My laboratory is involved in understanding drug metabolism of drugs used in infectious diseases. Recently we have been working on understanding the enantiomeric differences in CYP3A4 and antifungal activities of ketoconazole. In addition, we have been studying the drug-drug interaction issues with HIV protease inhibitors and other drugs used therapeutically in the HIV-infected subjects. The laboratory is also involved in the importance of plasma protein binding of drugs used in HIV infection.

UNIQUE TECHNIQUES/EQUIPMENT:

• HPLC with UV and Fluorescence detectors.
• Developing chiral assays for racemic drugs.
• In vitro drug metabolism using microsomes from cell systems expressing specific human CYP isozymes.

• Zhang X-C, Schooley RT, and Gerber JG: The effect of increasing alpha₁-acid glycoprotein concentration on the antiviral efficacy of HIV protease inhibitors. J Infec Dis 180:1833-1837, 1999.

• Gulick RM, Smeaton LM, D’Aquila RT, Eron JJ, Currier JC, Gerber JG, Acosta E, Sommadossi J-P, Tung R, Snyder S, Kuritzkes DR, and Murphy RL for the AIDS Clinical Trials Group 373 Study Team. Indinavir, Nevirapine, Stavudine and Lamivudine for HIV-Infected, Amprenavir-Experienced Subjects: AIDS CLINICAL TRIALS GROUP (ACTG) PROTOCOL 373. J Infec Dis, 183:715-21, 2001.

• Grodesky M, Acosta EP, Fujita N, Mason S, and Gerber JG. Combination Therapy with Indinavir, Ritonavir, and Delavirdine and Nucleoside Reverse Transcriptase Inhibitors in Patients with HIV/AIDS Failing Multiple Antiretroviral Combinations. HIV Clinical Trials, accepted for publication.

• Gerber JG, Rosenkranz S, Segal Y, Aberg J, D’Amico R, Mildvan D, Gulick R, Hughes V, Flexner C, Aweeka F, Hsu A, Gal J for the ACTG 401 Study Team. The effect of ritonavir/saquinavir on stereoselective pharmacokinetics of methadone: Results of ACTG 401. J of Acquired Immune Deficiency Syndromes, accepted for publication.

• Vice Chair of the AIDS CLINICAL TRIALS GROUP
• Ad hoc reviewer for:
  • Journal of Infectious Diseases
  • AIDS
  • Journal of Acquired Human Immunodeficiency Syndrome
  • DRUGS
  • Archives of Internal Medicine

I am interested in improving the safety and effectiveness of drugs that we use in the treatment of AIDS. My laboratory studies drug metabolism in people and also in the test tube. Overall goal is to avoid side effects of drugs and to maximize the effectiveness of drugs that we use in the treatment of AIDS.

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