Alvin M. Malkinson, Ph.D.
Professor of Biochemical Pharmacology,
Department of Pharmaceutical Sciences
Mailing address:
4200 E. 9th Ave, C238
Denver, CO 80262
Telephone:
Voice: 303-315-4579
Lab: 303-315-6769
Fax: 303-315-0274
E-Mail: Al.Malkinson@uchsc.edu
Affiliations:
Member, University of Colorado Cancer Center
Member, Graduate Program in Pharmacology
Training and Education:
B.A., University of Buffalo (Psychology)
Ph.D., Johns Hopkins University (Genetics/Biochemistry)
Research Interests:
My lab studies the role of chronic inflammation in the development of lung tumors in a mouse model of human pulmonary adenocarcinoma, the most common form of human lung cancer. We are studying whether inflammation helps determine the distinctly different fates of early lesions in two chemical carcinogenesis models; one in which all microscopic lesions progress to become large benign tumors and another in which most microscopic lesions spontaneously regress and only a few continue to grow. We also study the role of inflammatory cells in the fates of tumor cells at the interface between the tumor and normal lung tissue; what determines whether or not cells will detach from the primary tumor to invade the adjacent normal tissue or remain confined in situ. We have found gender differences in the fates of tumors, such as their growth rates and responses to endogenous regulators of inflammation as well as molecularly targeted drugs, and in the nature of the mutation that drives neoplastic growth, and are investigating the biochemical bases of these differences. .
Teaching:
Professional Program: Cellular Pathology
Graduate Program: Cancer Biology, Signal Transduction
Representative publications:
O’Donnell, E.P., Zerbe, L., Dwyer-Nield, L.D., Kisley, L.R., and Malkinson, A.M. Quantitative analysis of early chemically-induced pulmonary lesions in mice of varying susceptibilities to lung tumorigenesis. Cancer Lett. 2006, in press.
Meyer, A.M., Dwyer-Nield, L.D., Hurteau, G., Keith, R.L, Ouyang, Y., Freed, B.M., Kisley, L.R., Geraci, M.W., Bonventre, J.V., Nemenoff, R.A., and Malkinson, A.M., Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice. Am. J. Physiol. Lung Cell Mol. Physiol. 290:L1260-L1266, 2006.
Bauer, A.., Dixon, D., DeGraff, L.M., Cho, H-Y., Walker, C.R., Malkinson, A.M., and Kleeberger, S.R. Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J. Natl. Cancer Inst. 97:1778-1781, 2005.
Dwyer-Nield, L.D., Srebernak, M.C., Barrett, B.S., Ahn, J., Cosper, P., Meyer, A.M., Kisley, L.R., Bauer, A.K., Thompson, D.C., and Malkinson, A.M. Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines. Carcinogenesis 26: 1196-1206, 2005.
Malkinson, A.M. role of inflammation in mouse lung tumorigenesis: a review. Exp. Lung Res. 31; 57-82, 2005.
Last updated: 6/25/07