• Agarwal, Rajesh, Ph.D.
• Anchordoquy, Thomas J., Ph.D.
• Anderson, Peter, Pharm.D.
• Aquilante, Christina, Pharm.D.
• Bain, David L., Ph.D.
• Carpenter, John, Ph.D.
• Franklin, Christopher, Ph.D.
• Hail, Jr., Numsen, Ph.D.
• Irons, Richard D., Ph.D.
• Jones Braun, LaToya, Ph.D.
• Ju, Cynthia, Ph.D.
• Kiser, Jennifer, Pharm.D.
• Kompella Uday B., PhD
• Malkinson, Alvin M., Ph.D.
• Mallela, Krishna M. G., Ph.D.
• Maluf, N. Karl, Ph.D.
• Patel, Manisha, Ph.D.
• Petersen, Dennis R., Ph.D.
• Radcliffe, Richard, Ph.D.
• Ross, David, Ph.D.
• Ruth, James. A., Ph.D.
• Scheinman, Robert I., Ph.D.
• Thompson, John A., Ph.D.
• Vasiliou, Vasilis, Ph.D.

Rajesh Agarwal, Ph.D.

Professor, Department of Pharmaceutical Sciences

Mailing address:
4200 E. 9th Ave, C238
Denver, CO 80262

Telephone:
Voice:     303-315-1381
Lab :       303-315-1227
Fax:        303-315-6281
E-Mail: Rajesh.Agarwal@UCHSC.EDU

Training and Education:
B.S. (1975)-Chemistry, Biology - Lucknow University, India
M.S. (1977)-Organic Chemistry - Lucknow University, India
Ph.D. (1981) Bio-Organic Chemistry - Lucknow University, India

Research Interest:
    ·      Prevention and Therapy of cancer: Dietary and synthetic agents - cellular, biochemical and molecular mechanisms employing biochemical and molecular
biological techniques.  Evaluation of cancer chemopreventive potential of dietary constituents employing several long-term animal tumor bioassay protocols, and short-term animal and cell culture assays.  Models include skin, prostate, colon, bladder, ovarian and lung cancers.
    ·      Mechanism of cancer prevention and therapy: Oncogenes and suppressor genes, cell cycle modulation, p53, cyclins, cyclin dependent kinases, cyclin dependent kinase inhibitors, apoptosis, and mitogenic and anti-apoptotic signaling pathways.
   ·      Carcinogenesis - causation and mechanistic studies employing enzyme bioassay and molecular biology approaches, cell culture technique and long-term animal tumor studies.
   

Representative Publications: 
Varghese, L., Agarwal, C., Tyagi, A., Singh, R.P. and Agarwal, R.: Silibinin efficacy against human hepatocellular carcinoma. Clin. Cancer Res., 11: 8441-8448, 2005.
Deep, G., Singh, R.P., Agarwal, C., Kroll, D.J. and Agarwal, R.: Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene, 25: 1053-1069, 2006.
Singh, R.P., Dhanalakshmi, S., Mohan, S., Agarwal, C. and Agarwal, R.: Silibinin inhibits UVB- and EGF-induced mitogenic and cell survival signaling involving AP-1 and NF-κB in mouse epidermal JB6 cells. Mol. Cancer Therapeutics, 5: 1145-1153, 2006.
Singh, R.P., Deep, G., Chittezhath, M., Kaur, M., Dwyer-Nield, L.D., Malkinson, A.M. and Agarwal, R.: Effect of silibinin on the growth and progression of primary lung tumors in mice. J. Natl. Cancer Inst., 98: 845-855, 2006.
Tyagi, A., Singh, R. P., Agarwal, C. and Agarwal, R.: Silibinin activates p53-caspase-2 pathway and causes caspase-mediated cleavage of cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: an evidence for a regulatory loop between p53 and caspase-2. Carcinogenesis, Advance Access published online on June 15th, 2006

Curriculum Vitae
Recent Publications

Keywords:
Cancer chemoprevention, phytochemicals, skin cancer, prostate cancer, silibinin, silymarin, grape seed extract, phytic acid, IP6.

Last updated: 2/28/08