Faculty & Staff
Brian M. Freed, PhD - Professor of Medicine and Immunology
Division of Allergy & Clinical Immunology
Executive Director, ClinImmune Labs
4200 East Ninth Ave, B164
Denver, CO 80262
Phone: (303) 315 3187, (303) 724 0535
Fax: (303) 315 7642, (303) 724 1310
Brian.Freed@uchsc.edu
- Education:
- 1970-71 Colegio Ibitiruna, Governador Valadares, Brazil
- 1976 BA (Biology) State University of New York at Plattsburgh
- 1978 MA (Virology) State University of New York at Plattsburgh
- 1990 MS (Immunology) Albany Medical College, Albany, New York
- 1990 PhD (Immunology) Albany Medical College, Albany New York
- 1999 Diplomate, American Board of Histocompatibility and Immunogenetics
- 2006 AABB Certified Cord Blood Bank Director
- Honors, Awards and Activities:
- Member, Medical Advisory Council, The Donor Alliance
- Member, American Society for Blood and Marrow Transplantation
- Board of Directors, Juvenile Diabetes Research Foundation of Colorado
- Honorary Professor, Kunming Medical College, Kunming, Yunnan Province, China
- Department of Medicine PhD Research and Teaching Award (2007)
- Areas of Clinical Interest:
- HLA genetics in solid organ and stem cell transplantation, umbilical cord blood banking, clinical immunology
- Clinical Team:
- Michael Aubrey
- Amy Peters
- Colleen Brady
- Diana Ponce
- Sarah Bruno
- Mary Portas
- Linda Cagle
- Kristin Schultz
- Julianne DuMond
- Jennifer Settel
- Shannon Flannery
- Katharine Spanjer
- Randall Huser
- Florian Stockinger
- Kelly Lawson
- Sabine Stockinger
- Teni Lopez-Cardenas
- Linda Tapia
- Kunal Mandal
- Stephanie Warnell
- Dianne McLaughlin
- Gina Wedermyer
- Sharon Miller
- Jeanne Wischer
- Lora Offord
- Current Research Interests:
- Effects of smoking on pulmonary immune responses; HLA epitopes and immune mediated diseases.
- Research Team:
- Ashley Frazer-Abel
- Jean Harvey
- Phylicia Hermanson
- Cherie Lambert
- Christine Miller
- Min Zhang
- Recent Publications:
- McCue J, Freed BM. Measuring lymphocyte transcription factor activity by ELISA. Current Prot Toxicology 18:5.1, 2004.
- Stringer KA, Freed BM, Dunn JS, Ayers S, Gustafson DL, Flores SC. Particulate phase cigarette smoke increases MnSOD, NQO1 and Cinc-1 in rat lungs. Free Rad Biol Med 37:1527, 2004.
- Dunn JS, Freed BM, Gustafson DL, Stringer KA. Inhibition of human neutrophil reactive oxygen species production and p67phox translocation by cigarette smoke extract. Atherosclerosis 179:261, 2005.
- Lambert C, McCue J, Portas M, Ouyang Y, Li J, Rosano TG, Lazis A, Freed BM. Acrolein in cigarette smoke inhibits T cell activation. J Allergy Clin Immunology 116:916, 2005.
- Bill JR, Mack DG, Falta MT, Maier LA, Sullivan AK, Joslin FG, Martin AK, Freed BM, Kotzin BL, Fontenot AP. Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II ß chain. J Immunology 175:7029, 2005.
- Yang Y, Aubrey M, Zhang G, Ji Y, Freed BM. HLA-B*1586 is a novel hybrid HLA-H15/B22 allele with unique serology and haplotypic associations. Tissue Antigens 67:176, 2006.
- Meyer MA, Dwyer-Nield LD, Hurteau G, Keith RL, Ouyang Y, Freed BM, Kisley LR, Geraci MW, Bonventre JV, Nemenoff RA, Malkinson AM. Attenuation of the inflammatory response following butylated hydroxytoluene (BHT) treatment of cytosolic phospholipase A2 (cPLA2) null mice. Am J Physiol Lung Cell Mol Physiol 290:2160, 2006.
- Gibney EM, Cagle L, Freed B, Warnell SE, Chan L, Wiseman AC. Detection of donor-specific antibodies using HLA-coated microspheres: another tool for kidney transplant risk stratification. Nephrology Dialysis and Transplantation, 21:2625, 2006.
- Frazer-Abel A, McCue J, Lazis S, Portas M, Lambert C, Freed BM. Cigarette tar phenols impede T cell cycle progression by inhibiting cyclin-dependent kinases. Mol Immunol, 44:488, 2007.
- Recent Invited Lectures:
- Suppression of Pulmonary Immune Responses by Cigarette Smoke. University of Colorado Health Sciences Center Lung Spore Program, May 2004.
- Advances in Cord Blood Banking. National Jewish/University of Colorado Department of Immunology, September 2004.
- Marketing a Killer: The Art of Cigarette Advertising. UCHSC Arts in Medicine Lectures, November 2004.
- Smoking and Immunity. National Jewish Medical and Research Center Allergy Rounds, November 2004.
- HLA Gene Locus. National Jewish Medical and Research Center, Allergy Rounds, February 2005.
- Recent Advances in Cord Blood Transplantation. Northside Hospital, Atlanta, GA June 2005
- Recent Developments in Cord Blood Transplantation. Annual Meeting of the Association of Medical Laboratory Immunologists, Denver, 2005.
- Cord Blood Banking-A US Perspective. Brazilian National Cancer Institute, Rio de Janeiro, Brazil, October 2005.
- Administration of Cord Blood Banks for a National Network. Annual Meeting of American Association of Blood Banks (AABB), Seattle, October 2005.
- HLA and Autoimmunity. The Children's Hospital, Denver, CO, November 2005.
- Cord Blood Transplantation. Southern California Branch American Society Microbiology, November 2006.
- Fiction:
- An Adirondack Life, AuthorHouse, Bloomington, Indiana (ISBN 1587210665, May, 2000).
- See additional information about Brian Freed and ClinImmune Labs at:
- http://www.uchsc.edu/clinimmune/
Site Last Updated: 5/3/2007