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Faculty Profile

Subbiah Pugazhenthi, Ph.D.,  Assistant Professor of Medicine

The focus of Dr. Pugazhenthi's research is “Transcriptional regulation of cytoprotective genes in pancreatic beta cells and hippocampal neurons”. He is interested in understanding the molecular mechanism of beta cell apoptosis in diabetes and neuronal dysfunction in Alzheimer’s disease. Studies are being carried out to examine the regulation of gene expression using cell culture and animal models. Strategies are being developed for viral vector mediated gene transfer in vitro and in vivo. The long-term goal is to enhance cell survival through modulation of transcription factors under conditions of stress.

 

Selected Publications

  • Pugazhenthi S, Phansalkar K, Audesirk G, West A, and Cabell L. Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal. Free Radical Biology and Medicine 40, 21-34, 2006. PUBMED

  • Sze CI, Su M, Pugazhenthi S, Jambal P, Hsu LJ, Heath J, Schultz L and Chang NS. Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease. J Biol Chem 279, 30498-506, 2004 PUBMED

  • Vaishnav D, Jambal P, Reusch E-B J, and Pugazhenthi S: SP600125, an inhibitor of c-jun N- terminal kinase activates CREB by a p38 MAPK-kinase pathway. Biochem. Biopsy. Res. Commun. 307, 855-860, 2003. PUBMED

  • Jambal P, Masterson S, Nesterova A, Bouchard R, Bergman B, Hutton JC, Boxer LM, Reusch J E-B and Pugazhenthi S. Cytokine-mediated downregulation of the transcription factor cAMP- response element- binding protein in pancreatic b-cells. J Biol Chem 278, 23055-23065, 2003. PUBMED

  • Pugazhenthi S, Nesterova A, Purevsuran J, Audesirk G, Kern M, Cabell L, Eves E, Rosner MR, Boxer LM, and Reusch J E-B. Oxidative stress mediated downregulation of bcl-2 promoter in hippocampal neurons. J Neurochem 84, 982-996, 2003, PUBMED

  • Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE and Reusch J E-B: Akt/Protein kinase B up-regulates Bcl-2 expression through cAMP response element binding protein. J Biol Chem 275, 10761-10766, 2000. PUBMED