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Leigh Perreault, MD, Assistant Professor of Medicine

Dr. Leigh Perreault is a physician and clinical researcher at the University of Colorado Denver School of Medicine, Aurora, CO. Her overarching research interest lies in understanding the different pathways by which people develop type 2 diabetes, and developing tailored strategies for diabetes prevention. Research projects to date have yielded valuable information about sex differences in diabetes risk, and most notably, key metabolic features in people with different types of pre-diabetes (impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and IFG/IGT), that may prove useful targets for diabetes prevention in these groups. In pursuit of her research interests, Dr. Perreault works closely with the Diabetes Prevention Program (DPP) and heavily utilizes the Clinical Translational Research Center (CTRC) on campus.

Dr. Perreault graduated from the University of Southern California Keck School of Medicine in 1996. She completed a residency in Internal Medicine and fellowship in Endocrinology, Metabolism and Diabetes at the University of Colorado Denver School of Medicine, and is currently board-certified in both. Dr. Perreault has received an Endocrine Fellow's Foundation Award, Patient-oriented Career Development Award (K23) from the National Institutes of Health, as well as a Career Development Award from the American Diabetes Association, for her work unraveling the metabolic complexities of pre-diabetes. She works tirelessly on behalf of people at risk for diabetes, both as the Vice Chair for the American Diabetes Association's EXPO in Colorado, and also spearheading a novel clinical care approach for people with pre-diabetes.

Selected Publications

  • Perreault L, Hunerdosse DM, Bergman BC. Divergent effects of sitagliptin in obese people with and without impaired fasting glucose. Diabetes Care , in review 2008.
  • Perreault L, Bergman BC, Hunerdosse DM, Playdon MC, Eckel RH. Inflexibility in intramuscular triglyceride fractional synthesis rate distinguishes pre-diabetes from obesity in humans. Diabetes, in press 2008.
  • Bergman BC, Perreault L, Koehler MC, Samek AM, Eckel RH, The athlete's paradox: alterations in intramuscular lipid turnover and diacylglycerol saturation influence insulin action. Diabetologia, in review 2008.
  • Perreault L, Bergman BC, Playdon MC, Dall Man C, Cobelli C, Eckel RH. Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of pre-diabetes? Am J Physiol Endocrinol Metab 295: E428-435, 2008. PUBMED
  • Perreault, L, Ma, Y, Dagogo-Jack, S, Horton, E, Marrero , D, Crandall, J, Barrett-Connor, E. Sex differences in diabetes risk and the effect of intensive lifestyle modification in the Diabetes Prevention Program. Diab Care, 31:1-6, 2008. PUBMED
  • Perreault L, Lavely JM, Bergman BC , Horton TJ. Gender differences in insulin action following a single bout of exercise. J Appl Physiol 97: 1013-1021, 2004. PUBMED
  • Perreault L, Lavely J, Horton TJ. Gender differences in lipoprotein lipase activity following acute exercise. Obes Res, 12:241-249, March 2004. PUBMED
  • Dean T, Perreault L, Mazzeo RS, Horton TJ. No effect of menstrual cycle phase on lactate threshold. J Appl Physiol, 95: 2537-2543, 2003. PUBMED