• Agarwal, Rajesh, Ph.D.
• Anchordoquy, Thomas J., Ph.D.
• Anderson, Peter, Pharm.D.
• Aquilante, Christina, Pharm.D.
• Bain, David L., Ph.D.
• Carpenter, John, Ph.D.
• Franklin, Christopher, Ph.D.
• Hail, Jr., Numsen, Ph.D.
• Irons, Richard D., Ph.D.
• Jones Braun, LaToya, Ph.D.
• Ju, Cynthia, Ph.D.
• Kiser, Jennifer, Pharm.D.
• Kompella Uday B., PhD
• Malkinson, Alvin M., Ph.D.
• Mallela, Krishna M. G., Ph.D.
• Maluf, N. Karl, Ph.D.
• Patel, Manisha, Ph.D.
• Petersen, Dennis R., Ph.D.
• Radcliffe, Richard, Ph.D.
• Ross, David, Ph.D.
• Ruth, James. A., Ph.D.
• Scheinman, Robert I., Ph.D.
• Thompson, John A., Ph.D.
• Vasiliou, Vasilis, Ph.D.

Dennis R. Petersen, Ph.D.

Professor of Pharmacogenetics and Pharmacology, Department of Pharmaceutical Sciences

Mailing address:
4200 E. 9th Ave, C238
Denver, CO 80262

Telephone:
Voice:     303-315-6159
Lab:        303-315-6160
Fax:        303-315-0274
E-Mail:  Dennis.Petersen@uchsc.edu

Affiliations:
Member, Graduate Program in Toxicology
Member, University of Colorado Cancer Center
Member, Graduate Program in Pharmacology

Training and Education:
B.S., Sul Ross State University (Animal Science)
Ph.D., University of Wyoming (Biochemical Genetics)

Research Interests:
The primary focus of research in Dr. Petersen’s laboratory involves understanding the molecular mechanisms of oxidative stress as it relates to initiation and progression of liver injury.  The biotransformation of ethanol, as well as liver disorders associated with the accumulation of lipid, result in oxidative stress leading to the peroxidation of membrane lipids.  Products of this lipid peroxidative process include chemically reactive aldehydes that that have the potential to modify proteins involved in critical metabolic pathways or signaling cascades.  A central goal of our studies is to identify the cellular proteins which are targets for by these biogenic aldehydes in order to understand how and why they are selectively modified and also determine the cellular consequences of the modification.  Currently, his laboratory is employing immunologic procedures and mass spectrometry to isolate and identify the aldehyde-modified proteins from cellular or animal models subjected to various forms of oxidative stress.          

Teaching:
Professional Program: Pharmacology, Physiology, Pathophysiology
Graduate Program: Toxicology

Representative Publications:
Petersen, D.R. and Doorn, J.A. Reactions of 4-hydroxynonenal with proteins and cellular targets. Free Radicals in Biol. Med. 37:937-945, 2004.
Burcham, P.C., Fontaine, F.R., Kaminskas, L.M., Petersen, D.R. and Pyke, S.M. Protein adduct-trapping by hydrazinophthalazine drugs: Mechanisms of cytoprotection against acrolein-mediated toxicity.  Molecular Pharmacology. 65:655-664, 2004.
Reichard, J.F. and Petersen, D.R. Differential Regulation of the Nrf2- and AP-1-Responsive Elements by 4-Hydroxy-2-nonenal,t-Butylhydroquinone and Phorbol 12-myristate 13-acetate in Cultured Hepatic Stellate Cells. Biochemical and Biophysical Research Communications 322:842-853, 2004.
Doorn, J.A. , Maser, E. Blum, A.,  Claffey, D. C. and Petersen, D.R. Human carbonyl reductase catalyzes reduction of 4-oxonon-2-enal. Biochemistry, 43:13106-13114,2004.
Carbone, D.L. Doorn, J.A. and Petersen, D.R. 4-Hydroxynonenal regulates 26S proteosomal degradation of alcohol dehydrogenase. Free Radicals in Biol. Med. 37:1430-1439, 2004.

Recent Publications

Last updated: 6/25/07