Paul S. MacLean, Ph.D.  Associate Professor of Medicine

Dr. MacLean joined the UCDHSC faculty in 2001 after receiving his research education and training at Brigham Young and East Carolina Universities. His research efforts are focused on understanding the metabolic contribution to the obesity epidemic. He is funded by the National Institutes of Health to examine the metabolic adaptations to long term weight reduction that promote weight regain (DK038088) and the use of ingested tracers and adenoviral gene delivery to study skeletal muscle metabolism (DK067403).  Dr. MacLean also has funding from General Mills and Kraft foods that examine the effects of certain types of macronutrients on whole body and tissue-specific fuel metabolism.  In addition to these pursuits, he is actively engaged with a number of collaborators in the UCDHSC Center for Human Nutrition and the IMAGE Group (Investigations in Metabolism, Aging, Gender and Exercise).  Within the University, Dr. MacLean is the Associate Director of both the Metabolic Core Laboratory and the Energy Balance Core Laboratory that are affiliated with the Colorado Clinical Nutrition Research Unit (P30 DK48520).

Selected Publications

• Jackman MR, Kramer RE, MacLean PS, Bessesen DH. Trafficking of dietary fat in obesity-prone and obesity-resistant rats. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1083-91. PUBMED
   
• MacLean PS, Higgins JA, Jackman M, Johnson GC, Fleming-Elder BK, Wyatt H, Melanson EL, Hill JO. Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol 290:1577-1588, 2006. PUBMED
   
• Qiao L, MacLean PS, You H, Schaack J, Shao J. Knocking down liver C/EBPα by adenovirus-transduced siRNA improves hepatic gluconeogenesis and lipid homeostasis in db/db mice. Endocrinology 147(6):3060-3069, 2006. PUBMED
   
• MacLean PS, Jackman M, Bessesen DH. Compensatory Response to Reducing Weight. Drug Discovery Today: Disease Mechanisms 2(3):313-319, 2005.
   
• Qiao L, MacLean PS, Schaack J, Orlicky DJ, Darimont C, Pagliassotti MJ, Friedman JE, Shao J. C/EBPα regulates human adiponectin gene transcription through an intronic enhancer. Diabetes 54(6): 1744-1754, 2005. PUBMED
   
• MacLean PS. A peripheral perspective of weight regain. Am J Physiol Regul Integr Comp Physiol 288:1447-9, 2005. PUBMED
   
• MacLean PS, Vadlamudi S, MacDonald KG, Pories WJ, Barakat HA. Suppression of hepatic CETP expression in obese humans with the development of type 2 diabetes mellitus. J Clin Endo Metab 90, 2250-8, 2005. PUBMED

Last updated: March 26, 2007