| Lab Publications |
| Harrell
JC, Dye WW, Allred DC, Jedlicka P,
Spoelstra NS,
Sartorius CA, Horwitz KB Estrogen receptor positive breast cancer metastasis: altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes. Cancer Research 2006, 66(18):9308-15. PubMed Link |
| Jacobsen BM, Harrell
JC, Jedlicka P, Borges VF,
Varella-Garcia M, Horwitz KB Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium. Cancer Research 2006, 66(16):8274-9. PubMed Link |
| Tung L, Abdel-Hafiz H,
Shen T, Harvell DM, Nitao LK,
Richer JK, Sartorius CA, Takimoto GS, Horwitz KB Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B. Molecular Endocrinology 2006, 20(11):2656-70. PubMed Link |
| Ghatge RP, Jacobsen BM, Schittone SA, Horwitz KB The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells. Breast Cancer Research 2005, 7(6):R1036-50. |
| Sartorius CA, Harvell
DM, Shen T, Horwitz KB Progestins initiate a luminal to myoepithelial switch in estrogen-dependent human breast tumors without altering growth. Cancer Research 2005, 65(21):9779-88. PubMed Link |
| Harvell
DM, Richer JK, Allred DC, Sartorius CA, Horwitz KB Estradiol regulates different genes in human breast tumor xenografts compared with the identical cells in culture. Endocrinology 2006, 147(2):700-13. PubMed Link |
| Jacobsen BM, Schittone SA, Richer
JK, Horwitz KB Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biology. Molecular Endocrinology 2005, 19(3):574-87. PubMed Link |
| Jacobsen BM, Richer JK, Sartorius CA, Horwitz KB Expression profiling of human breast cancers and gene regulation by progesterone receptors. Journal of Mammary Gland Biology and Neoplasia 2003, 8(3):257-68. PubMed Link |
| Takimoto GS, Tung L,
Abdel-Hafiz H, Abel MG, Sartorius CA,
Richer JK, Jacobsen BM, Bain DL, Horwitz KB Functional properties of the N-terminal region of progesterone receptors and their mechanistic relationship to structure. Journal of Steroid Biochemistry and Molecular Biology 2003, 85(2-5):209-19. PubMed Link |
| Sartorius
CA, Shen T,
Horwitz KB Progesterone receptors A and B differentially affect the growth of estrogen-dependent human breast tumor xenografts. Breast Cancer Research and Treatment 2000, 79(3):287-99. PubMed Link |
| Abdel-Hafiz H, Takimoto GS, Tung L, Horwitz KB The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepression. Journal of Biological Chemistry 2002, 277(37):33950-6. PubMed Link |
| Jacobsen BM, Richer JK,
Schittone SA, Horwitz KB New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulation. Journal of Biological Chemistry 2002, 277(31):27793-800. PubMed Link |
| Richer JK, Jacobsen BM, Manning NG, Abel MG, Wolf DM, Horwitz
KB Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. Journal of Biological Chemistry 2002, 277(7):5209-18. PubMed Link |
| Tung
L, Shen T, Abel MG, Powell RL, Takimoto GS, Sartorius
CA, Horwitz KB Mapping the unique activation function 3 in the progesterone B-receptor upstream segment. Two LXXLL motifs and a tryptophan residue are required for activity. Journal of Biological Chemistry 2001, 276(43):39843-51. PubMed Link |
| Bain
DL,
Franden MA, McManaman JL, Takimoto GS, Horwitz KB The N-terminal region of human progesterone B-receptors: biophysical and biochemical comparison to A-receptors. Journal of Biological Chemistry 2001, 276(26):23825-31. PubMed Link |
| Graham JD, Bain DL, Richer JK,
Jackson TA, Tung L, Horwitz KB Thoughts on tamoxifen resistant breast cancer. Are coregulators the answer or just a red herring? Journal of Steroid Biochemistry and Molecular Biology 2000, 74(5):255-9. PubMed Link |
| Graham JD, Bain DL, Richer JK, Jackson TA, Tung L, Horwitz KB Nuclear receptor conformation, coregulators, and tamoxifen-resistant breast cancer. Steroids 2000, 65(10-11):579-84. PubMed Link |
| Sartorius CA, Takimoto GS, Richer
JK, Tung L, Horwitz KB Association of the Ku autoantigen/DNA-dependent protein kinase holoenzyme and poly(ADP-ribose) polymerase with the DNA binding domain of progesterone receptors. Journal of Molecular Endocrinology 2000, 24(2):165-82. PubMed Link |
| Bain DL, Franden MA, McManaman JL, Takimoto GS,
Horwitz KB The N-terminal region of the human progesterone A-receptor. Structural analysis and the influence of the DNA binding domain. Journal of Biological Chemistry. 2000, 275(10):7313-20. PubMed Link |
| Lange CA, Shen T, Horwitz KB Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. Proceedings of the National Acadademy of Sciences U.S.A. 2000, 97(3):1032-7. PubMed Link |