Christopher J. Hogan, Ph.D. Associate Professor Education:  Ph.D., Colorado State University, 1987 University of Colorado Denver School of Medicine Division of Medical Oncology Tel: (303) 724-3888 Fax: (303) 724-3115 e-mail: chris.hogan@uchsc.edu

Bio
Dr. Hogan earned his Ph.D. at Colorado State University then completed two postdoctoral fellowships, NIH & NSF, at the University of California, Berkley.  His background is in cellular, molecular, and developmental biology.  Dr. Hogan joined the faculty of Medical Oncology at University of Colorado Denver in 1994.  Although his research program involves the basic understanding of stem cells and the hematopoietic hierarchy, clinical application of findings can be translated directly to stem cell transplant strategies for cancer patients.  One immediate goal is the expansion of multipotential stem cells derived from cord blood, followed by differentiation into hematopoietic stem cells to provide enough stem cells from a cord blood unit for transplantation into adults.

Research
Dr. Hogan’s work has characterized the developmental potential in vivo of various rare populations of post-natal human stem cells, isolated from bone marrow, growth factor-mobilized peripheral blood, and umbilical cord blood, in the non-obese diabetic (NOD)/severe combined immunodeficiency (SCID) mouse model.  Using this model his lab research has defined cell populations responsible for short-term hematopoietic reconstitution, as well as populations that comprise long-term, multi-lineage repopulating elements.  Likewise, cell populations that exhibit lineage-restricted potential in vivo, as well as those that are capable of reconstituting all cell types of the hematopoietic system have been defined.