Martin Reite, M.D.
(303) 315-5364
Martin.Reite@UCHSC.eduDr. Reite's current research efforts are concentrated in the area of developing new metrics for assessment of brain functional and structural correlates of abnormal human behavior, with an emphasis on the major mental disorders. These strategies emphasize magnetoencephalography (MEG) and magnetic source imaging (MSI) and magnetic resonance imaging (MRI). Opportunities also exist to work in EEG-based brain electrical activity mapping (BEAM, or QEEG), and EEG-based evoked potential (EP) source analysis.
Scientific questions address evidence of anomalous lateralization of the brain in individuals with psychotic disorders, impaired short term memory function in psychosis, and studies of sensory cortical reorganization accompanying psychosis. Efforts are underway to determine whether these abnormalities represent developmental pathologies predisposing to psychosis, or are the result of psychotic thinking or its treatment.
Subject populations in currently funded studies include normal adolescents and adults, adolescents and adults with psychotic disorders or other psychopathology, and subjects with developmental disabilities such as autism.
MEG recordings in the Biomagnetic Imaging Laboratory utilize a Magnes 3600 248 channel whole head system to record the extracranial magnetic fields produced by deep intraneuronal brain current sources, and a variety of software to estimate the 3-Dd location of brain regions producing that activity. MSI permits the 3-D localization of these deep sources with an accuracy of several millimeters. MR imaging of the brain permits co-registration of magnetic activity with discrete neuroanatomical sources. Volumetric determinations of specific neuroanatomic structures facilitates correlation of function with structure. EEG, QEEG, and EP data provide estimates of extraneuronal current flows associated with specific sensory and cognitive processing, which can be correlated with MEG and MR measures.
MEG, with high resolution in both temporal and spatial domains, permits as well localization and physiological quantification of early memory processes, including the echoic trace, and working memory storage, scanning, and retrieval.
The long term goal of this research is to utilize newly developing brain functional and structural assessment techniques to improve our understanding of both normal and abnormal human brain function, especially in individuals with psychotic disorders and developmental disabilities.
For additional details of these techniques and findings, please refer to the accompanying publication summaries or visit the Biomagnetic Imaging Laboratory’s home page at www.neuromeg.org.
Recent Publications:1. Reite, M., Sheeder, J., Teale, P., Adams, M., Richardson, D., Simon, J., Rojas. D.C. (1997). Magnetic source imaging evidence of sex differences in cerebral lateralization in schizophrenia. Arch. Gen. Psychiat., 54: 433-440.2. Rojas, D.C., Teale, P., Sheeder, J., Simon, J., Reite, M. (1997). Sex-specific expression of Heschl’s gyrus functional and structural changes in paranoid schizophrenia. Am. J. Psychiat., 154: 1655-1662.
3. Reite, M., Teale, P., Rojas, D.C. Magnetoencephalography: Applications in psychiatry. Biol. Psych. 45(12): 1564-1571, 1999.
4. Reite, M., Teale, P., Rojas, D.C., Arciniegas, D., Sheeder, J. Bipolar disorder: Anomalous brain asymmetry associated with psychosis. Am. J. Psychiatry 156(8): 1159-1163, 1999.
5. Reite, M.L., Teale, P.D., Rojas, D.C., Sheeder, J., Arciniegas, D. Schizoaffective disorder: Evidence for reversed cerebral asymmetry. Biol. Psychiat., 156(8):1159-1163, 1999.
6. Teale, P.T., Reite, M.L. Rojas, D.C., Sheeder, J., Arciniegas, D. Fine structure of the auditory M100 in schizophrenia and schizoaffective disorder. Biol. Psychiat. 48(11):1109-1112, 2000.
7. Reite, M., Teale, P., Rojas, D., Benkers, T., Carlson, J.. Anomalous somatosensory cortical localization in schizophrenia. Am. J. Psychiat. 160(12):2148-2153 , 2003.
POSTDOCTORAL RESEARCH TRAINING PROGRAM IN DEVELOPMENTAL PSYCHOBIOLOGYDepartment of Psychiatry
University of Colorado Denver
Denver, CO 80262For additional Information E-mail:
Martin.Reite@UCHSC.edu
If you have any comments or suggestions, feel free to E-mail:
Linda.Greco-Sanders@UCHSC.edu
