Doebele Lab

Main Research Focus
Dr. Doebele’s laboratory is focused on basic and translational research related to lung cancer.  His research has focused on the role of the Rap1 pathway, which can modulate multiple signaling pathways important for cancer cells.  He has investigated the role of Rap1 in endothelial cells, where it can regulate chemotaxis and angiogenesis, a process critical to tumor growth and metastasis.  Dr. Doebele will study the Rap1 pathway in lung cancer cells to understand its role in tumorigenesis, metastasis, and angiogenesis. 

Selected Publications

Hong, J*, Doebele, RC*, Lingen, MW, Quilliam, LA, Tang, W , ,  and Rosner, MR.   Anthrax Edema Toxin Inhibits Endothelial Cell Chemotaxis via Epac and Rap1.  J Biol Chem, 2007. 282(27): p. 19781-7.  *Co-first Authors

Doebele, RC, Pashine, A, Liu, W, Zaller, DM, Belmares, M, Busch, R, and Mellins, ED. Point mutations in or near the antigen-binding groove of HLA-DR3 implicate Class II-associated invariant chain peptide affinity as a constraint on MHC class II polymorphism. 2003.  J. Immunol. 170: 4683-92.

Doebele, RC, Busch, R, Scott, HM, Pashine, A, and Mellins, ED.  Determination of the HLA-DM interaction site on HLA-DR molecules.  2000.  Immunity 13: 517-527.

Lab Personnel

Robert C. Doebele, MD, PhD - Assistant Professor
Qiong Zhou, MS - PRA