Biomarker Analysis Lab

Main Research Focus:
Studies of EGFR and other biomarkers in the development and treatment of lung cancer.

Recent Publications

 1. J. Simon W. Stewart, Ezra E.W. Cohen, Lisa Licitra,Carla M.L. Van Herpen, Chonlakiet  Khorprasert,  Denis Soulieres, Pavel Vodvarka, Danny Rischin, Avgust M. Garin, Fred R. Hirsch,0 Marileila Varella-Garcia,0 Serban Ghiorghiu, Laura Hargreaves, Alison Armour, Georgina Speake, Alan Swaisland,Everett E. Vokes: A Phase III Randomized Study of Gefitinib 250 mg and 500 mg  Versus Intravenous Methotrexate for Patients With Recurrent Squamous Cell Carcinoma of the  Head and Neck. J Clin Oncol, in press.

2.  Lucio Crinò, Federico Cappuzzo, Petr Zatloukal, Martin Reck, Milos Pesek, Joyce C Thompson, Hugo ER Ford, Fred R Hirsch, Marileila Varella-Garcia, Serban Ghiorghiu, Emma L Duffield, Alison A Armour, Georgina Speake, Michael Cullen: Gefitinib Versus Vinorelbine in Chemonaïve Elderly   Patients With Advanced Non-Small-Cell Lung Cancer (INVITE): A Randomized Phase II Study. J Clin Oncol, in press.

3. Hirsch FR, Roy S. Herbst, Christine Olsen et al: Increased EGFR Gene copy number detected by FISH predicts outcome in Non-Small Cell Lung Cancer patients treated with cetuximab and chemotherapy. J Clin Oncol, in press 2008.

4. Weiss GJ, Bemis LT, Nakajima E, Sugita M, Birks DK, Robinson WA, Varella-Garcia M, Bunn PA Jr, Haney J, Helfrich BA, Kato H, Hirsch FR, Franklin WA. EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines. Ann Oncol. 2008 Feb 27

5. Zudaire E, Cuesta N, Murty VV, Woodson K, Adams L, Gomez E, Martinez A, Narayan G. Kirsch IR, Franklin WA, Hirsch FR, Birrer M, Cuttitta F. The aryl hydrocarbon receptor repressor: a new tumor suppressor gene in multiple human cancers. J Clin Invest. 2008

6. Jonsson S, Varella-Garcia M, Miller YE, Wolf HJ, Byers T, Braudrick S, Kiatsimkul P, Lewis M, Kennedy TC, Keith RL, Bjornsson J, McWilliams A, Lam S, Hirsch FR, Franklin WA. Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer. Am J Respir Crit Care Med. 2008 Feb 1;177(3):342-7.

7. Byers T, Wolf HJ, Franklin WA, Braudrick S, Merrick DT, Shroyer KR, Hirsch FR, Zeng C, Barón AE, Bunn PA, Miller YE, Kennedy TC. Sputum cytologic atypia predicts incident lung cancer: defining latency and histologic specificity. Cancer Epidemiol Biomarkers Prev. 2008 Jan

8. Hirsch FR, Dziadziuszko R, Thatcher N et al. Epidermal growth factor receptor immunohistochemistry: comparison of antibodies and cut-off points to predict benefit from Gefitinib in a phase III placebo-controlled study in advanced non-small cell lung cancer. Cancer, 112:1114-1122.  2008.

Lab Personnel

Fred R Hirsch MD PhD - PI
Norma Aumen BS, HTL (ASCP) - Lab Manager, histologist
Ilya Igolnikov BA - PRA, clinical coordinator
Samir Witta MD PhD - Fellow
Anna Spreafico MD - Fellow
Veronika Franekova-Stefanikova, PhD - Fellow
Koichi Yoshida MD PhD - Fellow