Faculty & Staff

Brent E. Palmer, PhD - Assistant Professor

Division of Allergy & Clinical Immunology
Director, Flow Cytometry, ClinImmune Labs
Technical Director of the Center for AIDS Research Immunology Core
4200 East Ninth Ave, B164
Denver, CO 80262
Phone: (303) 315 0762
Fax: (303) 315 7642
Brent.Palmer@uchsc.edu

Education:
1983-1987 BS (Microbiology) Colorado State University, Fort Collins, CO
1990-1994 MS (Biology) California State University, Chico, CA
1995-1999 PhD (Immunology) Colorado State University, Fort Collins, CO
1999-2005 Post-doc, University of Colorado at Denver and HSC, Denver, CO
Research Interests:
The primary focus of my research is to delineate the mechanisms responsible for HIV-associated CD4+ T cell dysfunction. During chronic HIV infection HIV-specific CD4+ T cells are skewed toward an effector phenotype that is unable to produce IL-2 and proliferate and the loss of these cell to function has been correlated with disease severity. Most recently we have been assessing the role of protein death receptor 1 (PD-1) in the generation of HIV-specific CD4+ T cell dysfunction. I am also interested in a novel humanized mouse model of HIV infection for the study anti-HIV immunotherapeutic agents and the role of CD4+ T cells in the development of chronic beryllium disease. Lastly, as the director of the flow cytometry facility, I am steadily working on the development of novel flow-based methods for assessing the role of antigen-specific T cells in HIV and lung disease.
Honor, Award, Activities and Societies:
Honors Graduate Research Grant Award. California State University
7th and 9th Conference on Retroviruses and Opportunistic Infections Travel Award
Training Grant Award, Division of Infectious Diseases
Research Team:
Michelle D'Souza M.S.
Rebecca Peters B.S.
Recent Publications:
Palmer B.E., Boritz E., C.C. Wilson. Effects of sustained HIV-1 Plasma Viremia on HIV-1 Gag-Specific CD4+ T Cell Maturation and Function. Journal of Immunology, 172: pp. 3337-3347, March, 2004
Eli Boritz, Brent E. Palmer, and Cara C. Wilson. Proliferation-Competent, Human Immunodeficiency Virus Type 1 (HIV-1) p24 Antigen-Specific CD4+ T Cells Are Often Detected In Vitro Following CD8+ Cell Depletion and Are Associated with Lower HIV-1 Loads during Chronic, Progressive HIV-1 Infection. Journal of Virology, 78, pp 12638-12646, November, 2004
Potts G.B., Palmer B. E., Sullivan A.K. Silviera L, Maier L.A., Newman L.S., Kotzin B.L., Fontenot A.P. Frequency of beryllium-specific, TH1-type cytokine-expressing CD4+ T cells in patients with beryllium-induced disease. J. Allergy Clin Immunol. 115(5); pp1036-42, May, 2005
Andrew P. Fontenot, Brent E. Palmer, Andrew K. Sullivan, Fenneke G. Joslin, Cara C. Wilson, Lisa A. Maier, Lee S. Newman, and Brian L. Kotzin, Frequency of Beryllium-Specific, Central Memory CD4+ T Cells in Blood Determines Proliferative Response. Journal of Clinical Investigations 115 (10) pp. 2886-93 October, 2005
Palmer BE, Blyveis N, Fontenot AP, Wilson CC. Functional and Phenotypic Characterization of CD57+CD4+ T Cell and Their Association with HIV-1-Induced T Cell Dysfunction. Journal of Immunology 175 (12) pp. 8415-23 December, 2005
Simonian PL, Roark CL, Diaz del Valle F, Palmer BE, Douglas I, Ikuta K, Born WK, O'Brien RL, and. Fontenot AP. Role of Gamma delta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis. J. of Immunology 177(7) pp. 4436-43, 2006
Bradford K Berges, William H Wheat, Brent E Palmer, Elizabeth Connick and Ramesh Akkina HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gammac-/-(RAG-hu) mouse model Retrovirology 2006, 3:76 (01 Nov 2006)
Joseph Anderson, Ming-Jie Li, Brent Palmer, Leila Remling, Shirley Li, Priscilla Yam, Jiing-Kuan Yee, John Rossi, John Zaia, Ramesh Akkina. In vivo derivation of HIV-1 resistant transgenic T cells by lentiviral vector transduction of a triple combination of anti-HIV genes anti-CCR5 ribozyme, tat-rev siRNA and a TAR decoy. (In press, Molecular Therapy)
Brent E. Palmer, Douglas G. Mack, Allison K. Martin, Lisa A. Maier, and Andrew P. Fontenot. CD57 Expression Correlates with Alveolitis Severity in Subjects with Beryllium-Induced Disease (In press, Journal of Allergy and Clinical Immunology)
Lucy Golden-Mason, Brent Palmer, Jared Klarquist, John A. Mengshol, Nicole Castelblanco, Hugo R. Rosen. Upregulation of PD-1 expression on circulating and intrahepatic HCV-specific CD8+ T cells is associated with reversible immune dysfunction. (In press, Journal of Virology)
Michelle D'Souza, Andrew P. Fontenot, Doug G. Mack, Catherine Lozupone, Stephanie Dillon, Amie Meditz, Cara C. Wilson, Elizabeth Connick, Brent E. Palmer. PD-1 Expression on HIV-specific CD4+ T Cells is Driven by Viral Replication and Associated with T Cell Dysfunction (Submitted Journal of Immunology)

See additional information about Brent Palmer and ClinImmune Labs at: http://www.uchsc.edu/clinimmune/

Site Last Updated: 5/3/2007