• Agarwal, Rajesh, Ph.D.
• Anchordoquy, Thomas J., Ph.D.
• Anderson, Peter, Pharm.D.
• Aquilante, Christina, Pharm.D.
• Bain, David L., Ph.D.
• Carpenter, John, Ph.D.
• Franklin, Christopher, Ph.D.
• Hail, Jr., Numsen, Ph.D.
• Irons, Richard D., Ph.D.
• Jones Braun, LaToya, Ph.D.
• Ju, Cynthia, Ph.D.
• Kiser, Jennifer, Pharm.D.
• Kompella Uday B., PhD
• Malkinson, Alvin M., Ph.D.
• Mallela, Krishna M. G., Ph.D.
• Maluf, N. Karl, Ph.D.
• Patel, Manisha, Ph.D.
• Petersen, Dennis R., Ph.D.
• Radcliffe, Richard, Ph.D.
• Ross, David, Ph.D.
• Ruth, James. A., Ph.D.
• Scheinman, Robert I., Ph.D.
• Thompson, John A., Ph.D.
• Vasiliou, Vasilis, Ph.D.

Richard D. Irons, Ph.D.

Professor of Toxicology, Department of Pharmaceutical Sciences

Mailing address:
4200 E. 9th Ave, C238
Denver, CO 80262

Telephone:
Voice:     303-315-7196
Lab:        303-315-7170/7209
Fax:        303-315-7223
E-Mail:   Richard.Irons@uchsc.edu 

Affiliations:
Professor of Pathology, University of Colorado School of Medicine.
Program Leader, University of Colorado Cancer Center.

Training and Education:
B.A., Raymond College, University of the Pacific (Chemistry, Lib. Arts., Political Science)
M.T., San Joaquin Gen. Hospital, University of California
Ph.D., University of Rochester School of Medicine and Dentistry (Toxicology)

Research Interests:
Research in Dr. Irons' laboratory focuses on understanding the pathogenesis of diseases of the blood and the immune system and mechanisms of drug and chemical toxicity.  He is also director of the Sino-US Joint Clinical and Molecular Laboratory (JCML) which is  a state-of-the-art clinical and molecular research facility that uses medical technology not routinely available in China, to support the diagnosis and management of patients with hematopoietic and lymphoid diseases at over 30 hospitals in Shanghai.  In order to do this, JCML integrates advanced techniques in histopathology and morphology, immunochemistry, flow cytometry, cytogenetics, pharmacogenomics, analytical chemistry and molecular biology to standardize diagnoses of hematopoietic and lymphoid neoplasms.  Together, JCML and its tissue bank represent an unprecedented resource for studying the pathogenesis and etiology of different blood diseases and clinical studies to predict individual response and follow up to treatment.

Teaching:
Professional Program: Immunology.
Graduate Program: Pathology, Toxicology.

Representative Publications:
Ryder, J., Wang, X., Bao, L., Gross, S.A., Hua, F. and Irons, R.D. (2006) “Aggressive NK Cell Leukemia: Report of a Chinese Series and Review of the Literature.”  International Journal of Hematology, In Press.
Bao, L., Wang, X., Ryder, J., Ji, M., Chen, Y., Chen, H., Sun, H., Yang, Y., Du, X., Kerzic, P., Gross, SA., Yao, L., Lv, L., Fu, H., Lin, G. and Irons, RD. (2006) “Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations.” European Journal of Haematology.  77: 35-45.
Irons, R.D., Wang, X.-Q., Gross, S.A., Bao, L., Ryder, J., Chen, Y., Chen, H., Sun, H., Zhou, J., Ji, M., Du, X.,. Fu, H. and Lin, G. (2006) “Prevalence of MDS subtypes in Shanghai, China: A comparison of the World Health Organization and French American British Classifications.” Leukemia Research, 30: 769-775.
Gross, SA, Zheng JH, Le, AT, Kerzic, PJ and Irons, RD. (2006) “ PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokine-dependent clonogenic response in human CD34+ hematopoietic progenitor cells.”  Cell Biology and Toxicology.  In Press.
Hu, X, Wang, X, Bao, L, Shui, R, Zhu, X, Irons R.D., Fu, H, Chen, Y, Chen, H，Guo, H, Zhao, X, Yang, X and Li, J.  (2006)  “Cytogenetic and interphase FISH studies in the diagnosis of malignant lymphomas.” Chinese Journal of Oncology, In Press.
Irons, R.D., Lv, L., Gross, S.A., Ye, X., Bao, L., Wang, X.-Q., Ryder, J., Armstrong, T.W., Zhou, Y., Miao, L., Le, A.T., Kerzic, P.J., Ni, W. and Fu, H. (2005) “Chronic exposure to benzene results in a unique form of dysplasia.” Leukemia Research, 29(12): 1371-1380.

Curriculum Vitae
Recent Publications

Last updated: 6/25/07