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Dawn
Duval, Ph.D.
Assistant Professor
Department of Endocrinology, Diabetes and
Metabolism
Ph.D., Cell and Molecular Pharmacology and
Physiology
University of Nevada, Reno (1994)
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Dr. Duval focuses her research on mechanisms of pituitary-specific
gene expression. Specifically, she is studying the interactions
of the Ets and Pit-1 transcription factors that mediate both
basal expression and Ras stimulation of the prolactin promoter.
She is using biochemical and molecular biology techniques
to dissect the complex protein hierarchy that confers synergistic
transcriptional activation by these factors and targets the
Ras signaling pathway to the prolactin gene promoter.
Selected Publications
D.L. Duval and A. Gutierrez-Hartmann. Editorial:
PRL-Releasing Peptide Stimulation of PRL Gene Transcription—Enter
AKT. Endocrinology
Jan;143(1):11-2, 2002.
K.D. Augustijn, D.L.Duval, R. Wechselberger,
R. Kaptein, A. Gutierrez-Hartmann, P.C. van der Vliet. Structural
characterization of the Pit-1/Ets-1 interaction: Charge dependence
of Pit-1 for Ets-1 binding. Proc.
Natl Acad Sci. 99: 2657-12662, 2002.
D.L. Duval, A.R. Farris, C.C. Quirk, T.M. Nett,
D.L. Hamernik, and C.M. Clay. Responsiveness of the ovine
gonadotropin releasing hormone receptor gene to estradiol
and gonadotropin releasing hormone is not detectable in vitro,
but is revealed in transgenic mice. Endocrinology,
141:1001-1010, 2000.
D.L. Duval, B.S. Ellsworth, and C.M. Clay. Is
gonadotrope expression of the gonadotropin releasing hormone
receptor gene mediated by autocrine/paracrine stimulation
of an activin response element? Endocrinology,
140:1949-1952, 1999.
B.R. White, D.L. Duval, and C.M. Clay. Homologous
regulation of the Gonadotropin-releasing hormone receptor
gene is partially mediated by protein kinase C activation
of an activator protein-1 element. Mol
Endocrinol, 13:566-577, 1999.
D.L. Duval, S.E. Nelson, and C.M. Clay. The tripartite
basal enhancer of the gonadotropin-releasing hormone (GnRH)
receptor gene promoter regulates cell-specific expression
through a novel GnRH Receptor Activating Sequence. Mol
Endocrinol, 11:1814-1821, 1997.
Latest Publications in PubMed
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