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Division of Radiation and Cancer Biology

Overview:
The Division of Radiation and Cancer Biology is the basic research arm of the Department of Radiation Oncology at UCHSC.  Its missions are:

  • To carry out original basic and translational research of relevance to cancer therapy;
  • To provide educational and training opportunities to radiation oncology residents so that they fulfill their potential to become future leaders in academic radiation oncology;
  • To train graduate students and postdoctoral fellows to become proficient researchers in the field of radiation and cancer biology;
  • To provide clinicians with a platform to solve clinical questions through laboratory research and to rapidly translate new laboratory discoveries into clinical treatment for patients with cancer.

    Faculty Research Interests

    Chuan-Yuan Li, Ph.D. is Professor and Director of the Division of Radiation and Cancer Biology. He joined UCHSC in the summer of 2006 from Duke University Medical Center, where he was a professor of radiation oncology and cancer biology. Research in his laboratory is focused on the following areas:

    • Molecular mechanisms of tumor microenvironmental response to radiation and chemotherapy.
    • Molecular Imaging approaches to study in vivo cancer signal transduction.
    • Novel gene/immunotherapy approaches to enhance conventional cancer therapy.
    • Mechanistic investigations of radiation-induced mutagenesis and carcinogenesis.

    For more details please see Dr. Li’s CV.

    Barbara Frederick, Ph.D. is an assistant professor in the Division of Radiation and Cancer Biology. Her research interests are:

    • Developing biomarkers to predict patient response to targeted agents and radiation therapy
    • Sequencing combinations of targeted agents and radiation
    • Induction of miRNAs by radiation
    • Epigenetic events that drive tumor progression

    Fang Li, Ph.D. is an Instructor in the Division of Radiation and Cancer Biology. She has been working together with Dr. Chuan-Yuan Li since 2003. Her main research interest is on the roles of HIF genes (HIF-1 and HIF-2) in tumor response to radiotherapy.

    David Raben, M.D. is an associate professor of Radiation Oncology and has worked primarily on new drugs that interfere with specific parts of the cancer cell signaling process to enhance radiation therapy. His focus has been on patients with locally advanced head and neck cancer, lung cancer and pancreatic cancer. He is a principal investigator on multiple clinical trials that have brought some of these new drugs into the clinical arena on both a local and national level.

    Brian Kavanagh, MD is an associate professor of Radiation Oncology. He has been involved in a number of clinical-translational projects including studies on the application of efaproxiral as an enhancer of radiotherapy, investigations of the clinical and biological effects of stereotactic body radiation therapy, and early phase clinical trials involving the combination of radiation therapy with new systemic agents.”

    Education and Training Opportunities.
    We provide research and training opportunities to the following categories of students:

    • Residents who are interested in various short to mid-term (4-12 months) research projects.
    • Postdoctoral research fellows supported by federal or industry grants or fellowships.
    • Graduate students enrolled in various UCHSC graduate study programs.
    • Summer research opportunities for medical students and undergraduate students.

    Course offered: The Biological Basis of Radiotherapy, open to residents, postdoctoral fellows, and graduate students. Please get in touch with Dr. Chuan-Yuan Li for course information.

    Location: RC-1 south, 4th floor.

    Contact information:
    Dr. Chuan-Yuan Li
    Tel: (303) 724-1542
    Email: Chuan.Li@uchsc.edu                                                                                                                   
    Dr. Barbra Frederick
    Tel: (303) 724-3027           
    Email: Barbra.Fredrick@uchsc.edu

    Dr. Fang Li
    Tel: (303) 724-1625
    Email: Fang.Li@uchsc.edu

    Dr. David Raben
    Tel : (720)-848-0116
    Email : David.Raben@uchsc.edu

    Brian D. Kavanagh, MD, MPH
    Tel: 720-848-0156
    Email: Brian.Kavanagh@uchsc.edu