Subjects needed for an exercise metabolism research study

Are you an individual with Type 2 diabetes or a sedentary man or woman age 30-50 and interested in being involved in a research project? We are looking for volunteers to participate in a metabolism study investigating how fat stored in your muscle affects insulin activity. The

Individuals that participate receive comprehensive metabolic testing, a custom diet, body composition analysis, measurement of metabolic rate, and insulin sensitivity. Compensation is provided for your time and participants receive all results from the study.

Two different preliminary assessments will measure your:

• body fat content
• maximal exercise capacity (VO2max)
• heart rhythm
• resting metabolic rate
• glucose tolerance
• blood tests
• health and physical examination performed by a physician

Volunteers will complete one metabolic study day following a 12 hour fast, where you will lie quietly for 4 hours, exercise for 1.5 hours at an easy to moderate intensity (50% of maximal capacity), and lie quietly again after exercise for 2 hours. All 3 visits will be performed at the General Clinical Research Center in Denver.

For the metabolic study day, the following will occur:

• Diet will be controlled for 3 days before each study day
• During the study day:
• Infusion of naturally occurring tracer of carbohydrate and fat through an intravenous catheter
• Blood sampling from a catheter placed in a hand vein
• 3 muscle biopsies
• 1.5 hours of exercise at 45% of maximal capacity

Compensation will be provided.
P.I. Dr. Bryan Bergman, COMIRB # 03-398, revised 3/30/05

Please call Devon at 303-724-3968 for more information about this study.