David C. Calverley, MD Associate Professor of Medicine and Pathology, Division of Medical Oncology Medical School: University of Alberta, Edmonton, AB, Canada University of Colorado Denver School of Medicine Division of Medical Oncology Tel: (303) 399-3888 Fax: (303) 393-5050 e-mail: david.calverley@uchsc.edu Bio Dr. Calverley has been at UCHSC and the Denver VAMC since 2001.  Research Dr. Calverley’s research focus is on platelet gene expression in metastatic lung cancer.  As a result of leaky vasculature associated with tumor blood supply, platelets are in direct contact with tumor cells and have been shown to facilitate metastasis through multiple mechanisms in vivo.  Megakaryocyte-derived platelet mRNA is capable of being translated into functional proteins in response to external stimuli, and platelet transcriptome data has been shown to correlate well with proteome data.

FACULTY LIST Lynn Bemis Virginia Borges Paul Bunn David Calverley Ross Camidge Dan Chan Gail Eckhardt Anthony Elias Thomas Flaig Marileila Garcia L. Michael Glode Rene Gonzalez Barb Helfrich Fred Hirsch Christopher Hogan Antonio Jimeno Madeleine Kane Choon-Kee Lee Stephen Leong Wells Messersmith Han Myint Ana Oton Peter Raich William Robinson Pepper Schedin John Tentler William Tse Colin Weekes

Publications
Calverley D, Baldermann L, Heldt M, Kinney G, Hokanson J. Increased platelet Fc
receptor expression in diabetes is limited to those with type 2 disease.  Atherosclerosis 2006; 185:173.

El-Shahawy M, Noureddin M, Mack W, Calverley D.  Platelet FcgammaRIIA receptor surface expression is increased in patients with end stage renal disease and is associated with atherosclerotic cardiovascular events.  Am J Kidney Dis. 2007; 49:127.

Calverley D, Thienelt C.  Platelets in Hemostasis and Thrombosis. In: Wintrobe’s  Clinical Hematology 12th ed. Lee GR et al (eds.), Lippincott,  Williams, and Wilkins, Philadelphia, PA. 2007.

PubMed articles

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