Kenneth R. Shroyer, MD., PhD Professor, Dept. Pathology Director Surgical and Cytopathology Vice Chair Anatomic Pathology Ph.D., (1983) University of Colorado Denver M.D. (1987) University of Colorado Denver UCD at Fitzsimons Campus Box 8104 RC1 North Room 5127 P.O. Box 6511 Aurora, CO 80045 (303) 724-3060 (office) (303) 266-7315 (pager) (303) 315-6721 (fax) Ken.Shroyer@UCHSC.edu

Research Interests:

Dr. Shroyer's research is focused on the identification and validation of novel molecular markers of malignancy as potential diagnostic adjuncts, prognostic indicators, or therapeutic targets. His laboratory pioneered PCR-based methods for the analysis of x-chromosome inactivation in archival tissue specimens, as a marker of monoclonal origin of synchronous versus metastatic endometrial and ovarian cancers and in premalignant lesions of the cervical mucosa. His laboratory was also extensively involved in the evaluation of telomerase expression, as a marker of cell immortality and cancer in both surgical and cytologic specimens. One current focus of investigation is the expression of B7-H4, a recently discovered suppressor of T-cell activation, as a mechanism to block immune surveillance of breast, endometrial, and ovarian cancers. His laboratory is also evaluating a several other novel cancer biomarkers that have been identified by data mining of ESTs and custom cDNA microarrays, in collaboration with the biotechnology sector. Finally, Dr. Shroyer's laboratory continues studies of molecular markers of HPV-mediated cervical dysplasia and carcinoma as diagnostic adjuncts for the triage of patients with cervical cytologic abnormalities.

Selected Publications:

B. Tringler, W. Liu, L. Corral, K.C. Torkko, T. Enomoto, S. Davidson, M.S. Lucia, D.E. Heinz, K.R. Shroyer, B7-H4 overexpression in ovarian carcinoma. Gynecologic Oncology 100: 44-52, 2006.

J. Wilman, L. Golitz, and K.R. Shroyer. Correlation of p16 and pRb expression with HPV detection in Bowens disease. J. Cutaneous Pathol. 33:629-33, 2006.

N.S. Speoelstra, N.G. Manning, Y. Higashi, D. Darling, M. Singh, K.R. Shroyer, R.R. Broaddus, K.B. Horwitz, J.K. Richer. The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers. Cancer Res 66: 3893-3902, 2006.

T. Miyatake, T. Enomoto, Y. Ueda, K.R. Shroyer, T. Yoshizaki, H. Kanao,Y. Ueno, H. Sun, R. Nakashima, K. Yoshino, T. Kimura, T. Haba, K. Wakasa, Y. Murata. Clonality Analysis and HPV Infection in Squamous Metaplasia and Atypical Immature Metaplasia of Uterine Cervix: Is Atypical Immature Metaplasia a Precursor to CIN 3? In Press, Int. J. Gynecol. Pathol.

K.R. Shroyer, D. Heinz, Petra Homer, and M. Singh. Validation of a novel immunocytochemical assay for topoisomerase II alpha and minichromosome maintenance protein 2 expression in cervical cytology. Cancer Cytopathology. August 25, 2006

Owens JM, Shroyer KR, Kingdom TT. Arch Otolaryngol Head Neck Surg. 2006 Jun;132(6):579-87

E.A. Jarboe, L.C. Thompson, D. Heinz, J.A. McGregor, and K.R Shroyer. Telomerase and HPV as Diagnostic Adjuncts for Cervical Dysplasia and Carcinoma. Human Pathol. 35: 396-402, 2004.

B. Tringler, C.J. Gup, and K.R. Shroyer. Correlation between p16 and pRb expression in cervical squamous and glandular neoplasia. Human Pathol. 35: 689-696, 2004.

B. Tringler, S. Zhuo, G. Pilkington, K.C. Torkko, M. Singh, M.S. Lucia, D.E. Heinz, J. Papkoff, and K.R. Shroyer. B7-H4 is highly expressed in ductal and lobular breast cancer. Clin. Cancer Res. 11: 1842-8, 2005.

B. Tringler, W. Liu, L. Corral, K.C. Torkko, T. Enomoto, S. Davidson, M.S. Lucia, D.E. Heinz, and K.R.Shroyer, B7-H4 overexpression in ovarian carcinoma. In Press, Gynecol. Oncol.

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