Division of Medical Oncology
University of Colorado Denver
12801 E. 17th Avenue
Aurora, CO 80010
Ph: (303) 724-3888
Fax: (303 724-3889 info@deptofmed.edu
William Tse, M.D.
Associate Professor
Director, AML/MDS Program and BMT-Hematologic Malignancies Translational Research Program
Education: Sun Yat-Sen University School of Medicine, P.R. China – 1986
University of Colorado Denver
School of Medicine
Division of Medical Oncology
Tel: 303-724-2372
Fax: 303-724-3889
Bio
Dr. William Tse joined the University of Colorado Cancer Center in March 2008 as the Director of Clinical Myelodysplastic Syndrome Program and the Director of BMT-Hematologic Malignancies Translational Research Program. He received training in Clinical Pathology at North Shore University Hospital, NYU School of Medicine; Internal Medicine at Long Island Jewish Medical Center, Albert Einstein College of Medicine; and Medical Oncology at Fred Hutchinson Cancer Research Center/University of Washington School of Medicine. Then he was recruited as Assistant Professor of Medicine at Case Western Reserve University School of Medicine, where he worked from 2004-2008
Research
Dr. Tse focuses on clinical and laboratory translational research of hematopoietic malignancies. His laboratory research is focused on leukemia biology, gene-gene collaborative leukemogenesis, leukemia stem cell signaling, prognostic biomarkers, and leukemic mouse models. His clinical research interest is focused on developing novel anti-leukemic drugs and experimental therapeutics for hematopoietic malignancies. Dr. Tse is the principle investigator on numerous national and local therapeutic clinical trials.
Publications Tse W, Zhu W, Chen HS and Cohen A.: A novel gene, AF1q, fused to MLL in t (1; 11) (q21; q23), is specifically expressed in leukemic and immature hematopoietic Cells. Blood 85:650-656, 1995 Tse W, Meshinchi S, Todd Alonzo, Appelbaum FR, Radich JP: Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukemia. Blood 104:3058-3063, 2004 Tse W, Deeg JH, Stirewalt DL, Appelbaum FR, Radich JP, Gooley T: Increased AF1q gene expression in high-risk myelodysplastic syndrome. British Journal of Hematology 128 (2):218-220; 2005
Wald D, Vermaat J, Khang Z, Roth BR, Tse W. Identification and preclinical characterization of novel Acute Myeloid Leukemia differentiation-inducing compounds 6-benzylthionine (accepted by Cancer Research).
Funding
ASCO Career Development Award
National Cancer Institute SBIR/STTR grant (P.I. David Wald, Post-doctoral Fellow in my lab)
The Multiple Myeloma Research Foundation