The limbs of wild type (left) and Wnt7a mutant mice.

My laboratory is interested in the molecular mechanisms regulating vertebrate development. We study the Wnt family of secreted signaling molecules and the T-box family of transcription factors. We have generated mutations in several members of the Wnt gene family to investigate their roles in mouse embryogenesis. The Wnt mutant mice have defects in the limbs, reproductive system, placenta, and central nervous system.

Selected Publications

Carson CT, Pagratis M, Parr BA. Tbx12 regulates eye development in Xenopus embryos. Biochem Biophys Res Commun. 2004 May 28;318(2):485-9.

Nunnally AP, Parr BA. Analysis of Fz10 expression in mouse embryos. Dev Genes Evol. 2004 Mar;214(3):144-8. Epub 2004 Jan 31.

Brown DD, Binder O, Pagratis M, Parr BA, Conlon FL. Developmental expression of the Xenopus laevis Tbx20 orthologue. Dev Genes Evol. 2003 Jan;212(12):604-7. Epub 2002 Oct 31.

Parr BA, Cornish VA, Cybulsky MI, McMahon AP. Wnt7b regulates placental development in mice.
Dev Biol. 2001 Sep 15;237(2):324-32.

Carson CT, Kinzler ER, Parr BA. Tbx12, a novel T-box gene, is expressed during early stages of heart and retinal development. Mech Dev. 2000 Aug;96(1):137-40.

Latest Publications in PubMed