William W. Hay, Jr., M.D. Professor Director, Neonatal Clinical Research Center Scientific Director, Perinatal Research Facility M.D., Yale University Campus Box F441 Perinatal Bldg. 260, Room N/A S/M Pediatrics - Peds Neonatal/Perinatal Ph: 303-724-1600 Bill.Hay@uchsc.edu

Research Interests:

• Perinatal (fetal, placental, maternal) physiology
• Mammalian Carbohydrate Metabolism
• Perinatal Pathophysiology of Diabetes Mellitus
• Intrauterine Growth Restriction
• Neonatal Perinatal Medicine
• Fetal and Neonatal Nutrition
• Pulse Oximetry
  
  

Selected Publications

Anderson, M.S., Thamotharan, M., Kao, D., Devaskar, S.U., Qiao, L., Friedman, J.E., Hay, W.W., Jr. Effects of acute hyperinsulinemia on insulin signal transduction and glucose transporters in ovine fetal skeletal muscle. Am J Physiol Reg Integr Comp Physiol, 288:R473-R481, 2005.

Limesand, S. W., Jensen, J., Hutton, J. C., Hay, W. W., Jr. Diminished b-Cell Replication Contributes to Reduced b-Cell Mass in Fetal Sheep with Intrauterine Growth Restriction. Am J Physiol Reg Integr Comp Physiol 288: R1297-305, 2005.

Wooding, F.B.P., Fowden, A.L., Bell, A.W., Ehrhardt, R.A., Limesand, S.W., Hay, W. W., Jr. Localisation of glucose transport in the ruminant placenta: implications for sequential use of transporter isoforms. Placenta 26: 626-640, 2005.

Limesand, S., Rozance, P., Zerbe, G., Hutton, J., Hay, W. W., Jr. Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction. Endocrinology 147: 1488-97, 2006.

Barry JS, Davidsen ML, Limesand SW, Galan HL, Friedman JE, Regnault TRH, Hay, W. W., Jr. Developmental changes in ovine myocardial glucose transporters and insulin signaling during hyperthermia - induced intrauterine fetal growth restriction. Exp Biol Med 231: 566-575, 2006.

Rozance, P.J., Limesand, S.W., Hay, W. W., Jr. Decreased nutrient stimulated insulin secretion in chronically hypoglycemic late gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endo Metab, in press, 2006.

Brown, L.D., Hay, W. W., Jr. Effect of hyperinsulinemia on amino acid utilization and oxidation independent of glucose metabolism in the ovine fetus. Am J Physiol Endo Metab, in press, 2006.

Latest Publications in PubMed