Lorna Moore Professor Altitude Research Center Ph.D. Campus Box B123 BRB, Room 301A S/M Altitude Research Center Tel 303-315-4480 Lorna.G.Moore@UCHSC.edu

Research Interests:

• maternal physiological adaptation to pregnancy

• health effects of high altitude

• interplay between genetic, physiological and behavioral factors in maternal/child health.

Selected Publications

Moore LG, Shriver M, Bemis L, Vargas E. An evolutionary model for identifying genetic adaptation to high altitude. Adv Exp Med Biol. 2006;588:101-18.

Shriver MD, Mei R, Bigham A, Mao X, Brutsaert TD, Parra EJ, Moore LG. Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping. Adv Exp Med Biol. 2006;588:89-100.

Rockwell LC, Dempsey EC, Moore LG. Chronic hypoxia diminishes the proliferative response of guinea pig uterine artery vascular smooth muscle cells in vitro. High Altitude Medicine & Biology 7:237-244, 2006.

Moore LG and Grover, RF. Jack Reeves and his science. Respir Physiology and Neurobiology, 151:96-108, 2006.

Mateev SN, Mouser R, Young DA, Mecham RP, Moore LG. Chronic hypoxia augments uterine artery distensibility and alters the circumferential wall stress-strain relationship during pregnancy. J Appl Physiol. 2006 Jun;100(6):1842-50

Julian CG, Vargas E, MacCannell W, J. Fernando Armaza JF, S Niermeyer S, Moore, LG. Multigenerational high-altitude ancestry protects against hypoxia-associated reductions in birth weight. Arch Dis Child Fetal Neonatal Ed. 2007 [Feb 28 Epub]

Vargas M, Vargas E, Julian CG, Armaza JF, Rodriguez A, Tellez W, Niermeyer S, Wilson MJ, Parra E, Shriver M, Moore LG. Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude. Am J Physiol [Jun 6 Epub]
.
Wilson MJ, Lopez M, Vargas M, Julian CG, Tellez W, Rodriguez A, Bigham A, Armaza JF, Niermeyer S, Shriver M, Vargas E, Moore LG. Greater uterine artery blood flow during high-altitude pregnancy in indigenous (Andean) than Foreign (European) women. Am J Physiol [Jun 6 Epub].

Mao AY, Bigham AW, Mei R, Gutierrez G, Weiss K, Brutsaert T, Leon-Velarde F, Moore LG, McKeigue P, Shriver MD, Parra EJ. A genome-wide admixture mapping panel for hispanic/latino populations. Am J Hum Genet 2007 Jun;80(6):1171-8. [Apr 20 Epub
]
11. Moore LG, Niermeyer S, Vargas E. Does chronic mountain sickness have perinatal origins? Respir Physiology and Neurobiology (in press).

Jean D, Leal C, Kreimler S, Meijer H, Moore LG. Medical recommendations for women going to altitude: a medical commission UIAA consensus paper. High Altitude Medicine and Biology 6(1): 22-31, 2005

Leon-Velarde F, Maggiorini M, Reeves JT, Aldashev A, Asmus I, Bernardi L, Ge R-L, Hackett P, Kobayashi T, Moore LG, Penaloza D, Richalet J-P, Roach R, Wu T, Vargas E, Zubieta-Castillo G, Zubieta-Calleja G. Consensus Statement on Chronic and Sub-Acute High Altitude Diseases. High Alt Med Biol, 6(2): 147-158, 2005.

Mateev SN, Mouser R, Young DA, Mecham RP, Moore LG. Chronic hypoxia augments uterine artery distensibility and alters the circumferential wall stress-strain relationship during pregnancy. J Appl Physiol 100(6):1842-50, 2006.

Moore LG, Grover RF. Jack Reeves and his science. Respir Physiol Neurobiol. 2006 151(2-3):96-108.

Rockwell LC, Dempsey EC, Moore LG. Chronic hypoxia diminishes the proliferative response of guinea pig uterine artery vascular smooth
muscle cells in vitro. High Alt Med Biol. 2006 Fall;7(3):237-44.

Moore LG, Shriver M, Bemis L, Hickler B, Wilson M, Brutsaert T, Parra E, Vargas E. Maternal adaptation to high-altitude pregnancy: an experiment of nature--a review. Placenta. 2004 Apr;25 Suppl A:S60-71. Review.

Mazzeo RS, Dubay A, Kirsch J, Braun B, Butterfield GE, Rock PB, Wolfel EE, Zamudio S, Moore LG.
Influence of alpha-adrenergic blockade on the catecholamine response to exercise at 4,300 meters. Metabolism. 2003 Nov;52(11):1471-7.

Moore LG. Fetal growth restriction and maternal oxygen transport during high altitude pregnancy.
High Alt Med Biol. 2003 Summer;4(2):141-56. Review.

Latest Publications in PubMed