WIERMAN, Margaret, MD     

 

Endocrinology, Metabolism and Diabetes     

VA 8C153A     

303-393-3137     

Margaret.Wierman@UCHSC.edu    

 

RESEARCH INTERESTS:
  • Developmental and hormonal regulation of gonadotropin releasing hormone (GnRH)
  • GnRH analogs
  • Pituitary tumors
  • Erectile dysfunction
  • Menopause

UNIQUE TECHNIQUES/EQUIPMENT:
  • Molecular genetics
  • RNA, DNA protein
  • Trangenic animals
  • DNA
  • Cell culture

RECENT REPRESENTATIVE RESEARCH PUBLICATIONS:
  • Wierman ME, Xiong X, Kepa JK, Spaulding AJ, Jacobsen BM, Fang Z, Nilaver G, Ojeda SR: Repression of gonadotropin-releasing hormone promoter activity by the POU homeodomain transcription factor SCIP/Oct-6/Tst-1: A regulatory mechanism of phenotype expression? Molecular & Cellular Biology 1997; 17:1652-1665.

  • Fang Z, Xiong X, James A, Gordon DF, Wierman ME: Identification of novel factors that regulate GnRH gene expression and neuronal migration. Endocrinology 1998; 139:3654-3657.

Click here to visit PubMed for more publications by M.E. Wierman!

LAY SUMMARY OF RESEARCH OBJECTIVES:

To understand what turns on and off the reproductive axis at the cellular level to better understand normal physiology and disorders of puberty and infertility in the male and female.

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