Virginia D. Winn Assistant Professor Obstetrics and Gynecology Basic Reproductive Sciences M.D.,Ph.D., University of Rochester School of Medicine, 1996 Campus Box 8309 RC1-North, Room 5106 Phone: 303-724-1483 virginia.winn@uchsc.edu

Dr. Virginia Winn is a physician-scientist who studies human placental development and a perinatologist specialising in the care of women with high-risk pregnancies. Dr. Winn has a special interest in women with rheumatologic diseases and pregnancies complicated by preeclampsia. Her research focuses on both normal and abnormal human placentation, in order to better understand pregnancy complications such as preeclampsia. The human placenta is uniquely invasive, with the maternal-fetal interface being a truly chimeric tissue. Understanding the regulation of cytotrophoblast differentiation along the invasive pathway is the primary area of research in the lab, employing a variety of in vivo and in vitro models using human trophoblast cells. The laboratory uses multiple cellular and molecular biology techniques including, cell culture, explants, video microscopy, Q-PCR, western blotting, immunohistochemistry, immunofluorescence, adenoviral transfection and gene expression microarrays.

For more detials please visit the Winn laboratory web site:

Winn Lab Website

Selected Publications

Winn VD, Haimov-Kochman R, Paquet AC, Yang YJ, Madhusudhan MS, Gormley M, Feng KT, Bernlohr DA, McDonagh S, Pereira L, Sali A, Fisher SJ. Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term.
Endocrinology. 2007 Mar;148(3):1059-79.

Haimov-Kochman R, Fisher SJ, Winn VD. Modification of the standard Trizol-based technique improves the integrity of RNA isolated from RNase-rich placental tissue. Clin Chem. 2006 Jan;52(1):159-60.

Winn VD, Sonson J, Filly RA Echogenic intracardiac focus: potential for misdiagnosis. J Ultrasound Med. 2003 Nov;22(11):1207-14

Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest. 2006 Sep 21

Winn VD, O'Banion MK, Young DA. Anti-inflammatory glucocorticoid action: inhibition of griPGHS, a new cyclooxygenase. J Lipid Mediat. 1993 Mar-Apr;6(1-3):101-11.

O'Banion MK, Winn VD, Young DA. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.
Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4888-92.

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