Division of Allergy and Clinical Immunology
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Faculty & Staff

Cara L. Mack, MD - Assistant Professor

Primary - Department of Pediatrics, Division of Pediatric GI, Hepatology and Nutrition
Secondary - Department of Medicine, Division of Allergy & Clinical Immunology
4200 East Ninth Ave, B164
Denver, CO 80262
Phone: (303) 315 2172
Fax: (303) 315 7642
Cara.Mack@uchsc.edu

Education:
1982-86 BS (Molecular Biology) University of Wisconsin, Madison, WI
1988-92 MD (Medicine) Loyola University Stritch School of Medicine, Maywood, IL
1992-95 Pediatric Residency, University of Chicago Hospitals, Chicago, IL
1995-96 Chief Residency, University of Chicago Hospitals, Chicago, IL
1998-2001 Fellowship (Pediatric Gastroenterology) Children's Memorial Hospital, Northwestern University, Chicago, IL
Board Certification:
1995 Pediatrics
2005 Pediatric Gastroenterology
2006 Pediatric Transplant Hepatology
Areas of Clinical Interest:
Neonatal liver diseases
Autoimmune-mediated intestinal and liver disease
Pediatric liver transplantation
Clinic Location:
Pediatric Liver Clinic
The Children's Hospital
1056 E. 19th Avenue
Denver, CO 80218
Clinic Days:
Monday and Thursday mornings
Appointment Contact:
303-861-6669
Research Interests:
Dr. Cara Mack investigates biliary atresia in humans and a mouse model, examining whether the pathogenesis of biliary atresia involves a viral-induced, progressive autoimmune-mediated injury of bile ducts.
Research Team:
Rebecca Tucker, PhD
Stephen Brindley, MS
Recent Publications:
D-Y Zhang, G. Sabla, P. Shivakumar, G. Tiao, R.J. Sokol, C.L. Mack, B. Shneider, B. Aronow and J.A. Bezerra. Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia. Hepatology, 2004, Apr 39(4):954-62.
C.L. Mack, R.M.Tucker, R.J. Sokol, F.M. Karrer, B.L. Kotzin, P.F. Whitington and S.D. Miller, Biliary Atresia is Associated with CD4+ Th1 Cell-Mediated Portal Tract Inflammation, Pediatr Res. 2004 Jul;56(1):79-87.
R.J. Sokol, C.L. Mack, Optimizing outcomes and bridging biliary atresia into adulthood, Hepatology. 2005 Feb;41(2):231-3.
C.L. Mack, R.J. Sokol, Unraveling the pathogenesis and etiology of biliary atresia, Pediatr Res. 2005 May;57(5 Pt 2):87R-94R.
C.L. Mack, R.M.Tucker, R.J. Sokol, B.L. Kotzin,, Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia, Clin Immunol. 2005 May;115(2):200-9.
P.F. Whitington, P. Malladi, H. Melin-Aldana, R. Azzam, C.L. Mack, A. Sahai, Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia, Pediatr Res. 2005 Jun;57(6):837-44.
C.L. Mack, F.A. Zelko, J. Lokar, R. Superina, E.M. Alonso, A.T. Blei, P.F.Whitington, Surgically restoring portal blood flow to the liver in children with primary extrahepatic portal vein thrombosis improves fluid neurocognitive ability, Pediatrics. 2006 Mar;117(3):405-12.
J.R. Whitworth, C.L. Mack, J.A. O'Connor, M.R. Narkewicz, S. Mengshol, R.J. Sokol. Acute hepatitis and liver failure associated with influenza A infection in children. J Pediatr Gastroenterol Nutr. 2006 Oct;43(4):536-8.
C.L. Mack, R.M. Tucker, B. Lu, R.J. Sokol, A. Fontenot, R. Gill. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia, Hepatology. 2006 Nov; 44(5): 1231-1239.

Site Last Updated: 5/3/2007

Contact: Allergy & Clinical Immunology
University of Colorado at Denver and Health Sciences Center
4200 East Ninth Ave, B164
School of Medicine 4627
Denver, CO 80262
303-315-7601