RESEARCH INTERESTS:

• Antibodies as therapeutic agentsError! Bookmark not defined. (rattlesnake, digoxin, theophylline, tricyclic antidepressants)
• Antidotes: Their Use, Misuse and Inavailability in the United States.
• The Use of Analgesic Drugs in the Alcoholic Patient

RECENT REPRESENTATIVE RESEARCH PUBLICATIONS:

• Gomez HF, McClafferty HH, Flory D, Brent J, Dart RC. Prevention of gastrointestinal iron absorption by chelation from an orally administered deferoxamine/charcoal slurry. Ann Emerg Med 1997;30:587-592.

• Dart RC, Seifert SA, Carroll L, Clark RF, Hall E, Boyer-Hassen LV, Curry SC, Kitchens CS, Garcia RA. Affinity-purified, mixed monospecific crotalid antivenom ovine Fab for the treatment of crotalid venom poisoning. Ann Emerg Med 1997;30:33-39.

• Yip L, Dart RC, Hurlbut KM. Intravenous administration of oral N-acetylcysteine. Crit Care Med 1998;26:40-43.

• Heard K, O'Malley GF, Dart RC. Treatment of amitriptyline poisoning with bovine antibody to tricyclic antidepressants. Lancet 1999;354:1614-1615.

• Heard K, O'Malley GF, Dart RC. Antivenom Therapy in the Americas. Drugs 1999;8:5-15.

• W-F Kao, Dart RC, Kuffner E, Bogdan G. Ingestion of low concentration hydrofluoric acid: an insidious and potentially fatal poisoning. Ann Emerg Med 1999;34:35-41.

• Boyer LV, Seifert SA, Clark RF, McNally JT, Williams SR, Nordt SP, Walter FG, Dart RC. Recurrent and persistent coagulopathy following pit viper envenomation. Arch Intern Med 1999;159:706-10.

• Dart RC, Goldfrank LR, Chyka, PA, et al. Combined Evidence-Based Literature Analysis and Consensus Guidelines for Stocking of Emergency Antidotes in the United States. Ann Emerg Med 2000;36:2:126-132.

• Bogdan GM, Dart RC, Falbo SC, McNally J, Spaite D. Recurrent coagulopathy after antivenom treatment of crotalid snakebite. South Med J 2000;93:562-566.

• Dart RC, McNally JT. Efficacy, safety, and use of snake antivenoms in the United States. Ann Emerg Med. 2001;37:181-188.

RELATED ACTIVITIES:

• Assistant Editor, Annals of Emergency Medicine, 1992
• Chairman, Pharmacy and Therapeutics Committee, Denver Health Medical Center.
• Scientific Review Committee, American Association of Poison Control Centers, 1990 - present

LAY SUMMARY OF RESEARCH OBJECTIVES:

Our major focus is on the development of antidotes, particularly using antibody fragments. Our efforts led to the introduction in 2000 of a new antivenom for the treatment of rattlesnake envenomation.

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