Paul S. MacLean, Ph.D.  Associate Professor of Medicine

Dr. MacLean joined the UCD faculty in 2001 after receiving his research education and training at Brigham Young and East Carolina Universities. His research efforts are focused on understanding the metabolic contribution to the obesity epidemic. He is funded by the National Institutes of Health to examine the metabolic adaptations to long term weight reduction that promote weight regain and strategies that facilitate weight loss by countering those adaptations.  He collaborates with several members of the Center for Human Nutrition and the IMAGE Group (Investigations in Metabolism, Aging, Gender and Exercise) on NIH-funded clinical and preclinical projects studying metabolic questions in obesity and exercise.  He is also working with members of the University of Colorado Cancer Center to examine the link between obesity and breast cancer with funding from the Komen foundation.  Dr. MacLean is the Research Director within the Division, and serves as the Associate Director of both the Metabolic Core Laboratory and the Energy Balance Core Laboratory, which are affiliated with the Colorado Clinical Nutrition Research Unit. 

Selected Publications

• Jackman MR, Steig A, Higgins JA, Johnson GC, Fleming-Elder BK, Bessesen DH, MacLean PS.  Weight Regain After Sustained Weight Reduction is Accompanied by Suppressed Oxidation of Dietary Fat and Adipocyte Hyperplasia. Am J Physiol Regul Integr Comp Physiol  294: R1117-R1129, 2008. PUBMED
• Jackman MR, Kramer RE, MacLean PS, Bessesen DH. Trafficking of dietary fat in obesity-prone and obesity-resistant rats. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1083-91. PUBMED
   
• MacLean PS, Higgins JA, Jackman M, Johnson GC, Fleming-Elder BK, Wyatt H, Melanson EL, Hill JO. Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol 290:1577-1588, 2006. PUBMED
   
• Qiao L, MacLean PS, You H, Schaack J, Shao J. Knocking down liver C/EBPα by adenovirus-transduced siRNA improves hepatic gluconeogenesis and lipid homeostasis in db/db mice. Endocrinology 147(6):3060-3069, 2006. PUBMED
   
• MacLean PS, Jackman M, Bessesen DH. Compensatory Response to Reducing Weight. Drug Discovery Today: Disease Mechanisms 2(3):313-319, 2005.
• Qiao L, MacLean PS, Schaack J, Orlicky DJ, Darimont C, Pagliassotti MJ, Friedman JE, Shao J. C/EBPα regulates human adiponectin gene transcription through an intronic enhancer. Diabetes 54(6): 1744-1754, 2005. PUBMED
• MacLean PS, Vadlamudi S, MacDonald KG, Pories WJ, Barakat HA. Suppression of hepatic CETP expression in obese humans with the development of type 2 diabetes mellitus. J Clin Endo Metab 90, 2250-8, 2005. PUBMED

Last updated: October 14, 2008