Expression of Sonic Hedgehog, Patched, and Gli1 in the early developing tongues. Dorsal views of (A, C, E) E12, C-R length 7-8 mm, and (B,D,F) E12.5, C-R length 8-9 mm, tongues assayed for expression of these genes by whole mount in situ hybridization. Anterior is to the right. (A) E12 jaw showing broad lingual Shh expression as well as Shh expression in the presumptive circumvallate papilla (arrow) and developing incisors (arrowhead). (B) E12.5 lower jaw with Shh expression clearing along the midline of the tongue and parasagittal rows of expression on either side. (C) E12 tongue with broad lingual Ptc expression. (D) E12.5, Ptc. Note lower expression along the midline, mirroring Shh expression. (E) E12, Gli1. (F) E12.5, Gli1. Scale bars: 500µm.
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