Division of Medical Oncology
University of Colorado Denver
12801 E. 17th Avenue
Aurora, CO 80010
Ph: (303) 724-3888
Fax: (303 724-3889 info@deptofmed.edu
Robert C. Doebele, M.D., Ph.D.
Assistant Professor, Division of Medical Oncology
Education:
University of Pennsylvania
Philadelphia, PA – 2001
University of Colorado Denver
School of Medicine
Division of Medical Oncology
12801 E. 17th Ave., MS 8117, Aurora, CO 80045
Tel: (303) 724-2980, Fax: (303) 724-1111
e-mail: robert.doebele@ucdenver.edu
Bio
Dr. Doebele joined the faculty at University of Colorado Denver in July of 2008 as a member of the Thoracic Malignancies Program. He completed his Internal Medicine Residency and Medical Oncology Fellowship at the University of Chicago. Following completion of his fellowship in 2007, Dr. Doebele joined the faculty of University of Chicago as an Instructor.
Research
Dr. Doebele’s laboratory is focused on basic and translational research related to lung cancer. His research has focused on the role of the Rap1 pathway, which can modulate multiple signaling pathways important for cancer cells. He has investigated the role of Rap1 in endothelial cells, where it can regulate chemotaxis and angiogenesis, a process critical to tumor growth and metastasis. Dr. Doebele will study the Rap1 pathway in lung cancer cells to understand its role in tumorigenesis, metastasis, and angiogenesis.
Publications:
Hong, J, Doebele, RC, Lingen, MW, Quilliam, LA, Tang, W , , and Rosner, MR. Anthrax Edema Toxin Inhibits Endothelial Cell Chemotaxis via Epac and Rap1. J Biol Chem, 2007. 282(27): p. 19781-7. *Co-first Authors
Doebele, RC, Pashine, A, Liu, W, Zaller, DM, Belmares, M, Busch, R, and Mellins, ED. Point mutations in or near the antigen-binding groove of HLA-DR3 implicate Class II-associated invariant chain peptide affinity as a constraint on MHC class II polymorphism. 2003. J. Immunol. 170: 4683-92.
Doebele, RC, Busch, R, Scott, HM, Pashine, A, and Mellins, ED. Determination of the HLA-DM interaction site on HLA-DR molecules. 2000. Immunity 13: 517-527.
