BRISTOW, Michael R., MD, PhD        Cardiology      BRB 123      303-315-3251      Bristow.Michael@UCHSC.edu

RESEARCH INTERESTS:

• Heart Failure
• Receptor-mediated signal transduction
• Altered gene expression in the failing heart
• Adrenergic nervous system in heart failure

• Measurement of low abundance mRNA and mRNA in small tissue samples by RT-PCR
• Radioligand binding techniques and equipment
• Biochemical pharmacologic techniques and equipment
• Techniques and equipment for primary cultures of heart cells
• Variety of transgenic animals relevant to the regulation of myocardial contractile function
• Methodologies for investigating gene expression, adrenergic activity and myocardial function in the intact human heart

• Lowes BD, Minobe WA, Abraham WT, Rizeq MN, Bohlmeyer TJ, Quaife RA, Roden RL, Dutcher DL, Robertson AD, Voelkel NF, Badesch DB, Groves BM, Gilbert EM, Bristow MR. Changes in gene expression in the intact human heart: down-regulation of a -myosin heavy chain in hypertrophied, failing ventricular myocardium. J Clin Invest 100:2315-2324, 1997.

• Zisman LS, Asano K, Dutcher DL, Ferdensi A, Robertson AD, Jenkin M, Bush EW, Bohlmeyer T, Perryman MB, Bristow MR. Differential regulation of cardiac angiotensin converting enzyme binding sites and AT₁ receptor density in the failing human heart. Circulation 98:1735-1741, 1998.

• Bristow MR. b -adrenergic receptor blockade in chronic heart failure. Circulation 101:558-569, 2000.

• Lowes BD, Higginbotham M, Petrovich Bisognano JD, Weinberger HD, Bohlmeyer TJ, Pende A, Raynolds MV, Sastravaha A, Roden RL, Asano K, Blaxall BC, Wu SC, Communal C, Singh K, Colucci WS, Bristow MR, Port JD. Myocardial-directed overexpression of the human beta₁-adrenergic receptor in transgenic mice. J Mol Cell Cardiol 32:817-830, 2000.

• Braunwald EB, Bristow MR. Congestive Heart Failure: Fifty Years of Progress. Circulation 102:IV-14-23, 2000.

• Kinugawa K, Minobe WA, Wood WM, Ridgway EC, Baxter JD, Ribeiro RCJ, Tawadrous MF, Lowes BA, Long CS, Bristow MR. Signaling Pathways Responsible for Fetal Gene Induction in the Failing Human Heart - Evidence for Altered Thyroid Hormone Receptor Gene Expression. Circulation103:1089-94, 2001.

• Port JD, Bristow MR. Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure. J Mol Cell Cardiol 33:887-905, 2001.

Editorial Board:

• Circulation
• Journal of Cardiac Failure
• J Molecular cellular cardiology
• J Am Coll Cardiology
• J Cardiovascular Phamacology
• Heart Failure

NIH Review Committees - Cardiovascular Study Section B, 1994-1997

My laboratory is focused on mechanisms involved in producing and reversing myocardial failure, at both the basic and clinical levels. My work is focused on the adrenergic nervous system and how its relationship to other signaling systems modifies signal transduction, myocardial function and structure, and gene expression.

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