Principal Investigator/Program Director (Last, First, Middle):

Positions:

2003– Present Assoc. Prof. Radiology (2005), Director – Bio-Imaging Research Laboratory University Of Colorado Hospital / Health Sciences Center, Denver, Co

2003 Associate Director Medical Diagnostics, Perceptive Informatics, Inc., Boston, Ma

2000-2003 Asst. Prof. Radiology, Technical Director – Brain Imaging Research Lab, Medical Physicist, University Of Colorado Hospital/Health Sciences Center, Denver, Co

2000 – 2001 Consultant, Medical Media Systems, Boston, Ma

1999 – 2000 Technical Consultant – Sales, Domain Pharma Corporation, Lexington, Ma

1996 -1999 Asst. Prof. Radiology (May 1998), Medical Physicist, University Of Colorado Hospital / Health Sciences Center, Denver, Co, Brain Imaging Center, Dept. Of Radiology-Mri, Denver, Co

1996 Imaging Scientist, University of Colorado Denver - Center For Human Simulation, Denver, Co

1993-1996 Research Associate, Lockheed / Eg&G Idaho - Idaho National Engineering Laboratory, Idaho Falls, Id

1993-1996 Technical Asst, Rensselaer Polytechnic Institute, Troy, Ny

1994-1995 Technical Asst, Albany Medical Center, Albany, Ny

1992 Research Associate, Eg&G Idaho - Idaho National Engineering Laboratory, Idaho Falls, Id

Honors:

1992 American Legion Scholastic Excellence Award

1992 Frank G. Morrow Memorial Award

1993 National Collegiate Engineering Award

1993 All-American Scholar Award

1993 National Dean’s List

1993 Alpha Nu Sigma Honor Society Award (American Nuclear Society)

Selected peer-reviewed publications (in chronological order):

1. Miller, DE, "ATR-2D Pre-test predictions for cycle 97B-1, Rev. A," Idaho National Engineering Laboratory, NPR-MHTGR-0472, Rev. A, 24 Jul 1992.

2. Miller, DE, ATR-2D Pre-test predictions for cycle 97B-1, Idaho National Engineering Laboratory, NPR-MHTGR-0472, 24 Jul 1992.

3. Miller, DE, Post-test thermal analysis of ATR-2A test assembly, Idaho National Engineering Laboratory, NPR-MHTGR-0470, 30 Jul 1992.

4. Miller, DE, ATR-2D as-run thermal analysis for cycle 97A, Idaho National Engineering Laboratory, NPR-MHTGR-0483, 14 Aug 1992.

5. Miller, DE, Post-test thermal analysis of ATR-2B test assembly, Idaho National Engineering Laboratory, NPR-MHTGR-0641, 22 Jun 1993.

6. Miller, DE, Calculation of centerline dose and flux values for the TORT phantom and heterogeneous dog models, Idaho National Engineering Laboratory, PBF-BNCT-196, 7 Jan 1994.

7. 21. Simon, JH, Jacobs LD, Campion M, Wende K, Simonian N, Cookfair DL, Rudick RA, Herndon RM, Richert JR, Salazar AM, Alam JJ, Fischer JS, Goodkin DE, Granger CV, Lajaunie M, Martens-Davidson AL, Meyer MJ, Sheeder J, Choi K, Scherzinger AL, Bartoszak DM, Bourdette DN, Braiman J, Brownscheidle CM, Coats ME, Cohan SL, Dougherty DS, Kinkel RP, Mass MK, Munschauer FE, Priore RL, Pullicino PM, Scherokman BJ, Weinstock-Guttman B, Whitham RH, and The Multiple Sclerosis Collaborative Research Group (MSCRG). Magnetic Resonance Studies of Intramuscular r-Interferon Beta-1a for Relapsing Multiple Sclerosis. Annals of Neurology, 1998; 43:79-87.

8. Goodkin DE, Priore RL, Wende KE, Campion M, Bourdette DN, Herndon RM, Fischer JS, Jacobs LD, Cookfair DL, Rudick RA, Richert JR, Salazar AM, Granger CV, Simon JH, Alam JJ, Bartoszak DM, Braiman J, Brownscheidle CM, Coats ME, Cohan SL, Dougherty DS, Kinkel RP, Mass MK, Munschauer FE 3rd, Whitham RH and The Multiple Sclerosis Collaborative Research Group (MSCRG). Comparing the Ability of Various Compositive Outcomes to Discriminate Treatment Effects in MS Clinical Trials. The Multiple Sclerosis Collaborative Research Group (MSCRG). Mult Scler 1998;4(6):480-486

9. Rudick RA, Simonian NA, Alam JA, Campion M, Scaramucci JO, Jones W, Coats ME, Goodkin DE, Weinstock-Guttman B, Herndon RM, Mass MK, Richert JR, Salazar AM, Munschauer FE, Cookfair DL, Simon JH, Jacobs LD, and The Multiple Sclerosis Collaborative Research Group (MSCRG). Incidence and Significance of Neutralizing Antibodies to Interferon Beta-1a in Multiple Sclerosis. Neurology 1998;50:1266-1272.

10. Simon JH, Jacobs LK, Campion MK, Rudick RA, Cookfair DL Herndon RM, Richert JR, Salazar AM, Fischer JS, Goodkin DE, Simonian N, Lajaunie M, Miller DE,et al. A Longitudinal Study of Brain Atrophy in Relapsing Multiple Sclerosis, Neurology, Jul 13;53(1):139-148, 1999.

11. Jacobs LD, et al, Intramuscular Interferon Beta-1a Therapy Initiated During a First Demyelinating Event in Multiple Sclerosis, New England Journal of Medicine, Sep 28; 343(13):898-904, 2000.

12. Simon JH, Lull J, Jacobs LD, Rudick RA, Cookfair DL, Herndon RM, Richert JR, Salazar AM, Sheeder J, Miller D, et al. A longitudinal study of T1 hypointense lesions in relapsing MS, MSCRG trial of Interferon b-1a, Neurology, 55(20): 185-192, July 2000.

13. CHAMPS Study Group, et al, Interferon b-1a for Optic Neuritis Patients at High Risk for Multiple Sclerosis, American Journal of Ophthalmology, 123(4): 463-471, October 2001.

14. Tanabe JL, Miller DE, Meyer FG, Tregellas J, Comparison of Detrending Methods for Optimal fMRI Pre-processing, Neuroimage, Apr, 15:902-907, 2002.

15. CHAMPS Study Group, Baseline MRI characteristics of patients at high risk for multiple sclerosis: results from the CHAMPS trial. Controlled High-Risk Subjects Avonex Multiple Sclerosis Prevention Study, Mult. Sclerosis, Aug, 8(4):330-8, 2002.

16. CHAMPS Study Group, Predictors of short-term disease activity following a first clinical demyelinating event: analysis of the CHAMPS placebo group, Mult Sclerosis, Oct, 8(5):405-9, 2002.

17. CHAMPS Study Group, MRI predictors of early conversion to clinically definite MS in the CHAMPS placebo group, Neurology, Oct 8, 59(7):998-1005, 2002.

18. Tanabe JL, Tregellas JR, Miller DE, Ross RG, Freedman R, Brain Activation During Smooth Pursuit Eye Movements, Neuroimage, Nov, 17(3):1315-24, 2002.

19. Tregellas JR, Tanabe JL, Miller DE, Monitoring Eye Movements During fMRI Tasks with Echo Planar Images, Human Brain Mapping, Dec, 17(4):237-43, 2002.

20. Weiland DA, Lynch DA, Jensen S, Newell JD, Miller DE, Crausman RS, Kuhn C, Kern DG.Thin-section CT findings in flock worker’s lung, a work-related interstitial lung disease.Radiology,Apr, 227(1):222-31, 2003.

21. Tregellas JR, Tanabe JL, Miller DE, Ross RG, Olincy A, Freedman R, Neurobiology of Smooth Pursuit Eye Movement Deficits in Schizophrenia: An fMRI Study. American Journal of Psychiatry, 161:315-321, 2004.

22. Coombs BD, Best A, Brown MS, Miller DE, Corboy J, Baier M, Simon JH, Multiple sclerosis pathology in the normal and abnormal appearing white matter of the corpus callosum by diffusion tensor imaging, Multiple Sclerosis, 10:1-6, 2004.

23. Champions Study Group (Kinkel RP, Kollman C, O’Connor P, Murray TJ, Simon J, and Champions Investigators Group). IM Interferon β-1 Delays Definite Multiple Sclerosis 5 years after a First Demyelinating Event. Neurology, 2006; 66:678-684.

24. Simon JH, Zhang S, Laidlaw DE, Miller DE, Brown M, Corboy J, Bennett J. Identification of Fibers at Risk for Degeneration by Diffusion Tractography in Patients at High Risk for MS after a Clinically Isolated Syndrome. JMRI, 2006; accepted.

25. Walker SA, Miller DE, Tanabe J, Bilateral Spatial Filtering: Refining Methods for Localizing Brain Activation in the Presence of Parenchymal Abnormalities, NeuroImage, 2006 Nov 1;33(2):564-9.

26. Best AC, Meng J, Lynch AM, Bozic CM, Miller D, Grunwald G, Lynch DA, Physiology, Quantitative CT, and Semiquantitative CT as Predictors of Mortality in Idiopathis Pulmonary Fibrosis, Radiology, Accepted March, 2007

27. Jody Tanabe, Thomas Crowley, Kent Hutchison, David Miller, Glyn Johnson, Yiping P. Du, Gary Zerbe, Robert Freedman, Striatal CBF during acute nicotine and withdrawal, Neuropsychopharmacology, Accepted, March 2007.

Research Support:

1R01AG022551-01A1 - NIH James P. Grigsby, Ph.D. (PI) 2005-2009

Chemotherapy and Cognition in Older Breast Cancer Patients

Role: Co-Investigator: data management, image analysis / segmentation

1R01AR049152 - NIH Elizabeth Kozora, Ph.D. (PI) 2004-2008

MRI and MRS Correlates of Cognitive Function in Systemic Lupus Erythematosus (SLE).

Role: Co-investigator: data management, 3D volumetrics, segmentation

PVARF Contract – David E. Miller, Ph.D. (PI) 2007-2008

Subcontract support for two Phase II clinical trials in multiple sclerosis.

Role: PI, data management, image QA, image analysis / segmentation, software development, 21 CFR 11 compliance issues

University of Colorado Denver, Dept. of Radiology

Role: Asst. Radiation Safety Officer and PI for Co-60 Irradiator

Dates: 2007-2008 (Annual Renewal)

University of Colorado Hospital, Medical Physics Contract

Role: Medical Physics support for Radiology, Nuclear Medicine

Dates: 2007-2008 (Annual Renewal)



BIOGRAPHICAL SKETCH
NAME David E. Miller, PhD		POSITION TITLE Associate Professor, Radiology
EDUCATION/TRAINING
INSTITUTION AND LOCATION	DEGREE (if applicable)		YEAR(s)	FIELD OF STUDY
Rensselaer Polytechnic Institute Troy, NY	BS		1987-1989 1991-1993	Nuclear Engineering
Rensselaer Polytechnic Institute Troy, NY	MS		1993-1994	Nuclear Engineering
Rensselaer Polytechnic Institute Troy, NY	PhD		1993-1996	Nuclear Science & Engineering
University of Colorado Denver Denver, CO	MS		1996-2001	Medical Physics

BIOGRAPHICAL SKETCH