GREGSCHWARTZ

SCHWARTZ, Gregory G., MD, PhD

Cardiology

VAMC, Room 5A-108

303-393-2826

Gregory.Schwartz@med.va.gov

RESEARCH INTERESTS:

Experimental:

Myocardial energy metabolism and its relation to ventricular function
Physiology of the right ventricle
Pharmacologic protection of ischemic myocardium
Right ventricular function and right ventricular failure in pressure overload

Clinical:

Lipid lowering in acute coronary syndromes

UNIQUE TECHNIQUES/EQUIPMENT:

Integrative assessment of myocardial energy metabolism and ventricular function in intact animal models

Measurement of tissue perfusion with microspheres

RECENT REPRESENTATIVE RESEARCH PUBLICATIONS:

Zhu P, Lu L, Xu Y, Schwartz GG. Troglitazone improves recovery of left ventricular function after regional ischemia in pigs. Circulation 2000;101:1165-1171.

Zhu P, Lu L, Xu Y, Greyson C, Schwartz GG. Glucose-insulin-potassium improves recovery of systolic and diastolic left ventricular function after low-flow ischemia in vivo. Am J Physiol 2000;278:H595-H603.

Greyson CR, Xu Y, Schwartz GG. Right ventricular free wall stress during acute pressure overload determines severity of right ventricular dysfunction following pressure overload. Am J Physiol 2000;278:H1414-H1420.

Lu L, Xu Y, Zhu P, Gunja-Smith Z, Woessner JF Jr, Galardy RE, Nissen T, Ursell P, Schwartz GG. Myocardial matrix metalloproteinases and collagen ultrastructure in low-flow ischemia and reperfusion in vivo. Am J Physiol 2000;279:H601-H609.

Lu L, Xu Y, Zhu P, Greyson CR, Schwartz GG. A common mechanism underlies concurrent changes in diastolic muscle length and systolic function in intact hearts. Am J Physiol 2001;280:H1513-H1518.

Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, Zeiher A, Chaitman BD, Stern T, Leslie S. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The MIRACL study, a randomized controlled trial. JAMA 2001;285:1711-1718.

Click here to visit PubMed for more publications by G.G. Schwartz!

RELATED ACTIVITIES:

Editorial Board, Journal of the American College of Cardiology Fellow, Council on Basic Science, American Heart Association

Cardiovascular Section, American Physiological Society

VA Merit Review Subcommittee for Cardiovascular Studies

LAY SUMMARY OF RESEARCH OBJECTIVES:
Our laboratory explores the relation between energy substrate (fuel) utilization and contractile (pumping) function of the heart. In particular, we use animal models of simulated heart attack to determine if specific drugs can help to preserve the function of the heart.
Clinical: We are exploring new and expanded applications of lipid-lowering drugs in cardiovascular disease. A recently completed international multicenter trial demonstrated that intensive lipid-lowering therapy, initiated soon after a heart attack or threatened heart attack, significantly reduces early complications including death, another heart attack, recurrent hospitalization for chest pain, or stroke.

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