clin Invest. 103:851-858, 1999.
  28. Nick JA, Avdi NJ, Young SK, McDonald PP, Billstrom MA, Henson PM, Johnson GL, Worthen GS. An intracellular signaling pathway linking LPS stimulation to cellular responses of the human neutrophil: the p38 MAP kinase cascade and its functional significance. Chest. 116:54S-55S, 1999.
  29. Kench, JA, Russell DM, Fadok VA, Young SK, Worthen GS, Jones-Carson J, Henson JE, Henson PM, Nemazee D. Aberrant wound healing and TGF-beta production in the autoimmune-prone MRL/+ mouse. Clin. Immunol. 92(3):300-310, 1999.
  30. Nick JA, Young SK, Brown K, Avdi NJ, Arndt PG, Suratt BT, Janes MS, Henson PM, Worthen GS. Role of p38 MAP kinase in a murine model of pulmonary inflammation. J Immunol. 164:2151-2159, 2000.
  31. Avdi N, Nick JA, McDonald PP, Billstrom MA, Henson PM, Johnson GL, Worthen GS. TNF-a activation of the JNK pathway in human neutrophils: integrin involvement in a pathway leading from cytoplasmic tyrosine kinases to apoptosis. J Biol. Chem. 276(3):2189-2199, 2001.
  32. Billstrom-Schroeder M, Worthen GS. Viral Regulation of RANTES Expression during Human CMV infection of Endothelial Cells. J Virology, 75:3383-3390, 2001.
  33. Suratt BT, Young SK, Lieber J, Nick JA, Henson PM, Worthen GS. Neutrophil maturation and activation determine anatomic site of clearance from circulation. American Journal of Physiology, 281:L913-L921, 2001.