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BIOGRAPHICAL SKETCH
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NAME Ann L Scherzinger, Ph. D. |
POSITION TITLE Associate Professor |
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EDUCATION/TRAINING |
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INSTITUTION AND LOCATION |
DEGREE (if applicable) |
YEAR(s) |
FIELD OF STUDY |
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Whitman College, Walla Walla, WA |
BA |
1971 |
Chemistry |
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U of Illinois, Urbana, IL |
PhD |
1977 |
Physical Chemistry |
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U of Colorado School of Medicine, Denver, CO |
Fellow |
1982 |
Radiological Sciences |
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Positions:
1977-1999 Research Fellow, Department of Radiology, UCD, Denver, CO
1982-1999 Assistant Professor (some part time), Department of Radiology, UCD, Denver, CO
1997-present Diagnostic Physicist and RIS/PACS Administration Support, U of Colorado Hospital
2000-present Associate Professor and Chief of Division of Radiological Sciences, UCD, Denver, CO
2003-present Adjunct Professor, Dept of Computer Science and Engineering, U of Colorado at Denver
2005-2006 Teaching Scholars Program, UCD
Selected peer-reviewed publications (in chronological order):
Scherzinger AL, Carson PL, Clayman W, Carter W, Johnson ML, Rashbaun C. A tissue equivalent upper abdominal phantom. J Ultras Med 1983;2:455-462.
Scherzinger AL. Description of radiologic modalities (Ultrasound). In: Selection and Performance Evaluation of Radiologic Equipment. Ed. Hendee WR. The Williams and Wilkins Company, Baltimore MD 1985:236-239.
Carson PL, Scherzinger AL, Meyer CR, Moore GE, Jobe W, Samuels B. Lesion detectability in ultrasonic computed tomography of symptomatic breast patients. Invest Rad 1988;23:421-427.
Everson GT, Scherzinger AL, Leff N, Reichen J, Lezotte D, Manco-Johnson ML, Gabow P. Polycystic liver disease: Quantitation of parenchymal and cyst volumes from CT images and clinical correlates of hepatic cysts. Hepatol 1988;8(6):1627-34.
Scherzinger AL, Bellgam RA, Carson PL, Meyer CR, Sutherland JV, Bookstein FL, Silver TM. Assessment of ultrasonic computed tomography in symptomatic breast patients by discriminant analysis. Ultras Med Biol 1989;15:21-28.
Raff U, Vargas P, Rodriguez L, Scherzinger AL, Groves BM. Computation of left ventricular volume curves from gated blood pool studies without explicit use of edge detection algorithms: Concise communication. Internatl J Cardiac Imag, 1994;11:9-18.
Raff U, Scherzinger AL, Vargas P, Simon JH. Quantitation of grey matter, white matter and cerebral spinal fluid from spin-echo MR images using an artificial neural network technique. Medical Physics, 1994;21(12):1933-1942.
Shrestha R, McKinley C, Russ P, Scherzinger A, Bonner R, Showalter R, Everson G. Estrogens inhibit the metabolism of antipyrine in postmenopausal women with autosomal dominant polycystic disease (ADPD). Gastroenterology 1994;106(4):Part 2:A985.
Scherzinger AL, Spitzer VM, Kilcoyne R, Pelster H, Rush C, Reinig K, Whitlock DG. Interactive computer control of the "Video 3D atlas of human anatomy-the lower extremity" as a teaching aid. SCAR 1994, Computer Applications to Assist Radiologists. Eds: Boehme JM, Rowberg AH, Wolfman NT. Symposia Foundation, Carlsbad, CA, 1994:784-786.
Spitzer VM, Ackerman M, Scherzinger AL, Whitlock D. The Visible Human Male: A Technical Report. JAMIA 1996;3(2):118-130.
Simon JH, Scherzinger A, Raff U, Li Z. Computerized Lesion Volume Quantitation in Multiple Sclerosis. AJNR, 1997, 1997;18:580-582.
Raff U, Vargas PF, Rojas GM, Scherzinger AL, Simon JH. Quantitation of T2 Lesion Load in Multiple Sclerosis with Magnetic Resonance Imaging. Acad Radiol, 1997; 4:431-437.
Spitzer VM, Scherzinger AL. The Visible Human: A three dimensional anatomical database. In: Humans to Proteins, Advances in Computational Life Sciences, Vol 2. Ed. Michalewicz MT. CSIRO Publishing, Collingwood, VIC, Australia, 1998:1-16
Hill JO, Sidney S, Lewis CE, Scherzinger AL, Stamm ER. Racial Differences in Amounts of Visceral Adipose Tissue in Young Adults: The Cardia Study. Am J Clin Nutrition, 1999; 69(3):381-387.
Sidney S, Lewis CE, Hill JO, Quesenbery C, Stamm E, Scherzinger A, Tolan K, Ettinger B. Association of Total and Central Adiposity Measures with Fasting Insulin in a Biracial Population of Young Adults with Normal Glucose Tolerance: The Cardia Study. Obesity Research, 1999; 7(3):265-272..
Harris TB. Visser M. Everhart J. Cauley J. Tylavsky F. Fuerst T. Zamboni M. Taaffe D. Resnick HE. Scherzinger A. Nevitt M. Waist circumference and sagittal diameter reflect total body fat better than visceral fat in older men and women. The Health, Aging and Body Composition Study. Ann NY Acad Sci. 904:462, 2000
Goodpaster BH. Carlson CL. Visser M. Kelley DE. Scherzinger AL. Harris TB. Stamm E. Newman AB. Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study. J Appl Physiol. 90: 2157-2165, 2001
Kosmiski LA, Kuritzkes DR, Lichtenstein KA, Glueck DH, Goutley PJ, Stamm ER, Scherzinger AL, Eckel RH. Fat distribution and metabolic changes are strongly correlated and energy expenditure is increased in the HIV lipodystrophy syndrome. AIDS. 15: 1993-2000, 2001
Harris JG, Young DA, Rojas DC, Cajade-Law A, Scherzinger AL, Naroz S, Adler LE, Cullum, CM. Simon J, Freedman R. Increased hippocampal volume in schizophrenics’ parents with ancestral history of schizophrenia. Schizophrenia Research 55:11-17, 2002.
Diabetes Prevention Program Research Group. Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin. New Eng J of Med. 346: 393-403, 2002.
Wagenknecht LE, Langefeld CD, Scherzinger AL, Norris JM, Haffner SM, Saad MF, and Bergman RN, Insulin Sensitivity, Insulin Secretion, and Abdominal Fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study, Diabetes 52: 2490-2496, 2003.
Mitchell BD, Zaccaro D, Wagenknecht LE, Scherzinger AL, Bergman RN, Haffner SM, Hokanson J, Norris JM, Rotter JI, Saad M. Insulin sensitivity, body fat distribution, and family history of diabetes: The IRAS Family Study. Obesity Research (12(5):831-9, 2004
Norris JM, Langefeld CD, Scherzinger AL, Rich SS, Bookman E, Beck SR, Saad MF, Haffner SM, Bergman RN, Bowden DW, Wagenknecht LE. Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: the IRAS Family Study. Int J Obes Relat Metab Disord 29:67-77, 2005
Scherzinger AL, Du Y, Stamm E, Eckel R, Ma J. MRI Adipose Tissue Volume measures: Comparison of SPGR and Fast Two Point Dixon Methods at 3T. Presented at the 14th Scientific Session of the International Society for Magnetic Resonance in Medicine. May 2006.
Spitzer VM, Scherzinger AL. Virtual Anatomy: An Anatomist’s Playground: Clinical Anatomy. 19:192-203, 2006.
Research Support:
Ongoing research projects:
5R01DK061668 Eckel (PI) 8/1/2003 – 5/31/2008
NIH/NIDDK
Genetic Mechanisms in Defense of Adipose Tissue Mass - MR Reading Center
My role is as the director of the MRI Scan reading center with the responsibility to develop the MRI scan process and analyze the MRI images for quantitative measures of body adipose tissue distribution pre and post lipectomy.
Role: Co-Investigator
RO1 DK068001-01A1 Dabela (PI) 9/14/05 - 6/30/07
NIH/NIDDK
EPOCH Exploring Perinatal Outcomes among Children
This is a study of adolescents to allow assessment and disentangling of the effects of exposure to diabetes mellitus in utero and intrauterine growth restraint on body size, fat patterning and insulin resistance markers and features later in childhood. I will be specifically looking at body adiposity by MRI and MRS.
Role: Co-Investigator
1R01HL079611-01 Rewers (PI) 1/01/06 - 12/31/07
NIH/NHLBI
Determinants of Accelerated CVD in Type 1 Diabetes
This study proposes to investigate mechanisms of cardiovascular complications using stored samples from this large cohort study and to include well-characterized study participants in two substudies utilizing novel techniques to: Disentangle the role of inflammation, immune response and diabetes-related metabolic factors in progression of coronary artery calcification. We will specifically be looking at liver-fat and abdominal fat depots by CT.
Role: Co Investigator
2 R01 AG018857-05A2 Kohrt (PI) 7/01/06 - 6/30/11
NIH/NIA
COX Inhibition & Musculoskeletal Responses to Exercise
The global aim of this project is to determine whether inhibition of COX with ibuprofen attenuates musculoskeletal adaptations to exercise
Role: Co-Investigator
TOLTECH Inc. (Whitlock) 9/1/05 - 8/31/07 15%
Surgical Simulation
This contract is to develop 3D computer graphics and computer-based lessons to be used in teaching surgical techniques using a simulator.
Role: Co-investigator
Completed research projects;
1RO1 HL53359-1 Stephen Sidney (PI) 04/01/99-03/31/2003
NIH/NHLBI
Visceral Fat, Metabolic Rate and CVD in Young Adults -
This is a biracial, multi-center study of subjects already enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study to assess the correlation of body composition values to CHD risk factors. My role is as the director of the CT Scan reading center with the responsibility to develop the scan process and analyze the CT images for quantitative measures of body composition.
Role: Co-Investigator
3N01AG062106-008 Steve Cummings, (PI) 06/01/02 - 9/30/03
NIH/NIA
The Dynamics of Health, Aging and Body Composition (HABC) – CT Reading Center
The HABC Study will characterize the extent of change in body composition in older men and women, identify clinical conditions accelerating these changes, and examine the health impact of these changes on strength, endurance, disability and diseases of old age. My role is as the director of the CT Scan reading center with the responsibility to develop the scan process and analyze the CT images for quantitative measures of body composition.
Role: Subcontract PI
2R01HL060944-06A1 Wagenknecht, (PI) 1/15/2005 – 12/31/2006
NIH/NHLBI
Genetics of Adiposity and Glucose Homeostasis - IRAS CT Scan Reading Center
The IRAS Family Study, initially funded as six linked R01s in 1999, is a multicenter project designed to study the genetic epidemiology of adiposity and glucose homeostasis. In this reading center, CT scans are analyzed for measures of abdominal adiposity and liver steatosis.
Role: Subcontract PI
1R01HL067128-01A1 Powell (PI) 6/1/2002 – 3/31/2007
NIH/NHLBI
WISH Sub-study on Fat Patterning in Menopause – CT Reading Center
The aims of this study are to characterize, with CT, the changes in body fat composition for women in the menopause transition. , CT scans are analyzed for measures of abdominal adiposity.
Role: Subcontract PI