| Our laboratory uses reoviruses as an experimental model system to understand how discrete viral genes and the proteins they encode determine the capacity of viruses to produce disease and cellular injury. A major focus of our laboratory has been in the area of virus-induced apoptosis. We have recently shown that reoviruses can induce apoptosis both in vitro and in vivo, and that reovirus strains can differ in this capacity. Studies currently underway include: the subcellular localization of reovirus nonstructural protein sigma 1 small and its role in reovirus infection, gene chip/microarray studies of reovirus infected cells, reovirus encephalitis and neuronal apoptosis, reovirus myocarditis and myocardiocyte apoptosis, cellular mechanisms of reovirus-induced apoptosis, and reovirus as a cancer therapeutic. |
| Ken Tyler,
MD: Professor, Primary Investigator Penny Clarke, PhD: Assistant Professor Roberta DeBiasi, MD: Assistant Professor Rob Goody, PhD: Postdoctoral Fellow Cristen Hoyt, BS: Graduate Student, Immunology Sarah Richardson-Burns, BS: Graduate Student, Neuroscience Suzanne Meintzer, BS: Professional Research Assistant / Laboratory Manager Bridget Robinson, MS: Professional Research Assistant |
