Faculty & Staff

Philip L. Simonian, MD - Assistant Professor of Medicine

Division of Pulmonary Sciences and Critical Care Medicine
Division of Allergy and Clinical Immunology
4200 East Ninth Ave, B164
Denver, CO 80262
Phone: (303) 315 1653
Fax: (303) 315 7642
Philip.Simonian@uchsc.edu

 

Education:
1984-88 BA (Biology) University of Rochester, Rochester, NY
1990-94 MD, Northwestern University School of Medicine, Chicago, IL
1994-97 Research Fellow (Immunology) University of Michigan, Ann Arbor, MI
1997-2000 Internship/Residency (Internal Medicine) Northwestern University, Chicago, IL
2001-2004 Fellowship (Pulmonary/Critical Care) University of Colorado, Denver, CO
Board Certification:
American Board of Internal Medicine
Diplomate in Internal Medicine, 2000
Diplomate in Pulmonary Disease, 2003
Diplomate in Critical Care Medicine, 2006
Areas of Clinical Interest:
My clinical interest is the pulmonary manifestations of autoimmune diseases such as scleroderma, rheumatoid arthritis and systemic lupus erythematosus as well as pulmonary fibrosis associated with other interstitial lung diseases and acute lung injury.
Clinic Location:
University of Colorado Hospital Pulmonary Clinic
4200 East 9th Avenue and Colorado Blvd.
First floor, West Wing, Room 1124
Clinic Days:
Wednesday afternoon
Appointment Contact:
303-372-8156
Research Interests:
My research focuses on the mechanisms of inflammation and pulmonary fibrosis related to chronic exposure to inhaled antigen. The goal of our research is to identify pathogenic T cells and define the mechanisms by which they promote the development of pulmonary fibrosis.
Publications:
Simonian PL, Roark CL, Diaz del Valle F, Palmer BE, Douglas IS, Ikuta K, Born WK, O´Brien RL, Fontenot AP. Regulatory role of Υδ T cells in the recruitment of CD4+ and CD8+ to lung and subsequent pulmonary fibrosis. J Immunol 177:4436-4443, 2006
Sullivan AK, Simonian PL, Falta MT, Cosgrove GP, Brown KK, Kotzin BL, Voelkel NF, Fontenot AP. Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Am. J. Respir. Crit. Care Med. 172:590-596, 2005
Simonian PL, Grillot DA, Nunez G. Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death. Blood 90:120-1216, 1997
Simonian PL, Grillot DA, Merino R, Nunez G. Bax can antagonize Bcl-XL during chemotherapy-induced cell death independently of its heterodimerization with Bcl-XL. J Biol Chem 271:22764-22772, 1996
Simonian PL, Grillot DA, Andrews DW, Leber B, Nunez G. Bax homodimerization is not required for Bax to accelerate chemotherapy-induced cell death. J Biol Chem 271:32073-32077, 1996
Simonian PL, Grillot DA, Nunez G. Bak can accelerate chemotherapy-induced cell death independently of its heterodimerization with Bcl-XL and Bcl-2. Oncogene 15:1871-1875, 1997
Merino R, Grillot DA, Simonian PL, Muthukumar S, Fanslow WC, Bondada S, Nunez G. Modulation of anti-IgM-induced B cell apoptosis by Bcl-XL and CD40 in WEHI-231 cells: Dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction. J Immunol 155:3830-3838, 1995
Foreman KE, Wrone-Smith T, Boise LH, Thompson CB, Polverini PJ, Simonian PL, Nunez G, Nickloff BJ. Kaposi´s sarcoma tumor cells preferentially express Bcl-XL. Am J Path 149:795-803, 1996
Nunez G, Merino R, Simonian PL, Grillot DA. Regulation of lymphoid apoptosis by Bcl-2 and Bcl-XL. Adv Exp Med & Biol 406:75-82, 1996
Bojes HK, Datta K, Xu J, Chin A, Simonian P, Nunez G, Kehrer JP. Bcl-XL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal. Bichem J 325:315-319, 1997
Mitra RS, Wrone-Smith T, Simonian P, Foreman KE, Nunez G, Nickloff BJ. Apoptosis in keratinocytes is not dependent on induction of differentiation. Lab Invest 76:99-107, 1997
Raghu G, Pierre-Jerome M, Dordal MS, Simonian P, Bauer KD, Winter JN. P-glycoprotein and alterations in the glutathione/glutathione peroxidase cycle underlie doxorubicin in HL-60-R, a subclone of the HL-60 human leukemia cell line. Int J Cancer 53:804-811, 1993
George A, Sabsay B, Simonian P, Veis A. Characterization of a novel dentin matrix acidic phosphoprotein. Implications of induction of biomineralization. J Biol Chem 268:12624-12630, 1993

Site Last Updated: 5/3/2007