Quality Inn (618) 549-4244
1415 E Main St, Carbondale, IL 62901

Best Inns of America (618) 529-4801
1345 E Main St, Carbondale, IL 62901

Days Inn (618) 457-3347
801 E Main St, Carbondale, IL 62901

Ramada Inn (618) 351-6611
801 N Giant City Rd, Carbondale, IL 62901

Motel 6 (618) 457-5566
700 E Main St, Carbondale, IL 62901

Super 8 Motel (618) 457-8822
1180 E Main St, Carbondale, IL 62901

Giant City Lodge
460 Giant City Lodge Road
Makanda, IL 62958
http://dnr.state.il.us/lodges/gc.htm

Note that this is not an exhaustive listing of hotels in Carbondale.