Margaret E. Wierman Professor Endocrinology M.D., Harvard Medical School Campus Box 8106 Cancer Research Tower (RC1-South), Room 7120 S/M Endocrinology/Metabolism/Diabetes Tel: 303-724-3952 Margaret.Wierman@UCHSC.edu

Research Interests:

Based at the VA Medical Center, Dr. Wierman's basic research interests are in the regulation of the genes that control the reproductive axis. She studies those mechanisms by which gonadal sex steroids and peptide hormones regulate the expression of the gonadotropin releasing hormone (GnRH). Dr. Wierman has cloned the rat GnRH gene and is investigating the mechanisms which control developmental and tissue specific expression of GnRH in neuronal cells. The major goal of her work is to define the mechanisms by which GnRH gene transcription is controlled in order to gain a deeper understanding of the pubertal process, infertility, and hypogonadism.

Selected Publications

Wierman ME, Pawlowski JE, Allen MP, Xu M, Linseman DA, Nielsen-Preiss S. Molecular mechanisms of gonadotropin-releasing hormone neuronal migration. Trends Endocrinol Metab. 2004 Apr;15(3):96-102.

Shattuck TM, Valimaki S, Obara T, Gaz RD, Clark OH, Shoback D, Wierman ME, Tojo K, Robbins CM, Carpten JD, Farnebo LO, Larsson C, Arnold A. Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. N Engl J Med. 2003 Oct 30;349(18):1722-9.

Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RS, Arnold A. Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. Clin Endocrinol (Oxf). 2003 Aug;59(2):180-9.

Allen MP, Xu M, Zeng C, Tobet SA, Wierman ME. Myocyte enhancer factors-2B and -2C are required for adhesion related kinase repression of neuronal gonadotropin releasing hormone gene expression. J Biol Chem. 2000 Dec 15;275(50):39662-70.

Wierman ME. Advances in the diagnosis and management of impotence. Adv Intern Med. 1999;44:1-17. Review.

Latest Publications in PubMed