Research in our laboratory focuses on the actions of women's ovarian hormones, estradiol and progesterone, and their role in breast cancer. These hormones activate intranuclear receptors that regulate gene transcription. In breast cancers, estrogen (ER) and progesterone (PR) receptors control tumor development and growth, they are markers of hormone dependence and tumor aggressiveness, and they are targets for treatments with antiestrogens, aromatase inhibitors and progestins. The lab consists of approximately 15 collaborating investigators with appointments as junior faculty, postdoctoral and clinical fellows, graduate and medical students, and research assistants. The research in breast cancer ranges from basic molecular biology of receptor action in transcription, to cell and tumor biology, role of hormones in metastasis, and translational studies. Please enjoy the site and feel free to contact us with questions or comments.